Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome

Heart Rhythm

Volumn 8, Issue 10, 2011, Pages 1537-1543

  Migdalovich, Dimitry ^a   Moss, Arthur J ^a   Lopes, Coeli M ^b   Costa, Jason ^a   Ouellet, Gregory ^a   Barsheshet, Alon ^a   McNitt, Scott ^a   Polonsky, Slava ^a   Robinson, Jennifer L ^a   Zareba, Wojciech ^a   Ackerman, Michael J ^c   Benhorin, Jesaia ^d   Kaufman, Elizabeth S ^e   Platonov, Pyotr G ^f   Shimizu, Wataru ^g   Towbin, Jeffrey A ^h   Vincent, G Michael ⁱ   Wilde, Arthur A M ^j   Goldenberg, Ilan ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c MAYO CLINIC   (United States)

^d TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f LUND UNIVERSITY   (Sweden)

^g NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^h UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

ⁱ LDS HOSPITAL   (United States)

^j ACADEMIC MEDICAL CENTER   (Netherlands)

more..

Author keywords

Gender; Long QT syndrome; Pore loop mutations; Sudden cardiac death

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ABORTED CARDIAC ARREST; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARDIAC PATIENT; CARDIOVASCULAR RISK; CONTROLLED STUDY; DEFIBRILLATOR; DEVICE THERAPY; FAMILY HISTORY; FEMALE; FOLLOW UP; GENE MUTATION; GENOTYPE; HAZARD RATIO; HEART ARREST; HIGH RISK PATIENT; HUMAN; LIFE EVENT; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PACEMAKER; PRIORITY JOURNAL; PROBABILITY; REVIEW; RISK ASSESSMENT; SUDDEN DEATH;

EID: 80053051796     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.03.049     Document Type: Article

References (17)

1. A.J. Moss, and R.S. Kass Long QT syndrome: from channels to cardiac arrhythmias J Clin Invest 115 2005 2018 2024 (Pubitemid 41134137)
2. I. Goldenberg, W. Zareba, and A.J. Moss Long QT syndrome Curr Probl Cardiol 33 2008 629 694
3. M.C. Sanguinetti, and M. Tristan-Firouzi hERG potassium channels and cardiac arrhythmia Nature 440 2006 463 469
4. M.C. Sanguinetti HERG1 channelopathies Eur J Physiol 460 2010 265 276
5. A.J. Moss, W. Zareba, and E.S. Kaufman Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel Circulation 105 2002 794 799 (Pubitemid 34174917)
6. W. Shimizu, A.J. Moss, and A.A.M. Wilde Genotype-phenotype aspects of type 2 long QT syndrome J Am Coll Cardiol 54 2009 2052 2062
7. W. Zareba, A.J. Moss, and E.H. Locati Modulating effects of age and gender on the clinical course of cong QT syndrome by genotype J Am Coll Cardiol 42 2003 103 109 (Pubitemid 36760769)
8. H.C. Bazett An analysis of the time relations of electrocardiograms Heart 7 1920 353 367
9. I. Splawski, J. Shen, and K.W. Timothy Spectrum of mutations in long-QT syndrome genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2 Circulation 102 2000 1178 1185
10. C.T. January, Q. Gong, and Z. Zhou Long-QT syndrome: cellular basis and arrhythmia mechanism in LQT2 J Cardiovasc Electrophysiol 11 2000 1413 1418 (Pubitemid 32016868)
11. T.M. Therneau, and P.M. Grambsch Modeling survival data: extending the Cox model 2000 Springer-Verlag New York, NY
12. H. Bidoggia, J.P. Maciel, and N. Capalozza Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone Am Heart J 140 2000 678 683
13. J.M. Ridley, Y.M. Shuba, A.F. James, and J.C. Hancox Modulation by testosterone of an endogenous hERG potassium channel current J Physiol Pharmacol 59 2008 395 407
14. M. Hara, P. Danilo Jr, and M.R. Rosen Effects of gonadal steroids on ventricular repolarization and on the response to E4031 J Pharmacol Exp Ther 285 1998 1068 1072 (Pubitemid 28277905)
15. M. Song, G. Helguera, and M. Eghbali Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones J Biol Chem 276 2001 31883 31890
16. S.G. Priori, P.J. Schwartz, and C. Napolitano Risk stratification in the long-QT syndrome N Engl J Med 348 2003 1866 1874 (Pubitemid 36532312)
17. S.G. Priori, C. Napolitano, and P.J. Schwartz Association of long QT syndrome loci and cardiac events among patients treated with β-blockers JAMA 292 2004 1341 1344 (Pubitemid 39223225)