Risk stratification in long QT syndrome: Are we finally getting closer to a mutation-specific assessment of an individual patient's arrhythmogenic risk?

Heart Rhythm

Volumn 10, Issue 5, 2013, Pages 726-727

  Odening, Katja E ^a   Brunner, Michael ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE2;

AGE; CARDIOVASCULAR RISK; CLINICAL PROTOCOL; ELECTROCARDIOGRAPHY; ENVIRONMENTAL FACTOR; GENE MUTATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEART ARREST; HEART RATE; HUMAN; LONG QT SYNDROME; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84876525563     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2013.02.008     Document Type: Editorial

References (25)

1. D.M. Roden Clinical practice. Long-QT syndrome N Engl J Med 358 2003 169 176
2. J. Benhorin, A.J. Moss, and M. Bak Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations Ann Noninvasive Electrocardiol 7 2002 40 46
3. A. Mathias, A.J. Moss, and C.M. Lopes Prognostic implications of mutation specific QTc standard deviation in congenital long QT syndrome Heart Rhythm 10 2013 720 725
4. S.G. Priori, P.J. Schwartz, and C. Napolitano Risk stratification in the long-QT syndrome N Engl J Med 348 2003 1866 1874
5. A.J. Sauer, A.J. Moss, and S. McNitt Long QT syndrome in adults J Am Coll Cardiol 49 2007 329 337
6. E.S. Kaufman, S. McNitt, and A.J. Moss Risk of death in the long QT syndrome when a sibling has died Heart Rhythm 5 2008 831 836
7. G. Moennig, E. Schulze-Bahr, and H. Wedekind Clinical value of electrocardiographic parameters in genotyped individuals with familial long QT syndrome Pacing Clin Electrophysiol 24 2001 406 415
8. S.G. Priori, C. Napolitano, L. Diehl, and P.J. Schwartz Dispersion of the QT interval: a marker of therapeutic efficacy in the idiopathic long QT syndrome Circulation 89 1994 1681 1689
9. I. Goldenberg, J. Mathew, and A.J. Moss Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification J Am Coll Cardiol 48 2006 1047 1052
10. S.P. Etheridge, S.J. Compton, M. Tristani-Firouzi, and J.W. Mason A new oral therapy for long QT syndrome: long-term oral potassium improves repolarization in patients with HERG mutations J Am Coll Cardiol 42 2003 1777 1782
11. R. Seth, A.J. Moss, and S. McNitt Long QT syndrome and pregnancy J Am Coll Cardiol 49 2007 1092 1098
12. A. Khositseth, D.J. Tester, M.L. Will, C.M. Bell, and M.J. Ackerman Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome Heart Rhythm 1 2004 60 64
13. K.E. Odening, B.R. Choi, and G.X. Liu Estradiol promotes sudden cardiac death in transgenic long-QT type 2 rabbits while progesterone is protective Heart Rhythm 9 2012 823 832
14. W. Shimizu, Y. Tanabe, and T. Aiba Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome J Am Coll Cardiol 39 2002 1984 1991
15. S. Ohno, D.P. Zankov, and H. Yoshida N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome Heart Rhythm 4 2007 332 340
16. A.M. Lahtinen, A. Marjamaa, H. Swan, and K. Kontula KCNE1 D85N polymorphism - a sex-specific modifier in type 1 long QT syndrome? BMC Med Genet 12 2011 11
17. L. Crotti, A.L. Lundquist, and R. Insolia KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome Circulation 112 2005 1251 1258
18. A.S. Amin, J.R. Giudicessi, and A.J. Tijsen Variants in the 3′ untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner Eur Heart J 33 2012 714 723
19. J.B. Saenen, A.D. Paulussen, and R.J. Jongbloed A single hERG mutation underlying a spectrum of acquired and congenital long QT syndrome phenotypes J Mol Cell Cardiol 43 2007 63 72
20. D. Migdalovitch, A.J. Moss, and C.M. Lopes Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome Heart Rhythm 8 2011 1537 1543
21. W. Shimizu, A.J. Moss, and A.A. Wilde Genotype-phenotype aspects of type 2 long QT syndrome J Am Coll Cardiol 54 2009 2052 2062
22. C. Jons, J. O-Uchi, and A.J. Moss Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients Sci Transl Med 3 2011 76ra28
23. A.J. Moss, W. Shimizu, and A.A. Wilde Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene Circulation 115 2007 2481 2489
24. R. Hoefen, M. Reumann, and I. Goldenberg In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models J Am Coll Cardiol 60 2012 2182 2191
25. A. Barsheshet, I. Goldenberg, and J. O-Uchi Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome Circulation 125 2012 1988 1996