Sulfur dioxide upregulates the inhibited endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow

Biochemical and Biophysical Research Communications

Volumn 433, Issue 4, 2013, Pages 519-525

  Luo, Liman ^a   Liu, Die ^a   Tang, Chaoshu ^b,c   Du, Junbao ^a,c   Liu, Angie Dong ^d   Holmberg, Lukas ^d   Jin, Hongfang ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Hydrogen sulfide; Pulmonary hypertension; Pulmonary vascular remodeling; Sulfur dioxide

Indexed keywords

3 MERCAPTOPYRUVIC ACID; ASPARTATE AMINOTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; HYDROGEN SULFIDE; MESSENGER RNA; SULFUR DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; TREATMENT OUTCOME; UPREGULATION;

ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD PRESSURE; BLOTTING, WESTERN; CYSTATHIONINE BETA-SYNTHASE; CYSTATHIONINE GAMMA-LYASE; ENZYME ACTIVATION; HYDROGEN SULFIDE; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; LUNG; MALE; PULMONARY ARTERY; RATS; RATS, WISTAR; RNA, MESSENGER; SULFUR DIOXIDE; SULFURTRANSFERASES; UP-REGULATION;

RATTUS;

EID: 84876495949     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.014     Document Type: Article

References (31)

1. Forster T. Current issues in pulmonary hypertension. Orv. Hetil. 2012, 153:603-606.
2. Said S.I. Mediators and modulators of pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 2006, 291:L547-558.
3. Michelakis E.D., Wilkins M.R., Rabinovitch M. Emerging concepts and translational priorities in pulmonary arterial hypertension. Circulation 2008, 118:1486-1495.
4. Wei B., Du J., Li J., Qi J., Tang C. The modulating effect of L-arginine on collagen metabolism of pulmonary artery in pulmonary hypertension induced by a left-to-right shunt. Zhonghua Yi Xue Za Zhi 2002, 82:1273-1275.
5. Junbao D., Hui Y., Bing W., Jian L., Jianguang Q., Chaoshu T. Effect of l-arginine on collagen of high flow-induced pulmonary arterial remodeling. Circ. J. 2005, 69:603-608.
6. Bing W., Junbao D., Jianguang Q., Jian L., Chaoshu T. l-arginine impacts pulmonary vascular structure in rats with an aortocaval shunt. J. Surg. Res. 2002, 108:20-31.
7. Li X., Du J., Jin H., Geng B., Tang C. Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Heart Vessels 2008, 23:409-419.
8. Li W., Jin H.F., Jin H.F., Liu D., Sun J.H., Jian P.J., Li X.H., Tang C.S., DU J.B. Hydrogen sulfide induces apoptosis of pulmonary artery smooth muscle cell in rats with pulmonary hypertension induced by high pulmonary blood flow. Chin. Med. J. 2009, 122:3032-3038.
9. Du S.X., Jin H.F., Bu D.F., Zhao X., Geng B., Tang C.S., Du J.B. Endogenously generated sulfur dioxide and its vasorelaxant effect in rats. Acta Pharmacol. Sin. 2008, 29:923-930.
10. Luo Liman, Chen Stella, Jin Hongfang, Tang Chaoshu, Junbao Du Endogenous generation of sulfur dioxide in rat tissues. Biochem. Biophys. Res. Commun. 2011, 415:61-67.
11. Jin H.F., Du S.X., Zhao X., Wei H.L., Wang Y.F., Liang Y.F., Tang C.S., Du J.B. Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats. Acta Pharmacol. Sin. 2008, 29:1157-1166.
12. Sun Y., Tian Y., Prabha M., Liu D., Chen S., Zhang R., Liu X., Tang C., Jin H., Du J. Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling. Lab. Invest. 2010, 90:68-82.
13. Tang C., Li X., Du J. Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system. Curr. Vasc. Pharmacol. 2006, 4:17-22.
14. Wang Y., Zhao X., Jin H., Wei H., Li W., Bu D., Tang X., Ren Y., Tang C., Du J. Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice. Arterioscler. Thromb. Vasc. Biol. 2009, 29:73-179.
15. Li X.H., Bu D.F., Jin H.F., Ding Y.G., Du J.B., Li J., Tang C.S. The dynamic changes in endogeous hydrogen sulfide pathway at the early stage of pulmonary hypertension induced by high pulmonary flow in rats. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2007, 23:75-79.
16. Li X.H., Du J.B., Tang C.S. Impact of hydrogen sulfide donor on pulmonary vascular structure and vasoactive peptides in rats with pulmonary hypertension induced by high pulmonary blood flow. Acta Acad. Med. Sin. 2006, 28:159-163.
17. Zhang S., Du J., Jin H., Li W., Liang Y., Geng B., Li S., Zhang C., Tang C. Endogenous sulfur dioxide aggravates myocardial injury in isolated rat heart with ischemia and reperfusion. Transplantation 2009, 87:517-524.
18. Zhang R.Y., Du J.B., Sun Y., Chen S., Tsai H.J., Yuan L., Li L., Tang C.S., Jin H.F. Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes. Clin. Exp. Pharmacol. Physiol. 2011, 38:416-422.
19. Li W., Tang C., Jin H., Du J. Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats. Atherosclerosis 2011, 215:323-330.
20. Wang X.B., Huang X.M., Ochs T., Li X.Y., Jin H.F., Tang C.S., Du J.B. Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress. Basic Res. Cardiol. 2011, 106:865-878.
21. Wang X.B., Jin H.F., Tang C.S., Du J.B. Significance of endogenous sulfur-containing gases in the cardiovascular system. Clin. Exp. Pharmacol. Physiol. 2010, 37:745-752.
22. Lu W., Sun Y., Tang C., Ochs T., Qi J., Du J., Jin H. Sulfur dioxide derivatives improve the vasorelaxation in the spontaneously hypertensive rat by enhancing the vasorelaxant response to nitric oxide. Exp. Biol. Med. (Maywood) 2012, 237:867-872.
23. Liang Y., Liu D., Ochs T., Tang C., Chen S., Zhang S., Geng B., Jin H., Du J. Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. Lab. Invest. 2011, 91:12-23.
24. Chen S.S., Tang C.S., Jin H.F., Du J.B. Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system. Chin. Med. J. 2011, 124:1901-1905.
25. Chen S., Du J., Liang Y., Ochs T., Liu D., Zhu L., Tang X., Tang C., Jin H. Sulfur dioxide inhibits excessively activated endoplasmic reticulum stress in rats with myocardial injury. Heart Vessels 2012, 27:505-516.
26. Chen S., Du J., Liang Y., Zhang R., Tang C., Jin H. Sulfur dioxide restores calcium homeostasis disturbance in rat with isopoterenol-induced myocardial injury. Histol. Histopathol. 2012, 27:1219-1226.
27. Collin M., Thiemermann C. Hydrogen sulfide and sulfite: novel mediators in the pathophysiology of shock and inflammation. Shock 2005, 24:595-596.
28. Pettit F.H., Lyon D., Brown J.R., Shive W. Evidence for sulfite as an essential metabolite for human peripheral lymphocytes. Biochem. Biophys. Res. Commun. 1991, 179:611-614.
29. Li X.H., Du J.B., Bu D.F., Tang X.Y., Tang C.S. Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Acta Pharmacol. Sin. 2006, 27:971-980.
30. Mitsuhashi H., Yamashita S., Ikeuchi H., Kuroiwa T., Kaneko Y., Hiromura K., Ueki K., Nojima Y. Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neutrophils. Shock 2005, 24:529-534.
31. Mitsuhashi H., Nojima Y., Tanaka T., Ueki K., Maezawa A., Yano S., Naruse T. Sulfite is released by human neutrophils in response to stimulation with lipopolysaccharide. J. Leukoc. Biol. 1998, 64:595-599.