Effects of grape seed polyphenols on oxidative damage in liver tissue of acutely and chronically exercised rats

Phytotherapy Research

Volumn 27, Issue 5, 2013, Pages 672-677

  Belviranli, Muaz ^a   Gökbel, Hakki ^a   Okudan, Nilsel ^a   Büyükbaş, Sadik ^a  

^a SELCUK UNIVERSITY   (Turkey)

Author keywords

exercise; grape seed extract; liver; oxidative stress

Indexed keywords

ACTIVIN; GRAPE SEED EXTRACT; MALONALDEHYDE; NITRIC OXIDE; POLYPHENOL; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; EXHAUSTION; LIVER INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RUNNING; TREADMILL EXERCISE;

ANIMALS; ANTIOXIDANTS; GRAPE SEED EXTRACT; LIVER; MALE; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; POLYPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; XANTHINE OXIDASE;

RATTUS; VITACEAE;

EID: 84876464382     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4772     Document Type: Article

References (46)

1. Ashton T, Rowlands CC, Jones E, et al,. 1998. Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise. Eur J Appl Physiol Occup Physiol 77: 498-502.
2. Aydin C, Ince E, Koparan S, Cangul IT, Naziroglu M, Ak F,. 2007. Protective effects of long term dietary restriction on swimming exercise-induced oxidative stress in the liver, heart and kidney of rat. Cell Biochem Funct 25: 129-137.
3. Bagchi D, Bagchi M, Stohs SJ, et al,. 2000. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-197.
4. Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ,. 1997. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95: 179-189.
5. Bejma J, Ji LL,. 1999. Aging and acute exercise enhance free radical generation in rat skeletal muscle. J Appl Physiol 87: 465-470.
6. Bloomer RJ, Goldfarb AH,. 2004. Anaerobic exercise and oxidative stress: A review. Can J Appl Physiol 29: 245-263.
7. Bravo L,. 1998. Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56: 317-333.
8. Burneiko RC, Diniz YS, Galhardi CM, et al,. 2006. Interaction of hypercaloric diet and physical exercise on lipid profile, oxidative stress and antioxidant defenses. Food Chem Toxicol 44: 1167-1172.
9. Cakir B, Kasimay O, Kolgazi M, Ersoy Y, Ercan F, Yeǧen BC,. 2010. Stress-induced multiple organ damage in rats is ameliorated by the antioxidant and anxiolytic effects of regular exercise. Cell Biochem Funct 28: 469-479.
10. Choi EY, Cho YO,. 2007. The effects of physical training on antioxidative status under exercise-induced oxidative stress. Nutr Res Pract 1: 14-18.
11. Chung HY, Yu BP,. 2000. Significance of hepatic xanthine oxidase and uric acid in age and dietary restricted rats. Age 23: 123-128.
12. Cortas NK, Wakid NW,. 1990. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 36: 1440-1443.
13. Da Silva LA, Pinho CA, Rocha LG, Tuon T, Silveira PC, Pinho RA,. 2009. Effect of different models of physical exercise on oxidative stress markers in mouse liver. Appl Physiol Nutr Metab 34: 60-65.
14. Demirkaya E, Avci A, Kesik V, et al,. 2009. Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity. Can J Physiol Pharmacol 87: 633-640.
15. Demrow HS, Slane PR, Folts JD,. 1995. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 91: 1182-1188.
16. Divald A, Powell SR,. 2006. Proteasome mediates removal of proteins oxidized during myocardial ischemia. Free Radic Biol Med 40: 156-164.
17. El-Alfy AT, Ahmed AA, Fatani AJ,. 2005. Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacol Res 52: 264-270.
18. Ficicilar H, Zergeroglu AM, Tekin D, Ersoz G,. 2003. The effects of acute exercise on plasma antioxidant status and platelet response. Thromb Res 111: 267-271.
19. Ghiselli A, Serafini M, Natella F, Scaccini C,. 2000. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 29: 1106-1114.
20. Ho KP, Xiao DS, Ke Y, Qian ZM,. 2001. Exercise decreases cytosolic aconitase activity in the liver, spleen, and bone marrow in rats. Biochem Biophys Res Commun 282: 264-267.
21. Huang CC, Lin TJ, Lu YF, Chen CC, Huang CY, Lin WT,. 2009. Protective effects of L-arginine supplementation against exhaustive exercise-induced oxidative stress in young rat tissues. Chin J Physiol 52: 306-315.
22. Huang CC, Tsai SC, Lin WT,. 2008. Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Exp Gerontol 43: 571-577.
23. Ji LL,. 1999. Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 222: 283-292.
24. Ji LL,. 1995. Oxidative stress during exercise: implication of antioxidant nutrients. Free Radic Biol Med 18: 1079-1086.
25. Joshi SS, Kuszynski CA, Bagchi M, Bagchi D,. 2000. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology 155: 83-90.
26. Kakarla P, Vadluri G, Reddy Kesireddy S,. 2005. Response of hepatic antioxidant system to exercise training in aging female rat. J Exp Zool A Comp Exp Biol 303: 203-208.
27. Kayatekin BM, Gönenç S, Açikgöz O, Uysal N, Dayi A,. 2002. Effects of sprint exercise on oxidative stress in skeletal muscle and liver. Eur J Appl Physiol 87: 141-144.
28. Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V,. 2001. Method for the measurement of antioxidant activity in human fluids. J Clin Pathol 54: 356-361.
29. Liu J, Yeo HC, Overvik-Douki E, et al,. 2000. Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol 89: 21-28.
30. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ,. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
31. Mallikarjuna K, Nishanth K, Hou CW, Kuo CH, Sathyavelu Reddy K,. 2009. Effect of exercise training on ethanol-induced oxidative damage in aged rats. Alcohol 43: 59-64.
32. Minato K, Miyake Y, Fukumoto S, et al,. 2003. Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci 72: 1609-1616.
33. Ogonovszky H, Sasvári M, Dosek A, et al,. 2005. The effects of moderate, strenuous, and overtraining on oxidative stress markers and DNA repair in rat liver. Can J Appl Physiol 2005 30: 186-195.
34. Oztasan N, Taysi S, Gumustekin K, et al,. 2004. Endurance training attenuates exercise-induced oxidative stress in erythrocytes in rat. Eur J Appl Physiol 91: 622-627.
35. Polidori MC, Mecocci P, Cherubini A, Senin U,. 2000. Physical activity and oxidative stress during aging. Int J Sports Med 21: 154-157.
36. Prajda N, Weber G,. 1975. Malignant transformation-linked imbalace: Decreased XO activity in hepatomas. FEBS Lett 59: 245-249.
37. Qian ZM, Xiao DS, Ke Y, Liao QK,. 2001. Increased nitric oxide is one of the causes of changes of iron metabolism in strenuously exercised rats. Am J Physiol Regul Integr Comp Physiol 280: 739-743.
38. Radák Z, Asano K, Inoue M, et al,. 1996. Superoxide dismutase derivative prevents oxidative damage in liver and kidney of rats induced by exhausting exercise. Eur J Appl Physiol Occup Physiol 72: 189-194.
39. Rice-Evans CA, Miller NJ, Paganga G,. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20: 933-956.
40. Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP, Rice-Evans C,. 1995. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys 322: 339-346.
41. Sen CK, Bagchi D,. 2001. Regulation of inducible adhesion molecule expression in human endothelial cells by grape seed proanthocyanidin extract. Mol Cell Biochem 216: 1-7.
42. Sen CK, Marin E, Kretzschmar M, Hänninen O,. 1992. Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization. J Appl Physiol 73: 1265-1272.
43. Shao ZH, Hsu CW, Chang WT, et al,. 2006. Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide. Cell Biol Toxicol 22: 149-158.
44. Sharp PE, La Regina MC,. 1998. The laboratory rat. In:, Suckow MA, (ed). CRC Press LLC: Boca-Raton, Florida; 17.
45. Wasowicz W, Nève J, Peretz A,. 1993. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem 39: 2522-2526.
46. Xiao DS, Ho KP, Qian ZM,. 2004. Nitric oxide inhibition decreases bleomycin-detectable iron in spleen, bone marrow cells and heart but not in liver in exercise rats. Mol Cell Biochem 260: 31-37.