Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress

Hormones and Behavior

Volumn 63, Issue 4, 2013, Pages 615-624

  Lucas Thompson, Rachel G ^a   Holman, E Alison ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

9 11; Economic stress; Gender differences; Impaired functioning; Negative social environment; OXTR; Oxytocin system; Post traumatic stress

Indexed keywords

OXYTOCIN RECEPTOR;

ACUTE STRESS; ADULT; AGED; ALLELE; ARTICLE; CONFLICT; CONTROLLED STUDY; DAILY LIFE ACTIVITY; ECONOMIC ASPECT; ENVIRONMENTAL STRESS; FEMALE; GENDER; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MENTAL STRESS; OXTR GENE; POSTTRAUMATIC STRESS DISORDER; PREDICTION; PRIORITY JOURNAL; SALIVA ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL DISABILITY; SOCIAL ENVIRONMENT; SOCIAL INTERACTION; TERRORISM;

ADULT; ALLELES; ECONOMICS; FEMALE; GENOTYPE; HEALTH STATUS; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL HEALTH; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN; SEX CHARACTERISTICS; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; TERRORISM; WORK;

EID: 84876499132     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2013.02.015     Document Type: Article

References (82)

1. Aiken L.S., West S.G. Multiple Regression: Testing and Interpreting Interactions 1991, Sage Publications, Inc., Thousand Oaks, CA, US.
2. Antonucci T.C. Social supports and social relationships. Handbook of Aging and the Social Sciences 1990, 94-198. Academic Press, San Diego, CA. 3rd ed. R.H. Binstock, E. Shanas (Eds.).
3. Arling G. Strain, social support, and distress in old-age. J. Gerontol. 1987, 42(1):107-113.
4. Association A.P. Diagnostic and Statistical Manual of Mental Disorders 2000, American Psychological Association, Washington, DC, (text rev. ed.). 4th ed.
5. Bakermans-Kranenburg M.J., van IJzendoorn M.H. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc. Cogn. Affect. Neurosci. 2008, 3(2):128-134. 10.1093/Scan/Nsn004.
6. Baumeister R.F., Leary M.R. The need to belong: desire for interpersonal attachments as a fundamental human motivation. Psychol. Bull. 1995, 117(3):497-529.
7. Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol. Bull. 2009, 135(6):885.
8. Blanchard E.B., Jones-Alexander J., Buckley T.C., Forneris C.A. Psychometric properties of the PTSD checklist (PCL). Behav. Res. Ther. 1996, 34(8):669-673.
9. Breslau N., Kessler R.C., Chilcoat H.D., Schultz L.R., Davis G.C., Andreski P. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of trauma. Arch. Gen. Psychiatry 1998, 55:626-632.
10. Broekman B.F.P., Olff M., Boer F. The genetic background to PTSD. Neurosci. Biobehav. Rev. 2007, 31(3):348-362. 10.1016/j.neubiorev.2006.10.001.
11. Cardena E., Koopman C., Classen C., Waelde L.C., Spiegel D. Psychometric properties of the Stanford Acute Stress Reaction Questionnaire (SASRQ): a valid and reliable measure of acute stress. J. Trauma. Stress. 2000, 13(4):719-734. 10.1023/A:1007822603186.
12. Charuvastra A., Cloitre M. Social bonds and posttraumatic stress disorder. Annu. Rev. Psychol. 2008, 59:301-328. 10.1146/annurev.psych.58.110405.085650.
13. Chen F.S., Kumsta R., von Dawans B., Monakhov M., Ebstein R.P., Heinrichs M. Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(50):19937-19942. 10.1073/pnas.1113079108.
14. Cohen S. Psychosocial models of the role of social support in the etiology of physical disease. Heal. Psychol. 1988, 7(3):269-297.
15. Cohn M.A., Mehl M.R., Pennebaker J.W. Linguistic markers of psychological change surrounding September 11, 2001. Psychol. Sci. 2004, 15(10):687-693.
16. Conejero S., Etxebarria I. The impact of the Madrid bombing on personal emotions, emotional atmosphere and emotional climate. J. Soc. Issues 2007, 63(2):273-287.
17. Conger R.D., Conger K.J., Elder G.H., Lorenz F.O., Simons R.L., Whitbeck L.B. Family economic-stress and adjustment of early adolescent girls. Dev. Psychol. 1993, 29(2):206-219.
18. Conger R.D., Ge X., Elder G.H., Lorenz F.O. Economic stress, coercive family process, and developmental problems of adolescents. Child Dev. 1994, 65(2):541-561.
19. Costa B., Pini S., Gabelloni P., Abelli M., Lari L., Cardini A., Martini C. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology 2009, 34(10):1506-1514. 10.1016/j.psyneuen.2009.05.006.
20. Creamer M., Burgess P., McFarlane A.C. Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-being. Psychol. Med. 2001, 31(7):1237-1247.
21. Dooley D., Fielding J., Levi L. Health and unemployment. Annu. Rev. Public Health 1996, 17:449-465.
22. Feldman R., Weller A., Zagoory-Sharon O., Levine A. Evidence for a neuroendocrinological foundation of human affiliation - plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol. Sci. 2007, 18(11):965-970.
23. Fiori K.L., Antonucci T.C., Cortina K.S. Social network typologies and mental health among older adults. J. Gerontol. Psychol. Sci. 2006, 61(1):P25-P32.
24. Fischer-Shofty M., Levkovitz Y., Shamay-Tsoory S.G. Oxytocin facilitates accurate perception of competition in men and kinship in women. Soc. Cogn. Affect. Neurosci 2012, 10.1093/scan/nsr100.
25. Flaherty J., Richman J. Gender differences in the perception and utilization of social support: theoretical perspectives and an empirical test. Soc. Sci. Med. 1989, 28(12):1221-1228.
26. George L.K. Economic status and subjective well-being: a review of the literature and an agenda for future research. Aging, Money, and Life Satisfaction 1992, 69-99. Springer, New York. N.E. Cutler, D.W. Grigg, M.P. Lawton (Eds.).
27. Gunnar M.R., Brodersen L., Nachmias M., Buss K., Rigatuso J. Stress reactivity and attachment security. Dev. Psychobiol. 1996, 29(3):191-204.
28. Heinrichs M., Domes G. Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans. Prog. Brain Res. 2008, 170:337-350. 10.1016/S0079-6123(08)00428-7.
29. Heinrichs M., von Dawans B., Domes G. Oxytocin, vasopressin, and human social behavior. Front. Neuroendocrinol. 2009, 30(4):548-557. 10.1016/j.yfrne.2009.05.005.
30. Holman E.A., Silver R.C., Waitzkin H. Traumatic life events in primary care patients: a study in an ethnically-diverse sample. Arch. Fam. Med. 2000, 9:802-811.
31. Holman E.A., Silver R.C., Poulin M., Andersen J., Gil-Rivas V., McIntosh D.N. Terrorism, acute stress, and cardiovascular health. Arch. Gen. Psychiatry 2008, 65(1):73-80.
32. Holman E.A., Lucas-Thompson R.G., Lu T. Social constraints, genetic vulnerability, and mental health following collective stress. J. Trauma. Stress. 2011, 24(5):497-505. 10.1002/Jts.20671.
33. House J.S., Landis K.R., Umberson D. Social relationships and health. Science 1988, 241(4865):540-545.
34. Israel S., Lerer E., Shalev I., Uzefovsky F., Riebold M., Laiba E., Ebstein R.P. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS One 2009, 4(5):e5535. 10.1371/journal.pone.0005535.
35. Kessler R.C., Sonnega A., Bromet E., Hughes M., Nelson C.B. Posttraumatic stress disorder in the National Comorbidity Survey. Arch. Gen. Psychiatry 1995, 52(12):1048-1060.
36. Kim H.S., Sherman D.K., Sasaki J.Y., Xu J., Chu T.Q., Ryu C., Taylor S.E. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(36):15717-15721. 10.1073/pnas.1010830107.
37. Kogan A., Saslow L.R., Impett E.A., Oveis C., Keltner D., Saturn S.R. Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(48):19189-19192. 10.1073/pnas.1112658108.
38. Krause N. Assessing stress-buffering effects: a cautionary note. Psychol. Aging 1995, 10(4):518-526.
39. Lee D., Fairbank R. Let Our Community Reflect on the Past Year Without Intrusion 2000, March 30, Denver Post.
40. Litwin H., Landau R. Social network type and social support among the old-old. J. Aging Stud. 2000, 14(2):213-228. 10.1016/S0890-4065(00)80012-2.
41. Lucas-Thompson R. Marital conflict exposure in relation to adolescent emotional and physiological stress responses: evidence for different patterns of dysregulation. J. Res. Adolesc. 2012, 22:704-721.
42. Lucht M.J., Barnow S., Sonnenfeld C., Rosenberger A., Grabe H.J., Schroeder W., Rosskopf D. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33(5):860-866. 10.1016/j.pnpbp.2009.04.004.
43. MacKinnon D.P. Introduction to Statistical Mediation Analysis 2008, Lawrence Erlbaum Associates, New York.
44. MacKinnon D.P., Luecken L.J. How and for whom? Mediation and moderation in health psychology. Health Psychol. 2008, 27(2 Suppl.):S99-S100. (Suppl., S99). 10.1037/0278-6133.27.2.
45. McHorney C.A., Ware J.E., Raczek A.E. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med. Care 1993, 247-263.
46. McLaughlin K.A., Nandi A., Keyes K.M., Uddin M., Aiello A.E., Galea S., Koenen K.C. Home foreclosure and risk of psychiatric morbidity during the recent financial crisis. Psychol. Med. 2012, 42:1441-1448. 10.1017/S0033291711002613.
47. Meyer-Lindenberg A., Domes G., Kirsch P., Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat. Rev. Neurosci. 2011, 12(9):524-538. 10.1038/nrn3044.
48. Mills R.J., Grasmick H.G., Morgan C.S., Wenk D. The effects of gender, family satisfaction, and economic strain on psychological well-being. Fam. Relat. 1992, 41(4):440-445. 10.2307/585588.
49. Nolen-Hoeksema S. Emotion regulation and psychopathology: the role of gender. Annu. Rev. Clin. Psychol. 2012, 8:161-187. 10.1146/annurev-clinpsy-032511-143109.
50. Olff M., Langeland W., Witteveen A., Denys D. A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder. CNS Spectr. 2010, 15(8):522-530.
51. Pennebaker J.W., Harber K.D. A social stage model of collective coping - the Loma-Prieta earthquake and the Persian-Gulf-War. J. Soc. Issues 1993, 49(4):125-145.
52. Pitman R.K., Orr S.P., Lasko N.B. Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res. 1993, 48(2):107-117.
53. Preacher K.J., Curran P.J., Bauer D.J. Simple Intercepts, Simple Slopes, and Regions of Significant in MLR 2-Way Interactions 2006, (Web Page).
54. Rhee R.J. Terrorism risk in a post-9/11 economy: the convergence of capital markets, insurance, and government action. Ariz. St. L.J. 2005, 435:467-473.
55. Riem M.M., Pieper S., Out D., Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying. Soc. Cogn. Affect. Neurosci. 2011, 6(3):294-300. 10.1093/scan/nsq035.
56. Rodrigues S.M., Saslow L.R., Garcia N., John O.P., Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(50):21437-21441. 10.1073/pnas.0909579106.
57. Ruggiero K.J., Del Ben K., Scotti J.R., Rabalais A.E. Psychometric properties of the PTSD checklist - Civilian Version. [Clinical Trial Research Support, Non-U.S. Gov't]. J. Trauma. Stress. 2003, 16(5):495-502. 10.1023/A:1025714729117.
58. Saphire-Bernstein S., Way B.M., Kim H.S., Sherman D.K., Taylor S.E. Oxytocin receptor gene (OXTR) is related to psychological resources. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(37):15118-15122. 10.1073/pnas.1113137108.
59. Sasaki J.Y., Kim H.S., Xu J. Religion and well-being: the moderating role of culture and the oxytocin receptor (OXTR) gene. J. Cross Cult Psychol 2011, 42:1394-1405. 10.1177/0022022111412526.
60. Serido J., Almeida D.M., Wethington E. Chronic stressors and daily hassles: unique and interactive relationships with psychological distress. J. Heal. Soc. Behav. 2004, 45(1):17-33.
61. Shedd O.L., Sears S.F., Harvill J.L., Arshad A., Conti J.B., Steinberg J.S., Curtis A.B. The world trade center attack: increased frequency of defibrillator shocks for ventricular arrhythmias in patients living remotely from New York City. J. Am. Coll. Cardiol. 2004, 44(6):1265-1267. 10.1016/j.jacc.2004.04.058.
62. Silver R.C., Holman E.A., McIntosh D.N., Poulin M., Gil-Rivas V. Nationwide longitudinal study of psychological responses to September 11. JAMA 2002, 288(10):1235-1244.
63. Silver R.C., Holman E.A., McIntosh D.N., Poulin M., Gil-Rivas V., Pizarro J. Coping with a national trauma: a nationwide longitudinal study of responses to the terrorist attacks of September 11. 9/11: Mental health in the Wake of Terrorist Attacks 2006, 45-70. Cambridge University Press, New York. Y. Neria, R. Gross, R. Marshall, E. Susser (Eds.).
64. Smith A.S., Wang Z. Salubrious effects of oxytocin on social stress-induced deficits. Horm. Behav. 2012, 61:320-330.
65. Stein M.B., Walker J.R., Hazen A.L., Forde D.R. Full and partial posttraumatic stress disorder: findings from a community survey. Am. J. Psychiatry 1997, 154(8):1114-1119.
66. Sturge-Apple M.L., Cicchetti D., Davies P.T., Suor J.H. Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes. [Research Support, N.I.H., Extramural]. J. Fam. Psychol. 2012, 26(3):431-442. 10.1037/a0028302.
67. Taylor S.E. Tend and befriend: biobehavioral bases of affiliation under stress. Curr. Dir. Psychol. Sci. 2006, 15(6):273-277.
68. Taylor S.E., Gonzaga G.C., Klein L.C., Hu P.F., Greendale G.A., Seeman T.E. Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom. Med. 2006, 68(2):238-245. 10.1097/01.psy.0000203242.95990.74.
69. Tost H., Kolachana B., Hakimi S., Lemaitre H., Verchinski B.A., Mattay V.S., Meyer-Lindenberg A. A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(31):13936-13941. 10.1073/pnas.1003296107.
70. Turner R.J., Sorenson A.M., Turner J.B. Social contingencies in mental health: a seven-year follow-up study of teenage mothers. J. Marriage Fam. 2000, 62(3):777-791. 10.1111/j.1741-3737.2000.00777.x.
71. Uchino B.N., Cacioppo J.T., Kiecolt-Glaser J.K. The relationship between social support and physiological processes: a review with emphasis on underlying mechanisms and implications for health. Psychol. Bull. 1996, 119(3):488-531.
72. US Department of Health and Human Services National Health Interview Survey Questionnaire 2000, National Center for Health Statistics, Hyattsville, MD.
73. Voydanoff P. Economic distress and family relations: a review of the 80s. J. Marriage Fam. 1990, 52(4):1099-1115. 10.2307/353321.
74. Ware J.E., Sherbourne C.D. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med. Care 1992, 30(6):473-483.
75. Ware J.E., Gandek B., Aaronson N.K., Acquadro C., Alonso J., Apolone G., Wooddauphinee S. The SF-36 Health Survey - development and use in mental-health research and the IQOLA Project. Int. J. Ment. Heal. 1994, 23(2):49-73.
76. Wayment H.A. It could have been me: vicarious victims and disaster-focused distress. Personal. Soc. Psychol. Bull. 2004, 30(4):515-528. 10.1177/0146167203261892.
77. Weathers F.W., Litz B.T., Herman D.S., Huska J.A., Keane T.M. The PTSD Checklist (PCL): Reliability, validity, and diagnostic utility 1993, Paper presented at the annual meeting of the International Society for Traumatic Stress Studies, San Antonio, TX, (October).
78. Wermter A.K., Kamp-Becker I., Hesse P., Schulte-Korne G., Strauch K., Remschmidt H. Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am. J. Med. Genet. 2010, 153B(2):629-639. 10.1002/ajmg.b.31032.
79. Wu S., Jia M., Ruan Y., Liu J., Guo Y., Shuang M., Zhang D. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol. Psychiatry 2005, 58(1):74-77. 10.1016/j.biopsych.2005.03.013.
80. Wu N., Li Z., Su Y. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J. Affect. Disord. 2012, 138(3):468-472. 10.1016/j.jad.2012.01.009.
81. Yatzkar U., Klein E. Intranasal oxytocin in patients with post traumatic stress disorder: a single dose, pilot double blind crossover study. Eur. Neuropsychopharmacol. 2010, 20:S84-S84.
82. Zeger S.L., Liang K.Y. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986, 42(1):121-130.