Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers: Analysis of intragastric fluid dynamics and drug absorption

Pharmaceutical Research

Volumn 30, Issue 4, 2013, Pages 951-958

  Yamashita, Shinji ^a   Kataoka, Makoto ^a   Higashino, Haruki ^a   Sakuma, Shinji ^a   Sakamoto, Takashi ^b   Uchimaru, Hinako ^b   Tsukikawa, Hiroshi ^b   Shiramoto, Masanari ^b   Uchiyama, Hitoshi ^c   Tachiki, Hidehisa ^c   Irie, Shin ^b  

^a SETSUNAN UNIVERSITY   (Japan)

^b LTA Clinical Pharmacology Center   (Japan)

^c National Cerebral and Cardiovascular Center 30602   (Japan)

Author keywords

drug absorption; fluid dynamics; gastric emptying; gastric pH; stomach

Indexed keywords

ATENOLOL; SALICYLIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CONCENTRATION; DRUG HALF LIFE; DRUG STOMACH LEVEL; DYNAMICS; HUMAN; HUMAN EXPERIMENT; INTESTINE; INTRAGASTRIC FLUID DYNAMICS; KINETICS; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STEADY STATE; STOMACH EMPTYING; STOMACH JUICE; STOMACH SECRETION; VOLUNTEER;

ADULT; ATENOLOL; GASTRIC EMPTYING; HALF-LIFE; HUMANS; HYDRODYNAMICS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KINETICS; MALE; SALICYLIC ACID; STOMACH; YOUNG ADULT;

EID: 84876462343     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0931-1     Document Type: Article

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