Silencing of unsynapsed meiotic chromosomes in the mouse

Nature Genetics

Volumn 37, Issue 1, 2005, Pages 41-47

  Turner, James M A ^a   Mahadevaiah, Shantha K ^a   Fernandez Capetillo, Oscar ^b   Nussenzweig, André ^b   Xu, Xiaoling ^c   Deng, Chu Xia ^c   Burgoyne, Paul S ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; BRCA1 PROTEIN; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME INACTIVATION; CHROMOSOME PAIRING; CHROMOSOME STRUCTURE; CONTROLLED STUDY; FETUS; GENE FUNCTION; GENE LOCATION; GENE SILENCING; MEIOSIS; MOUSE; NEUROSPORA; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SPERMATOCYTE; SYNAPSE; TRANSPOSON; X CHROMOSOME; Y CHROMOSOME;

ANIMALS; CELL CYCLE PROTEINS; CHROMOSOME PAIRING; DNA REPAIR; FEMALE; GENE SILENCING; GENES, BRCA1; HISTONES; MALE; MEIOSIS; MICE; OOCYTES; PROTEIN-SERINE-THREONINE KINASES; SPERMATOCYTES; TRANSLOCATION, GENETIC; X CHROMOSOME; Y CHROMOSOME;

ANIMALIA; MAMMALIA; NEUROSPORA; TRANSPOSONS;

EID: 11244350100     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1484     Document Type: Article

References (39)

1. Zickler, D. & Kleckner, N. Meiotic chromosomes: integrating structure and function. Annu. Rev. Genet. 33, 603-754 (1999).
2. de Boer, P. & de Jong, J.H. Chromosome pairing and fertility in mice, in Fertility and Chromosome Pairing: Recent Studies in Plants and Animals (ed. Gillies, C.B.) 37-76 (CRC Press, Boca Raton, Florida, 1989).
3. Burgoyne, P.S. & Mahadevaiah, S.K. Unpaired sex chromosomes and gametogenic failure. Chromosomes Today 11, 243-263 (1993).
4. Miklos, G.L.G. Sex chromosome pairing and male fertility. Cytogenet. Cell Genet. 13, 558-577 (1974).
5. Burgoyne, P.S. & Baker, T.G. Meiotic pairing and gametogenic failure, in Controlling Events in Meiosis, 38th Symposium of the Society for Experimental Biology (ed. Dickinson, H.G.) 349-362 (The Company of Biologists Ltd, Cambridge, 1984).
6. Roeder, S. & Bailis, J.M. The pachytene checkpoint. Trends Genet. 16, 395-403 (2000).
7. Xu, L., Weiner, B.M. & Kleckner, N. Meiotic cells monitor the status of the interhomolog recombination complex. Genes Dev. 11, 106-118 (1997).
8. Anderson, L.K., Stack, S.M. & Sherman, J.D. Spreading synaptonemal complexes from Zea mays. I. No synaptic adjustment of inversion loops during pachytene. Chromosoma 96, 295-305 (1988).
9. Moens, P.B. et al. The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination. J. Cell Sci. 115, 1611-1622 (2002).
10. Plug, A.W. et al. Changes in protein composition of meiotic nodules during mammalian meiosis. J. Cell Sci. 111, 413-423 (1998).
11. Ashley, T. An integration of old and new perspectives of mammalian meiotic sterility in Results and Problems in Cell Differentiation vol. 28 (ed. McElreavey, K.) 131-173 (Springer, Berlin, Heidelberg, 2000).
12. Keegan, K.S. et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10, 2423-2437 (1996).
13. Moens, P.B. et al. The association of ATR protein with mouse meiotic chromosome cores. Chromosoma 108, 95-102 (1999)
14. Scully, R. et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265-275 (1997).
15. Turner, J.M.A. et al. BRCA1, histone H2AX phosphorylation and male meiotic sex chromosome inactivation. Curr. Biol. (in the press).
16. Shiu, R.K., Raju, N.B., Zickler, D. & Metzenberg, R.L. Meiotic silencing by unpaired DNA. Cell 107, 905-916 (2001).
17. Lammers, J.H.M. et al. The gene encoding a major component of synaptonemal complexes of rat is related to X-linked lymphocyte-regulated genes. Mol. Cell. Biol. 14, 1137-1146 (1994).
18. Lyon, M.F. & Hawker, S.G. Reproductive lifespan in irradiated and unirradiated chromosomally XO mice. Genet. Res. 21, 185-194 (1973).
19. Burgoyne, P.S. & Baker, T.G. Oocyte depletion in XO mice and their XX sibs from 12 to 200 days post parfum. J. Reprod. Fertil. 61, 207-212 (1981).
20. Burgoyne, P.S. & Baker, T.G. Perinatal oocyte loss in XO mice and its implications for the aetiology of gonadal dysgenesis in XO women. J. Reprod. Fertil. 75, 633-645 (1985).
21. Speed, R.M. Oocyte development in XO foetuses of man and mouse: the possible role of heterologous X-chromosome pairing in germ cell survival. Chromosoma 94, 115-124 (1986).
22. Ford, C.E. & Evans, E.P. A reciprocal translocation in the mouse between the X chromosome and a short autosome. Cytogenetics 3, 295-305 (1964).
23. Odorisio, T., Rodriguez, T.A., Evans, E.P., Clarke, A.R. & Burgoyne, P.S. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis. Nat. Genet. 18, 257-261 (1998).
24. Xu, X., Aprelikova, O., Moens, P., Deng, C.X. & Furth, P.A. Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development 130, 2001-2012 (2003).
25. Xu, X. et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat. Genet. 28, 266-271 (2001).
26. Mahadevaiah, S.K. et al. Recombinational DNA double-strand breaks in mice precede synapsis. Nat. Genet. 27, 271-276 (2001).
27. Fernandez-Capetillo, O., Liebe, B., Scherthan, H. & Nussenzweig, A. H2AX regulates meiotic telomere clustering. J. Cell Biol. 163, 15-20 (2003).
28. Hall, L.L. et al. An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. Proc. Natl Acad. Sci. USA 99, 8677-8682 (2002).
29. Huynh, K.D. & Lee, J.T. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426, 857-862 (2003).
30. Moore, G.P. DNA-dependent RNA synthesis in fixed cells during spermatogenesis in mouse. Exp. Cell Res. 68, 462-465 (1971).
31. Handel, M.A. The XY body: a specialized meiotic chromatin domain. Exp. Cell Res. 296, 57-63 (2004).
32. Turner, J.M.A. et al. Analysis of male meiotic "sex-body" proteins during XY female meiosis provides new insights into their functions. Chromosoma 109, 426-432 (2000)
33. Wang, P.J. X chromosomes, retrogenes and their role in male reproduction. Trends Endocrinol. Metab. 15, 79-83 (2004).
34. Bean, C.J., Schaner, C.E. & Kelly, W.G. Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans. Nat. Genet. 36, 100-105 (2004).
35. Baarends, W.M. et al. Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol. Cell Biol. (in the press).
36. Mahadevaiah, S.K., Lovell-Badge, R. & Burgoyne, P.S. Tdy-negative XY, XXY and XYY female mice: breeding data and synaptonemal complex analysis. J. Reprod. Fertil. 97, 151-160 (1993).
37. Peters, A.H., Plug, A.W. & de Boer, P. Meiosis in carriers of heteromorphic bivalents: sex differences and implications for male fertility. Chromosome Res. 5, 313-324 (1997).
38. Burgoyne, P.S. & Evans, E.P. A high frequency of XO offspring from XPafY* male mice: evidence that the Paf mutation involves an inversion spanning the X PAR boundary. Cytogenet. Cell Genet. 91, 57-61 (2000).
39. Xu, X. et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat. Genet. 22, 37-43 (1999).