White matter hyperintensity volume and impaired mobility among older adults

Journal of Neurology

Volumn 260, Issue 3, 2013, Pages 884-890

  Willey, Joshua Z ^a   Scarmeas, Nikolaos ^a,b   Provenzano, Frank A ^a   Luchsinger, José A ^a,c   Mayeux, Richard ^a,b,c   Brickman, Adam M ^a,b  

^a Columbia University ^*  (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c NONE   (United States)

Author keywords

Aging; Gait speed; White matter hyperintensities

Indexed keywords

AGED; AGING; ARTICLE; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; FRONTAL LOBE; GAIT; GAIT DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVOUS SYSTEM PARAMETERS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK FACTOR; UNITED STATES; VASCULAR DISEASE; WHITE MATTER;

AGED; AGED, 80 AND OVER; AGING; BRAIN; COHORT STUDIES; FEMALE; GAIT; HUMANS; MALE; MOBILITY LIMITATION; MOVEMENT DISORDERS; NERVE FIBERS, MYELINATED; ORGAN SIZE; PROSPECTIVE STUDIES;

EID: 84876485959     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-012-6731-z     Document Type: Article

References (37)

1. Newman AB et al (2003) "Successful aging": effect of subclinical cardiovascular disease. Arch Intern Med 163(19):2315-2322
2. Bennett DA et al (1996) Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med 334(2):71-76
3. Odenheimer G et al (1994) Comparison of neurologic changes in 'successfully aging' persons vs the total aging population. Arch Neurol 51(6):573-580
4. Guralnik JM et al (2000) Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci 55(4):M221-M231
5. Gill TM et al (2004) The development of insidious disability in activities of daily living among community-living older persons. Am J Med 117(7):484-491
6. Scarmeas N et al (2009) Physical activity, diet, and risk of Alzheimer disease. JAMA 302(6):627-637
7. Hoxie RE, Rubenstein LZ (1994) Are older pedestrians allowed enough time to cross intersections safely? J Am Geriatr Soc 42(3):241-244
8. Verghese J et al (2008) Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc 56(7):1244-1251
9. Verghese J et al (2002) Abnormality of gait as a predictor of non-Alzheimer's dementia. N Engl J Med 347(22):1761-1768
10. McGinn AP et al (2008) Walking speed and risk of incident ischemic stroke among postmenopausal women. Stroke 39(4):1233-1239
11. Wilson RS et al (2002) Progression of gait disorder and rigidity and risk of death in older persons. Neurology 58(12):1815-1819
12. Okoro CA et al (2006) Association between the metabolic syndrome and its components and gait speed among U.S. adults aged 50 years and older: a cross-sectional analysis. BMC Public Health 6:282
13. Soumare A et al (2006) Cross-sectional association between homocysteine and motor function in the elderly. Neurology 67(6):985-990
14. Volpato S et al (2002) Comorbidities and impairments explaining the association between diabetes and lower extremity disability: the women's health and aging study. Diabetes Care 25(4):678-683
15. Arvanitakis Z et al (2004) Diabetes mellitus and progression of rigidity and gait disturbance in older persons. Neurology 63(6):996-1001
16. Baezner H et al (2008) Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 70(12):935-942
17. Longstreth WT Jr et al (2002) Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the cardiovascular health study. Stroke 33(10):2376-2382
18. Longstreth WT Jr et al (1996) Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The cardiovascular health study. Stroke 27(8):1274-1282
19. Zheng JJ et al (2011) Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review. Stroke 42(7):2086-2090
20. Srikanth V et al (2010) The location of white matter lesions and gait - a voxel-based study. Ann Neurol 67(2):265-269
21. Tang MX et al (2001) Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology 56(1):49-56
22. Brickman AM et al (2008) Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan. Arch Neurol 65(8):1053-1061
23. Reitz C et al (2009) Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites. Arch Neurol 66(7):834-840
24. Stern Y et al (1992) Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education. Arch Neurol 49(5):453-460
25. Scarmeas N et al (2011) Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. Ann Neurol 69(2):257-268
26. Brickman AM, Muraskin J, Zimmerman ME (2009) Structural neuroimaging in Altheimer's disease: do white matter hyperintensities matter? Dialogues Clin Neurosci 11(2):181-190
27. Brickman AM et al (2011) Quantitative approaches for assessment of white matter hyperintensities in elderly populations. Psychiatry Res 193(2):101-106
28. Admiraal-Behloul F et al (2005) Fully automatic segmentation of white matter hyperintensities in MR images of the elderly. Neuroimage 28(3):607-617
29. Massaro JM et al (2004) Managing and analysing data from a large-scale study on Framingham offspring relating brain structure to cognitive function. Stat Med 23(2):351-367
30. Blum S et al (2012) Memory after silent stroke: hippocampus and infarcts both matter. Neurology 78(1):38-46
31. Studenski S et al (2011) Gait speed and survival in older adults. JAMA 305(1):50-58
32. Schmid A et al (2007) Improvements in speed-based gait classifications are meaningful. Stroke 38(7):2096-2100
33. Baloh RW, Vinters HV (1995) White matter lesions and disequilibrium in older people II. Clinicopathologic correlation. Arch Neurol 52(10):975-981
34. Brown WR et al (2002) Venous collagenosis and arteriolar tortuosity in leukoaraiosis. J Neurol Sci 203-204:159-163
35. Enzinger C et al (2009) Brain activity changes associated with treadmill training after stroke. Stroke 40(7):2460-2467
36. Luft AR et al (2008) Treadmill exercise activates subcortical neural networks and improves walking after stroke: a randomized controlled trial. Stroke 39(12):3341-3350
37. Longstreth WT Jr et al (2005) Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the cardiovascular health study. Stroke 36(1):56-61