Memory after silent stroke: Hippocampus and infarcts both matter

Neurology

Volumn 78, Issue 1, 2012, Pages 38-46

  Blum, S ^a,b   Luchsinger, J A ^b   Manly, J J ^a,b   Schupf, N ^a,b,c   Stern, Y ^a,b   Brown, T R ^d   DeCarli, C ^e   Small, S A ^a,b   Mayeux, R ^a,b,c   Brickman, A M ^a,b  

^a Department of Epidemiology   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^c Mailman School of Public Health   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BRAIN INFARCTION; BRAIN SIZE; COGNITION; DEPTH PERCEPTION; DISEASE ASSOCIATION; FEMALE; HIPPOCAMPUS; HUMAN; LANGUAGE; MAJOR CLINICAL STUDY; MALE; MEMORY; MEMORY DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCORING SYSTEM; STROKE; PATHOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; CEREBRAL INFARCTION; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; PROSPECTIVE STUDIES; STROKE;

EID: 84856603454     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31823ed0cc     Document Type: Article

References (39)

1. Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch Neurol 2001;58:1395-1402. (Pubitemid 32845990)
2. Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science 1997;278:412-419. (Pubitemid 27454417)
3. Golomb J, de Leon MJ, Kluger A, George AE, Tarshish C, Ferris SH. Hippocampal atrophy in normal aging: an association with recent memory impairment. Arch Neurol 1993;50:967-973. (Pubitemid 23275125)
4. Schneider JA, Wilson RS, Cochran EJ, et al. Relation of cerebral infarctions to dementia and cognitive function in older persons. Neurology 2003;60:1082-1088. (Pubitemid 36418764)
5. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003;348: 1215-1222. (Pubitemid 36359297)
6. Reitz C, Luchsinger JA, Tang MX, Manly J, Mayeux R. Stroke and memory performance in elderly persons without dementia. Arch Neurol 2006;63:571-576.
7. Saczynski JS, Sigurdsson S, Jonsdottir MK, et al. Cerebral infarcts and cognitive performance: importance of location and number of infarcts. Stroke 2009;40:677-682.
8. Arvanitakis Z, Leurgans SE, Barnes LL, Bennett DA, Schneider JA. Microinfarct pathology, dementia, and cognitive systems. Stroke 2011;42:722-727.
9. Carey CL, Kramer JH, Josephson SA, et al. Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly. Stroke 2008;39:397-402. (Pubitemid 351619462)
10. Tatemichi TK, Desmond DW, Prohovnik I. Strategic infarcts in vascular dementia. A clinical and brain imaging experience. Arzneimittelforschung 1995;45:371-385.
11. Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007;69: 2197-2204.
12. van de Pol LA, Korf ES, van der Flier WM, et al. Magnetic resonance imaging predictors of cognition in mild cognitive impairment. Arch Neurol 2007;64:1023-1028.
13. Jack CR, Jr., Petersen RC, Xu YC, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 1999;52:1397-1403. (Pubitemid 29190530)
14. Manns JR, Eichenbaum H. Evolution of declarative memory. Hippocampus 2006;16:795-808. (Pubitemid 44473593)
15. Schmidt-Kastner R, Freund TF. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991; 40:599-636.
16. Wu W, Brickman AM, Luchsinger J, et al. The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life. Ann Neurol 2008;64: 698-706.
17. Tang MX, Cross P, Andrews H, et al. Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology 2001;56:49-56. (Pubitemid 32059651)
18. Brickman AM, Schupf N, Manly JJ, et al. Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan. Arch Neurol 2008;65: 1053-1061.
19. Stern Y, Andrews H, Pittman J, et al. Diagnosis of dementia in a heterogeneous population: development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education. Arch Neurol 1992;49:453-460.
20. Siedlecki KL, Honig LS, Stern Y. Exploring the structure of a neuropsychological battery across healthy elders and those with questionable dementia and Alzheimer's disease. Neuropsychology 2008;22:400-411. (Pubitemid 351645180)
21. Siedlecki KL, Manly JJ, Brickman AM, Schupf N, Tang MX, Stern Y. Do neuropsychological tests have the same meaning in Spanish speakers as they do in English speakers? Neuropsychology 2010;24:402-411.
22. Buschke H, Fuld PA. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 1974;24:1019-1025.
23. DeCarli C, Maisog J, Murphy DG, Teichberg D, Rapoport SI, Horwitz B. Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr 1992;16:274-284.
24. DeCarli C, Massaro J, Harvey D, et al. Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal. Neurobiol Aging 2005; 26:491-510. (Pubitemid 40093933)
25. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004;256:183-194. (Pubitemid 39222988)
26. Heaton RK, Grant I, Matthews CG, and Adams KM. Differences in neuropsychological test performance associated with age, education, and sex. In: Neuropsychological Assessment of Neuropsychiatric Disorders. New York: Oxford University Press; 1986:100-120.
27. Manly JJ, Jacobs DM, Sano M, et al. Cognitive test performance among nondemented elderly African Americans and whites. Neurology 1998;50:1238-1245. (Pubitemid 28240334)
28. Brickman AM, Siedlecki KL, Muraskin J, et al. White matter hyperintensities and cognition: testing the reserve hypothesis. Neurobiol Aging 2011;32:1588-1598.
29. Grabowski TJ, Damasio AR. Definition, Clinical Features and Neuroanatomical Basis of Dementia. Cambridge, UK: Cambridge University Press; 2004:1-33.
30. Gainotti G, Acciarri A, Bizzarro A, et al. The role of brain infarcts and hippocampal atrophy in subcortical ischaemic vascular dementia. Neurol Sci 2004;25:192-197. (Pubitemid 39485606)
31. Fein G, Di Sclafani V, Tanabe J, et al. Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology 2000;55:1626-1635.
32. Jellinger KA. The pathology of ischemic-vascular dementia: an update. J Neurol Sci 2002;203-204:153-157. (Pubitemid 35287392)
33. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease: The Nun Study. JAMA 1997;277:813-817. (Pubitemid 27111317)
34. Jagust WJ, Zheng L, Harvey DJ, et al. Neuropathological basis of magnetic resonance images in aging and dementia. Ann Neurol 2008;63:72-80. (Pubitemid 351240553)
35. Chui HC, Zarow C, Mack WJ, et al. Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Ann Neurol 2006;60:677-687. (Pubitemid 46048485)
36. Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R. Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology 2005;65:545-551. (Pubitemid 41170713)
37. Honig LS, Tang MX, Albert S, et al. Stroke and the risk of Alzheimer disease. Arch Neurol 2003;60:1707-1712. (Pubitemid 37521623)
38. Desikan RS, Sabuncu MR, Schmansky NJ, et al. Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One 2010;5:e12853.
39. Reitz C, Schupf N, Luchsinger JA, et al. Validity of selfreported stroke in elderly African Americans, Caribbean Hispanics, and whites. Arch Neurol 2009;66:834-840.