Sulfur dioxide derivatives improve the vasorelaxation in the spontaneously hypertensive rat by enhancing the vasorelaxant response to Nitric oxide

Experimental Biology and Medicine

Volumn 237, Issue 7, 2012, Pages 867-872

  Lu, Wei ^a   Sun, Yan ^a   Tang, Chaoshu ^b,c   Ochs, Todd ^d   Qi, Jianguang ^a   Du, Junbao ^a,c   Jin, Hongfang ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

Nitric oxide; Spontaneously hypertensive rat; Sulfur dioxide; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; ASPARTIC ACID BETA HYDROXAMIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM; SODIUM SULFITE; SULFUR DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; IN VIVO STUDY; INCUBATION TIME; MALE; NONHUMAN; PLETHYSMOGRAPHY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; THORACIC AORTA; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROPRUSSIDE; RATS; RATS, INBRED SHR; RATS, WISTAR; SULFUR DIOXIDE; VASODILATION;

EID: 84865316198     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.011304     Document Type: Article

References (29)

1. Julius S. Effect of sympathetic overactivity on cardiovascular prognosis in hypertension. Eur Heart J 1998;19(Suppl. F):F14-18.
2. Johns EJ. Role of angiotensin and the sympathetic nervous system in the control of renal function. J Hypertens 1989;7:695-701.
3. Dvoráková MC. Cardioprotective role of the VIP signaling system. Drug News Perspect 2005;18:387-91.
4. Chalmers J, Pilowsky P. Brainstem and bulbospinal neurotransmitter systems in the control of blood pressure. J Hypertens 1991;9:675-94.
5. Meng Z. Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide is a systemic oxidative damage agent. Inhal Toxicol 2003;15:181-95.
6. Meng Z, Qin G, Zhang B, Bai J. DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice. Mutagenesis 2004;119:465-8.
7. Meng Z, Liu Y. Cell morphological ultrastructural changes in various organs from mice exposed by inhalation to sulfur dioxide. Inhal Toxicol 2007;19:543-51.
8. Liu D, Jin H, Tang C, Du J. Sulfur dioxide: a novel gaseous signal in the regulation of cardiovascular functions. Mini Rev Med Chem 2010;10:1039-45.
9. Stipanuk MH. Metabolism of sulfur containing amino acids. Annu Rev Nutr 1986;6:179-209.
10. Stipanuk MH, Dominy JE Jr, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. J Nutr 2006;136(Suppl.):1652S-9S.
11. Ubuka T, Yuasa S, Ohta J, Masuoka N, Yao K, Kinuta M. Formation of sulfate from L-cysteine in rat liver mitochondria. Acta Med Okayama 1990;44:55-64.
12. Griffith OW. Cysteinesulfinate metabolism altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate. J Biol Chem 1983;258:1591-8.
13. Sun Y, Tian Y, Prabha M, Liu D, Chen S, Zhang R, Liu X, Tang C, Tang X, Jin H, Du J. Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling. Lab Invest 2010;90:68-82.
14. Zhao X, Jin HF, Tang CS, Du JB. Effects of sulfur dioxide, on the proliferation and apoptosis of aorta smooth muscle cells in hypertension: experiments with rats. Zhonghua Yi Xue Za Zhi 2008;88:1279-83.
15. Du SX, Jin HF, Bu DF, Bu DF, Zhao X, Geng B, Tang CS, Du JB. Endogenously generated sulfur dioxide and its vasorelaxant effect in rats. Acta Pharmacol Sin 2008;29:923-30.
16. Li J, Meng Z. The role of sulfur dioxide as an endogenous gaseous vasoactive factor in synergy with nitric oxide. Nitric Oxide 2009;20:166-74.
17. Li J, Li R, Meng Z. Sulfur dioxide upregulates the aortic nitric oxide pathway in rats. Eur J Pharmacol 2010;645:143-50.
18. Zhao W, Zhang J, Lu Y, Wang R. The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener. EMBO J 2001;20:6008-16.
19. Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 1997;237:527-31.
20. Mitsuhashi H, Ikeuchi H, Yamashita S, Kuroiwa T, Kaneko Y, Hiromura K, Ueki K, Nojima Y. Increased levels of serum sulfite in patients with acute pneumonia. Shock 2004;21:99-102.
21. Ji AJ, Savon SR, Jacobsen DW. Determination of total serum sulfite by HPLC with fluorescence detection. Clin Chem 1995;41:897-903.
22. Meng Z, Geng H, Bai J, Yan G. Blood pressure of rats lowered by sulfur dioxide and its derivatives. Inhal Toxicol 2003;15:951-9.
23. Meng Z, Zhang H. The vasodilator effect and its mechanism of sulfur dioxide derivatives on isolated aortic rings of rats. Inhal Toxicol 2007;19:979-86.
24. Meng Z, Li Y, Li J. Vasodilatation of sulfur dioxide derivatives and signal transduction. Arch Biochem Biophys 2007;467:291-6.
25. Mulvany MJ. Vascular growth in hypertension. J Cardiovasc Pharmacol 1992;20:S7-11.
26. Gohlke P, Lamberty V, Kuwer I, Bartenbach S, Schnell A, Unger T. Vascular remodeling in systemic hypertension. Am J Cardiol 1993;71:2E-7E.
27. Imai J, Souma M, Ozeki S, Suzuki T, Kaneko K. Reaction of dimerized NOx (x 1/41 or 2) with SO2 in a restricted slit-shaped micropore space. J Phys Chem 1991;95:9955-60.
28. Becker BF, Heindl B, Kupatt C, Zahler S. Endothelial function and hemostasis. Z Kardiol 2000;89:160-7.
29. Ignarro LJ, Buga GM, Wood KS, Byms RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9.