Presence of an extra chromosome alters meiotic double-stranded break repair dynamics and MLH1 foci distribution in human oocytes

Chromosoma

Volumn 122, Issue 1-2, 2013, Pages 93-102

  Robles, P ^a,c   Roig, I ^a   Garcia, R ^a   Brieno Enriquez M ^a   Martin, M ^a   Cabero, Ll ^b   Toran, N ^b   Garcia Caldes M ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL MATERNO INFANTIL VALL D HEBRON   (Spain)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DOUBLE STRANDED DNA; HISTONE H2AX; PROTEIN MLH1;

ANEUPLOIDY; ARTICLE; CASE REPORT; CHROMOSOME 21; CHROMOSOME PAIRING; CONTROLLED STUDY; CROSSING OVER; DNA REPAIR; FETUS; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; OOCYTE; PACHYTENE; PROTEIN LOCALIZATION; SUPERNUMERARY CHROMOSOME; SYNAPSE; TRISOMY 21;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CHROMOSOME PAIRING; CHROMOSOMES, HUMAN, PAIR 21; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MEIOSIS; NUCLEAR PROTEINS; OOCYTES; PACHYTENE STAGE; SYNAPTONEMAL COMPLEX; TRISOMY;

MAMMALIA; SYNAPSIS;

EID: 84876489160     PISSN: 00095915     EISSN: 14320886     Source Type: Journal    
DOI: 10.1007/s00412-012-0394-5     Document Type: Article

References (22)

1. Berchowitz LE, Copenhaver GP (2010) Genetic interference: don't stand so close to me. Curr Genomics 11:91-102
2. Borner GV, Kleckner N, Hunter N (2004) Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell 117:29-45
3. Cheng EY, Hunt PA, Naluai-Cecchini TA et al (2009) Meiotic recombination in human oocytes. PLoS Genet 5:e1000661
4. de Boer E, Stam P, Dietrich AJ, Pastink A, Heyting C (2006) Two levels of interference in mouse meiotic recombination. Proc Natl Acad Sci USA 103:9607-9612
5. Eaker S, Cobb J, Pyle A, Handel MA (2002) Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress. Dev Biol 249:85-95
6. Garcia-Cruz R, Roig I, Robles P, Scherthan H, Garcia Caldes M (2009) ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes. Reprod BioMed Online 18:37-44
7. Hunt PA, Hassold TJ (2008) Human female meiosis: what makes a good egg go bad? Trends Genet 24:86-93
8. Jones GH (1984) The control of chiasma distribution. Symp Soc Exp Biol 38:293-320
9. Lenzi ML, Smith J, Snowden T, Kim M, Fishel R, Poulos BK, Cohen PE (2005) Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis I in human oocytes. Am J Hum Genet 76:112-127
10. Mahadevaiah SK, Turner JMA, Baudat F, Rogakou EP, de Boer P, Blanco-Rodríguez J, Jasin M, Keeny S, Bonner W, Burgoyne PS (2001) Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet 27(3):271-276
11. Martínez-Flores I, Egozcue J, García M (2003) Synaptic process in rat (Rattus norvegicus): influence of the methodology on the results. Microsc Res Tech 60:450-457
12. Martinez-Perez E, Colaiacovo MP (2009) Distribution of meiotic recombination events: talking to your neighbors. Curr Opin Genet Dev 19:105-112
13. Moens PB, Marcon E, Shore JS, Kochakpour N, Spyropoulos B (2007) Initiation and resolution of interhomolog connections: crossover and non-crossover sites along mouse synaptonemal complexes. J Cell Sci 120:1017-1027
14. Plug AW, Peters AH, Xu Y, Keegan KS, Hoekstra MF, Baltimore D, de Boer P, Ashley T (1997) ATM and RPA in meiotic chromosome synapsis and recombination. Nat Genet 17:457-461
15. Prieto I, Tease C, Pezzi N, Buesa JM, Ortega S, Kremer L, Martínez A, Martínez-A C, Hultén MA, Barbero JL (2004) Cohesin component dynamics during meiotic prophase I in mammalian oocytes. Chromosom Res 12:197-213
16. Robles P, Roig I, Garcia R, Ortega A, Egozcue J, Cabero LL, Garcia M (2007) Pairing and synapsis in oocytes from female fetuses with euploid and aneuploid chromosome complements. Reproduction 133:899-907
17. Robles P, Roig I, Garcia R, Brieño M, Martin M, Barbero JL, Cabero L, Garcia Caldes M (2009) Analysis of recombination along chromosome 21 during human female pachytene stage. Reprod BioMed Online 18:784-794
18. Roig I, Liebe B, Egozcue J, Cabero L, Garcia M, Scherthan H (2004) Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes. Chromosoma 113:22-33
19. Roig I, Robles P, Garcia R, Martínez-Flores I, Egozcue J, Liebe B, Scherthan H, Garcia M (2005) Chromosome 18 behaviour in human trisomic oocytes. Presence of an extra chromosome extends bouquet stage. Reproduction 129:565-575
20. Tease C, Hulten MA (2004) Inter-sex variation in synaptonemal complex lengths largely determine the different recombination rates in male and female germ cells. Cytogenet Genome Res 107:208-215
21. Tease C, Hartshorne GM, Hultén MA (2002) Patterns of meiotic recombination in human fetal oocytes. Am J Hum Genet 70:1469-1479
22. Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS (2005) Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet 37:41-47