Prognostic value of p53 and Ki67 expression in fiberoptic bronchial biopsies of patients with non small cell lung cancer

Multidisciplinary Respiratory Medicine

Volumn 7, Issue 4, 2012, Pages

  Ciancio, Nicola ^a   Galasso, Maria Grazia ^b   Campisi, Raffaele ^a   Bivona, Laura ^a   Migliore, Marcello ^c   Di Maria, Giuseppe U ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b GARIBALDI HOSPITAL   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; PROTEIN P53;

ADULT; AGED; ARTICLE; BRONCHUS BIOPSY; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; FIBEROPTIC BRONCHIAL BIOPSY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; SURVIVAL RATE; SURVIVAL TIME;

EID: 84876521525     PISSN: 1828695X     EISSN: 20496958     Source Type: Journal    
DOI: 10.1186/2049-6958-7-29     Document Type: Article

References (34)

1. Hollstein M, Sidransky D, Vogelstein B, Harris C: p53 mutations in human cancer. Science 1991, 253:49-53.
2. Mercer WE, Avignolo C, Baserga R: Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Mol Cell Biol 1984, 4:276-281.
3. Hall PA, Lane DP: p53 in tumor pathology, can we trust immunohistochemistry? J Pathol 1994, 172:1-4. (Pubitemid 24074994)
4. Iggo R, Gatter K, Bartek J, Lane D, Harris AL: Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 1990, 335:675-679. (Pubitemid 20089305)
5. Steels E, Paesmans M, Berghmans T, Branle F, Lemaitre F, Mascaux C, Meert AP, Vallot F, Lafitte JJ, Sculier JP: Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis. EurRespir J 2001, 18:705-719. (Pubitemid 33040631)
6. Tammemagi MC, McLaughlin JR, Bull SB: Meta-analyses of p53 tumor suppressor gene alterations and clinicopathological features in resected lung cancers. Cancer Epidemiol Biomarkers Prev 1999, 8:625-634. (Pubitemid 29337324)
7. Mitsudomi T, Lam S, Shirakusa T, Gazdar AF: Detection and sequencing of p53 gene mutations in bronchial biopsy samples in patients with lung cancer. Chest 1993, 104:362-365. (Pubitemid 23229498)
8. Orfanidou D, Kalomenidis J, Rasidakis A, Papamichalis G, Toumbin M, Labaditis J, Sacharidou A, Papastamatiou H, Jordanoglou J: Immunohistochemical detection of p53 protein in neoplastic, preneoplastic and normal bronchial mucosa specimens obtained during diagnostic bronchoscopy. Oncol Rep 1998, 5:763-769. (Pubitemid 28189342)
9. Lang SM, Stratakis DF, Freudling A, Ebelt K, Oduncu F, Hautmann H, Huber RM: Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer. Eur J Med Res 2000, 5:341-346.
10. Kawasaki M, Nakanishi Y, Kuwano K, Yatsunami J, Takayama K, Hara N: The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non small cell lung cancer. Clin Cancer Res 1997, 3:1195-2000.
11. Hall PA, Richards MA, Gregory WM, D'ardenne AJ, Lister TA, Stansfeld AG: The prognostic value of KI67 immunostaining in non-Hodgkin's lymphoma. J Pathol 1988, 154:223-225.
12. Walker RA, Camplejohn RS: Comparison of monoclonal antibody Ki67 reactivity with grade and DNA flow cytometry of breast carcinomas. Br J Cancer 1988, 57:281-283. (Pubitemid 18096335)
13. Soomro IN, Whimster WF: Growth fraction in lung tumours determined by Ki67 immunostaining and comparison with AgNOR scores. J Pathol 1990, 162:217-222.
14. Scagliotti GV, Micela M, Gubetta L, Leonardo E, Cappia S, Borasio P, Pozzi E: Prognostic significance of Ki67 labelling in resected non small cell lung cancer. Eur J Cancer 1993, 29A:363-365. (Pubitemid 23025742)
15. Hommura F, Dosaka-Akita H, Mishina T, Nishi M, Kojima T, Hiroumi H, Ogura S, Shimizu M, Katoh H, Kawakami Y: Prognostic significance of p27KIP1 protein and ki-67 growth fraction in non-small cell lung cancers. Clin Cancer Res 2000, 6:4073-4081.
16. Nguyen VN, Mirejovski T, Melinova L, Mandys V: Expression of cyclin D1, Ki67 and PCNA in non-small cell lung cancer: prognostic significance and comparison with p53 and bcl-2. Acta Histochem 2000, 102:232-238.
17. Maddau C, Confortini M, Bisanzi S, Janni A, Montinaro F, Paci E, Pontenani G, Rulli P, Salani A, Zappa M, Benvenuti A, Carozzi FM: Prognostic significance of p53 and Ki-67 antigen expression in surgically treated non-small cell lung cancer: immunocytochemical detection with imprint cytology. Am J Clin Pathol 2006, 125:425-431. (Pubitemid 43327713)
18. Ishida H, Irie K, Itoh T, Furukawa T, Tokunaga O: The prognostic significance of p53 and bcl-2 expression in lung adenocarcinoma and its correlation with Ki-67 growth fraction. Cancer 1997, 80:1034-1045. (Pubitemid 27427602)
19. Martin B, Paesmans M, Mascaux C, Berghmans T, Lothaire P, Meert A-P, Lafitte J-J, Sculier J-P: Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis. Br J Cancer 2004, 91:2018-2025. (Pubitemid 40128768)
20. Sobin L, Gospodarowicz M, Wittekind C, International Union Against Cancer: TNM: Classification of Malignat Tumours. 7th edition. New York: Wiley-Blackwel; 2009:138-146.
21. Travis WD, Brambilla E: International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. J Thor Oncol 2011, 2:244-285.
22. Fouquet C, Antoine M, Tisserand P, Favis R, Wislez M, Commo F, Rabbe N, Carette F, Milleron B, Barany F, Cadranel J, Zalcman G, Soussi T: Rapid and Sensitive p53 Alteration Analysis in Biopsies from Lung Cancer Patients Using a Functional Assay and A Universal Oligonucleotide Array: A Prospective Study. Clin Cancer Res 2004, 10:3479-3489. (Pubitemid 38685456)
23. Murakami I, Fujiwara Y, Yamaoka N, Hiyama K, Hishioka S, Yamakido M: Detection of p53 gene mutations in cytopathology and biopsy specimens from patients with lung cancer. Am J RespirCrit Care Med 1996, 154:1117-1123.
24. Mitsudomi T, Oyama T, Kusano T, Osaki T, Nakanishi R, Shirakusa T: Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer. J Natl Cancer Inst 1993, 85:2018-2023. (Pubitemid 24000986)
25. Quinland DC, Davidson AG, Summers CL, Warden HE, Doshi HM: Accumulation of p53 proteins correlates with a poor prognosis in human lung cancer. Cancer Res 1992, 52:4828-4831.
26. Morkve O, Halvorsen OJ, Skjaerven R, Stangeland L, Gulsvik A, Laerum OD: Prognostic significance of p53 protein expression and DNA ploidy in surgical treated non-small cell lung cancer. Anticancer Res 1993, 13:571-578. (Pubitemid 23216948)
27. Ohsaki Y, Toyoshima E, Fujiuchi S, Matsui H, Hirata S, Miyoakawa N, Kubo Y, Kikuchi K: bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time. Clin Cancer Res 1996, 2:915-920. (Pubitemid 26169993)
28. Tanaka F, Yanagihara K, Otake Y, Yamada T, Shoji T, Miyahara R, Inui K, Wada H: Prognostic factors in patients with resected pathologic (p-) T1-2N1M0 non-small cell lung cancer (NSCLC). Eur J Cardiothorac Surg 2001, 19:555-561. (Pubitemid 32416603)
29. Top B, Mooi WJ, Klaver SG, Boerrigter L, Wisman P, Elbers HR, Visser S, Rodenhuis S: Comparative analysis of p53 gene mutations and protein accumulation in human non small cell lung cancer. Int J Cancer 1995, 64:83-91.
30. Passlick B, Izbicki JR, Haussinger K, Thetter O, Pantel K: Immunohistochemical detection of P53 protein is not associated with a poor prognosis in non-small-cell lung cancer. J Thorac Cardiovasc Surg 1995, 109:1205-1211.
31. Nishio M, Koshikawa T, Kuroishi T, Suyama M, Uchida K, Takagi Y, Washimi O, Sugiura T, Ariyoshi Y, Takahashi T, Ueda R: Prognostic significance of abnormal p53 accumulation in primary, resected non-small cell lung cancer. J Clin Oncol 1996, 14:497-502. (Pubitemid 26051013)
32. Tsao M-S, Aviel-Ronen S, Ding K, Lau D, Liu N, Sakurada A, Whitehead M, Zhu C-O, Livingston R, Johnson DH, Rigas J, Seymour L, Winton T, Shepherd FA: Prognostic and Predictive Importance of p53 and RAS for Adjuvant Chemotherapy in Non-Small-Cell Lung Cancer. J Clin Oncol 2007, 25:5240-5247. (Pubitemid 350232256)
33. Viberti L, Papotti M, Abbona GC, Celano A, Filosso PL, Bussolati G: Value of Ki-67 immunostaining in preoperative biopsies of carcinomas of the lung. Hum Pathol 1997, 28:189-192. (Pubitemid 27069185)
34. Mehdi SA, Etzell JE, Newman NB, Weidner N, Kohman LJ, Graziano SL: Prognostic significance of Ki-67 immunostaining and symptoms in resected stageI and II non-small cell lung cancer. Lung Cancer 1998, 20:99-108. (Pubitemid 28345191)