Not just specific diseases: Systematic review of the association of geriatric syndromes with hospitalization or nursing home admission

Archives of Gerontology and Geriatrics

Volumn 57, Issue 1, 2013, Pages 16-26

  Wang, Shi Yi ^a   Shamliyan, Tatyana A ^a   Talley, Kristine M C ^b   Ramakrishnan, Rema ^a   Kane, Robert L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Disability; Frailty; Geriatric syndrome; Hospitalization; Long term care; Systematic review

Indexed keywords

AGED; CHRONIC INFLAMMATION; COCHRANE LIBRARY; COGNITIVE DEFECT; COMMUNITY LIVING; DISABILITY; GERIATRIC DISORDER; GERIATRIC SYNDROME; HOSPITALIZATION; HUMAN; INSTITUTIONALIZATION; MALNUTRITION; MEDLINE; MORBIDITY; MUSCLE ATROPHY; NURSING HOME; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW;

AGED; CHRONIC DISEASE; COGNITION DISORDERS; DISABLED PERSONS; FRAIL ELDERLY; GERIATRICS; HOSPITALIZATION; HUMANS; MOBILITY LIMITATION; NURSING HOMES; PATIENT ADMISSION; SYNDROME; URINARY INCONTINENCE;

EID: 84876502692     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2013.03.007     Document Type: Review

References (94)

1. Aliyu M.H., Adediran A.S., Obisesan T.O. Predictors of hospital admissions in the elderly: Analysis of data from the Longitudinal Study on Aging. Journal of the National Medical Association 2003, 95(12):1158-1167.
2. Anderson R.T., James M.K., Miller M.E., Worley A.S., Longino C.F. The timing of change: Patterns in transitions in functional status among elderly persons. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 1998, 53(1):S17-S27.
3. Avila-Funes J.A., Amieva H., Barberger-Gateau P., Le Goff M., Raoux N., Ritchie K., et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: The three-city study. Journal of the American Geriatrics Society 2009, 57(3):453-461.
4. Avila-Funes J.A., Helmer C., Amieva H., Barberger-Gateau P., Le Goff M., Ritchie K., et al. Frailty among community-dwelling elderly people in France: The three-city study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2008, 63(10):1089-1096.
5. Banaszak-Holl J., Fendrick A.M., Foster N.L., Herzog A.R., Kabeto M.U., Kent D.M., et al. Predicting nursing home admission: Estimates from a 7-year follow-up of a nationally representative sample of older Americans. Alzheimer Disease and Associated Disorders 2004, 18(2):83-89.
6. Bandeen-Roche K., Xue Q.L., Ferrucci L., Walston J., Guralnik J.M., Chaves P., et al. Phenotype of frailty: Characterization in the women's health and aging studies. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2006, 61(3):262-266.
7. Bauer J.M., Sieber C.C. Sarcopenia and frailty: A clinician's controversial point of view. Experimental Gerontology 2008, 43(7):674-678.
8. Beck A.M., Holst M., Rasmussen H.H. Efficacy of the Mini Nutritional Assessment to predict the risk of developing malnutrition or adverse health outcomes for old people. e-SPEN 2008, 3. e102e7.
9. Beck A.M., Ovesen L., Osler M. The 'Mini Nutritional Assessment' (MNA) and the 'Determine Your Nutritional Health' Checklist (NSI Checklist) as predictors of morbidity and mortality in an elderly Danish population. British Journal of Nutrition 1999, 81(1):31-36.
10. Belgrave L.L., Bradsher J.E. Health as a factor in institutionalization. Research on Aging 1994, 16(2):115-141.
11. Besdine R., Boult C., Brangman S., Coleman E.A., Fried L.P., Gerety M., et al. Caring for older Americans: The future of geriatric medicine. Journal of the American Geriatrics Society 2005, 53(6 Suppl.):S245-S256.
12. Bierman, A., Spector, W., Atkins, D., Basu, J., Clancy, C., Gross, M. et al. (2001). Improving the Health Care of Older Americans. A report of the AHRQ Task Force on Aging. Agency for Healthcare Research and Quality, Rockville, MD. AHRQ Publication No. 01-0030 Available at:. http://www.ahrq.gov/research/olderam/oldam1.htm.
13. Boult C., Dowd B., McCaffrey D., Boult L., Hernandez R., Krulewitch H. Screening elders for risk of hospital admission. Journal of the American Geriatrics Society 1993, 41(8):811-817.
14. Branch L.G., Katz S., Kniepmann K., Papsidero J.A. A prospective study of functional status among community elders. American Journal of Public Health 1984, 74(3):266-268.
15. Cao J.J., Arnold A.M., Manolio T.A., Polak J.F., Psaty B.M., Hirsch C.H., et al. Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: The Cardiovascular Health Study. Circulation 2007, 116(1):32-38.
16. Cawthon P.M., Fox K.M., Gandra S.R., Delmonico M.J., Chiou C.F., Anthony M.S., et al. Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?. Journal of the American Geriatrics Society 2009, 57(8):1411-1419.
17. Cereda E., Pedrolli C., Zagami A., Vanotti A., Piffer S., Opizzi A., et al. Nutritional screening and mortality in newly institutionalised elderly: A comparison between the geriatric nutritional risk index and the mini nutritional assessment. Clinical Nutrition 2011, 30(6):793-798.
18. Chodosh J., Seeman T.E., Keeler E., Sewall A., Hirsch S.H., Guralnik J.M., Reuben D.B. Cognitive decline in high-functioning older persons is associated with an increased risk of hospitalization. Journal of the American Geriatrics Society 2004, 52(9):1456-1462.
19. Coward R.T., Netzer J.K., Mullens R.A. Residential differences in the incidence of nursing home admissions across a six-year period. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 1996, 51(5):S258-S267.
20. Current Population Reports (1983). Series P-25, Number 929, Estimates of the Population of the U.S. by Age, Sex, and Race, U.S. Department of Commerce, Available at:. http://www2.census.gov/prod2/decennial/documents/1980/1980censusofpopu8011u_bw.pdf.
21. Dallman P.R., Yip R., Johnson C. Prevalence and causes of anemia in the United States, 1976 to 1980. American Journal of Clinical Nutrition 1984, 39(3):437-445.
22. Dorr D.A., Jones S.S., Burns L., Donnelly S.M., Brunker C.P., Wilcox A., Clayton P.D. Use of health-related, quality-of-life metrics to predict mortality and hospitalizations in community-dwelling seniors. Journal of the American Geriatrics Society 2006, 54(4):667-673.
23. Eaker E.D., Vierkant R.A., Mickel S.F. Predictors of nursing home admission and/or death in incident Alzheimer's disease and other dementia cases compared to controls: A population-based study. Journal of Clinical Epidemiology 2002, 55(5):462-468.
24. Fairhall N., Langron C., Sherrington C., Lord S.R., Kurrle S.E., Lockwood K., et al. Treating frailty-a practical guide. BMC Med 2011, 9:83. doi: 10.1186/1741-7015-9-83.
25. Falconer J., Naughton B.J., Hughes S.L., Chang R.W., Singer R.H., Sinacore J.M. Self-reported functional status predicts change in level of care in independent living residents of a continuing care retirement community. Journal of the American Geriatrics Society 1992, 40(3):255-258.
26. Ferrucci L., Guralnik J.M., Pahor M., Corti M.C., Havlik R.J. Hospital diagnoses, medicare charges, and nursing home admissions in the year when older persons become severely disabled. JAMA 1997, 277(9):728-734.
27. Ferrucci L., Guralnik J.M., Studenski S., Fried L.P., Cutler G.B., Walston J.D. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: A consensus report. Journal of the American Geriatrics Society 2004, 52(4):625-634.
28. Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., et al. Frailty in older adults: Evidence for a phenotype. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2001, 56(3):M146-M156.
29. Gardener E.A., Huppert F.A., Guralnik J.M., Melzer D. Middle-aged and mobility-limited: Prevalence of disability and symptom attributions in a national survey. Journal of General Internal Medicine 2006, 21(10):1091-1096.
30. Gaugler J.E., Duval S., Anderson K.A., Kane R.L. Predicting nursing home admission in the U.S: A meta-analysis. BMC Geriatr 2007, 7:13. doi: 10.1186/1471-2318-7-13.
31. Gill T.M., Allore H.G., Holford T.R., Guo Z. Hospitalization, restricted activity, and the development of disability among older persons. JAMA 2004, 292(17):2115-2124.
32. Goodlin S., Boult C., Bubolz T., Chiang L. Who will need long-term care? Creation and validation of an instrument that identifies older people at risk. Dis Manag 2004, 7(4):267-274.
33. Graham J.E., Rockwood K., Beattie B.L., Eastwood R., Gauthier S., Tuokko H., McDowell I. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 1997, 349(9068):1793-1796.
34. Gutman G.M., Stark A., Donald A., Beattie B.L. Contribution of self-reported health ratings to predicting frailty, institutionalization, and death over a 5-year period. International Psychogeriatrics 2001, 13(Supp1):223-231.
35. Guyatt G.H., Oxman A.D., Kunz R., Brozek J., Alonso-Coello P., Rind D., et al. GRADE guidelines 6. Rating the quality of evidence-imprecision. Journal of Clinical Epidemiology 2011, 64(12):1283-1293.
36. Harris R.P., Helfand M., Woolf S.H., Lohr K.N., Mulrow C.D., Teutsch S.M., Atkins D. Current methods of the US Preventive Services Task Force: A review of the process. American Journal of Preventive Medicine 2001, 20(3 Suppl.):21-35.
37. Harris T., Kovar M.G., Suzman R., Kleinman J.C., Feldman J.J. Longitudinal study of physical ability in the oldest-old. American Journal of Public Health 1989, 79(6):698-702.
38. Hastings S.N., Purser J.L., Johnson K.S., Sloane R.J., Whitson H.E. Frailty predicts some but not all adverse outcomes in older adults discharged from the emergency department. Journal of the American Geriatrics Society 2008, 56(9):1651-1657.
39. Idler E.L., Benyamini Y. Self-rated health and mortality: A review of twenty-seven community studies. Journal of Health and Social Behavior 1997, 38(1):21-37.
40. Inouye S.K., Studenski S., Tinetti M.E., Kuchel G.A. Geriatric syndromes: Clinical, research and policy implications of a core geriatric concept. Journal of the American Geriatrics Society 2007, 55(5):780.
41. Inouye S.K., Zhang Y., Jones R.N., Shi P., Cupples L.A., Calderon H.N., Marcantonio E.R. Risk factors for hospitalization among community-dwelling primary care older patients: Development and validation of a predictive model. Medical Care 2008, 46(7):726-731.
42. Isaacs B. Ageing and the doctor. The impact of ageing 1981, Croom Helm, London. D. Hobman (Ed.).
43. Johnson M.A., Fischer J.G., Park S. Vitamin D deficiency and insufficiency in the Georgia Older Americans Nutrition Program. Journal of Nutrition for the Elderly 2008, 27(1-2):29-46.
44. Jones D., Song X., Mitnitski A., Rockwood K. Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians. Aging Clinical and Experimental Research 2005, 17(6):465-471.
45. Kane R.L., Shamliyan T., Talley K., Pacala J. The association between geriatric syndromes and survival. Journal of the American Geriatrics Society 2012, 60(5):896-904.
46. Kane, R. L., Talley, K. M. C., Shamliyan, T., & Pacala, J. T. (2011). Common syndromes in older adults related to primary and secondary prevention, Rockville. (MD).
47. Kersting R.C. Impact of social support, diversity, and poverty on nursing home utilization in a nationally representative sample of older Americans. Social Work in Health Care 2001, 33(2):67-87.
48. Kersting R.C. Predictors of nursing home admission for older black Americans. Journal of Gerontological Social Work 2001, 35(3):33-50.
49. Kiely D.K., Cupples L.A., Lipsitz L.A. Validation and comparison of two frailty indexes: The MOBILIZE Boston Study. Journal of the American Geriatrics Society 2009, 57(9):1532-1539.
50. Kinney J.M. Nutritional frailty, sarcopenia and falls in the elderly. Current Opinion in Clinical Nutrition and Metabolic Care 2004, 7(1):15-20.
51. Ko F.C. The clinical care of frail, older adults. Clinics in Geriatric Medicine 2011, 27(1):89-100.
52. Kunkel, S. R., Applebaum, R. A. & Mehdizadeh, S. (1991). Estimating the prevalence of long-term disability for an aging population: Technical documentation. U.S. Department of Health and Human Services, Assistant Secretary of Planning and Evaluation, Office of Disability, Aging and Long-Term Care Policy. Available at:. http://aspe.hhs.gov/daltcp/reports/agsocestd.pdf.
53. Laditka J.N. Hazards of hospitalization for ambulatory care sensitive conditions among older women: Evidence of greater risks for African Americans and Hispanics. Medical Care Research and Review 2003, 60(4):468-495. discussion 496-508.
54. Lesourd B., Decarli B., Dirren H. Longitudinal changes in iron and protein status of elderly Europeans. SENECA Investigators. European Journal of Clinical Nutrition 1996, 50(Suppl. 2):S16-S24.
55. Long S.K., Liu K., Black K., O'Keeffe J., Molony S. Getting by in the community: Lessons from frail elders. Journal of Aging and Social Policy 2005, 17(1):19-44.
56. Luppa M., Luck T., Weyerer S., Konig H.H., Brahler E., Riedel-Heller S.G. Prediction of institutionalization in the elderly. A systematic review. Age and Ageing 2010, 39(1):31-38.
57. Marshall J.A., Lopez T.K., Shetterly S.M., Morgenstern N.E., Baer K., Swenson C., et al. Indicators of nutritional risk in a rural elderly Hispanic and non-Hispanic white population: San Luis Valley Health and Aging Study. Journal of the American Dietetic Association 1999, 99(3):315-322.
58. Martin C.T., Kayser-Jones J., Stotts N.A., Porter C., Froelicher E.S. Risk for low weight in community-dwelling, older adults. Clinical Nurse Specialist 2007, 21(4):203-211.
59. Mazzaglia G., Roti L., Corsini G., Colombini A., Maciocco G., Marchionni N., et al. Screening of older community-dwelling people at risk for death and hospitalization: The Assistenza Socio-Sanitaria in Italia project. Journal of the American Geriatrics Society 2007, 55(12):1955-1960.
60. Miller E.A., Weissert W.G. Predicting elderly people's risk for nursing home placement, hospitalization, functional impairment, and mortality: A synthesis. Medical Care Research and Review 2000, 57(3):259-297.
61. Miller M.E., Longino C.F., Anderson R.T., James M.K., Worley A.S. Functional status, assistance, and the risk of a community-based move. Gerontologist 1999, 39(2):187-200.
62. Mor V., Wilcox V., Rakowski W., Hiris J. Functional transitions among the elderly: Patterns, predictors, and related hospital use. American Journal of Public Health 1994, 84(8):1274-1280.
63. Nakasato Y.R., Carnes B.A. Myopathy, polymyalgia rheumatica, and temporal arteritis. Hazzard's Geriatric Medicine and Gerontology 2009, Vol. 6e. http://www.accessmedicine.com/content.aspx?aID=5135557).
64. Nelson K.M., Reiber G., Kohler T., Boyko E.J. Peripheral arterial disease in a multiethnic national sample: The role of conventional risk factors and allostatic load. Ethnicity and Disease 2007, 17(4):669-675.
65. Newman A.B., Yanez D., Harris T., Duxbury A., Enright P.L., Fried L.P. Weight change in old age and its association with mortality. Journal of the American Geriatrics Society 2001, 49(10):1309-1318.
66. Nuotio M., Tammela T.L., Luukkaala T., Jylha M. Predictors of institutionalization in an older population during a 13-year period: The effect of urge incontinence. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2003, 58(8):756-762.
67. Olde Rikkert M.G., Rigaud A.S., van Hoeyweghen R.J., de Graaf J. Geriatric syndromes: Medical misnomer or progress in geriatrics?. Netherlands Journal of Medicine 2003, 61(3):83-87.
68. Onder G., Landi F., Volpato S., Fellin R., Carbonin P., Gambassi G., Bernabei R. Serum cholesterol levels and in-hospital mortality in the elderly. American Journal of Medicine 2003, 115(4):265-271.
69. Owens D.K., Lohr K.N., Atkins D., Treadwell J.R., Reston J.T., Bass E.B., et al. AHRQ series paper 5: Grading the strength of a body of evidence when comparing medical interventions-agency for healthcare research and quality and the effective health-care program. Journal of Clinical Epidemiology 2010, 63(5):513-523.
70. Patel K.V., Semba R.D., Ferrucci L., Newman A.B., Fried L.P., Wallace R.B., et al. Red cell distribution width and mortality in older adults: A meta-analysis. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2010, 65(3):258-265.
71. Rockwood K., Hogan D.B., MacKnight C. Conceptualisation and measurement of frailty in elderly people. Drugs and Aging 2000, 17(4):295-302.
72. Rockwood K., Stolee P., McDowell I. Factors associated with institutionalization of older people in Canada: Testing a multifactorial definition of frailty. Journal of the American Geriatrics Society 1996, 44(5):578-582.
73. Rothman M.D., Leo-Summers L., Gill T.M. Prognostic significance of potential frailty criteria. Journal of the American Geriatrics Society 2008, 56(12). 2211-2116.
74. Sawaya G.F., Guirguis-Blake J., LeFevre M., Harris R., Petitti D. Update on the methods of the U.S. Preventive Services Task Force: Estimating certainty and magnitude of net benefit. Annals of Internal Medicine 2007, 147(12):871-875.
75. Shelton P., Sager M.A., Schraeder C. The community assessment risk screen (CARS): Identifying elderly persons at risk for hospitalization or emergency department visit. American Journal of Managed Care 2000, 6(8):925-933.
76. Speare A., Avery R., Lawton L. Disability, residential mobility, and changes in living arrangements. Journal of Gerontology 1991, 46(3):S133-S142.
77. St John P.D., Montgomery P.R., Kristjansson B., McDowell I. Cognitive scores, even within the normal range, predict death and institutionalization. Age and Ageing 2002, 31(5):373-378.
78. Stearns S.C., Kovar M.G., Hayes K., Koch G.G. Risk indicators for hospitalization during the last year of life. Health Services Research 1996, 31(1):49-69.
79. Steinbach U. Social networks, institutionalization, and mortality among elderly people in the United States. Journal of Gerontology 1992, 47(4):S183-S190.
80. Stookey J.D., Purser J.L., Pieper C.F., Cohen H.J. Plasma hypertonicity: Another marker of frailty?. Journal of the American Geriatrics Society 2004, 52(8):1313-1320.
81. Tinetti M.E., Inouye S.K., Gill T.M., Doucette J.T. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 1995, 273(17):1348-1353.
82. Topinkova E. Aging, disability and frailty. Annals of Nutrition and Metabolism 2008, 52(Suppl. 1):6-11.
83. Vanitallie T.B. Frailty in the elderly: Contributions of sarcopenia and visceral protein depletion. Metabolism: Clinical & Experimental 2003, 52(10 (Suppl. 2)):22-26.
84. Visser M., Deeg D.J., Puts M.T., Seidell J.C., Lips P. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. American Journal of Clinical Nutrition 2006, 84(3):616-622.
85. Visser M., Pahor M., Taaffe D.R., Goodpaster B.H., Simonsick E.M., Newman A.B., et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2002, 57(5):M326-M332.
86. Visvanathan R., Macintosh C., Callary M., Penhall R., Horowitz M., Chapman I. The nutritional status of 250 older Australian recipients of domiciliary care services and its association with outcomes at 12 months. Journal of the American Geriatrics Society 2003, 51(7):1007-1011.
87. Weiner M., Powe N.R., Weller W.E., Shaffer T.J., Anderson G.F. Alzheimer's disease under managed care: Implications from Medicare utilization and expenditure patterns. Journal of the American Geriatrics Society 1998, 46(6):762-770.
88. Wieland D., Lamb V.L., Sutton S.R., Boland R., Clark M., Friedman S., et al. Hospitalization in the Program of All-Inclusive Care for the Elderly (PACE): Rates, concomitants, and predictors. Journal of the American Geriatrics Society 2000, 48(11):1373-1380.
89. Wolinsky F.D., Callahan C.M., Fitzgerald J.F., Johnson R.J. Changes in functional status and the risks of subsequent nursing home placement and death. Journal of Gerontology 1993, 48(3):S94-S101.
90. Wolinsky F.D., Culler S.D., Callahan C.M., Johnson R.J. Hospital resource consumption among older adults: A prospective analysis of episodes, length of stay, and charges over a seven-year period. Journal of Gerontology 1994, 49(5):S240-S252.
91. Wolinsky F.D., Johnson R.J. The use of health services by older adults. Journal of Gerontology 1991, 46(6):S345-S357.
92. Wolinsky F.D., Johnson R.J. Perceived health status and mortality among older men and women. Journal of Gerontology 1992, 47(6):S304-S312.
93. Wolinsky F.D., Stump T.E., Johnson R.J. Hospital utilization profiles among older adults over time: Consistency and volume among survivors and decedents. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 1995, 50(2):S88-S100.
94. Xue Q.L., Fried L.P., Glass T.A., Laffan A., Chaves P.H., Xue Q.-L., et al. Life-space constriction, development of frailty, and the competing risk of mortality: The Women's Health And Aging Study I. American Journal of Epidemiology 2008, 167(2):240-248.