LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice

Clinical and Experimental Metastasis

Volumn 30, Issue 4, 2013, Pages 483-495

  Li, Rong ^a   Doherty, Judy ^b,e   Antonipillai, Juliana ^a   Chen, Sheng ^a   Devlin, Mark ^b,e   Visser, Kathryn ^b,e   Baell, Jonathan ^c,e   Street, Ian ^c,d,e   Anderson, Robin L ^b,d   Bernard, Ora ^a,d  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e University of Melbourne   (Australia)

Author keywords

Actin cytoskeleton; Breast cancer; LIM kinase inhibitors; Metastasis; Therapy

Indexed keywords

ANTINEOPLASTIC AGENT; BMS3; COFILIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; LIM KINASE; LIM KINASE 1; MYOSIN LIGHT CHAIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BREAST CANCER; BREAST METASTASIS; CANCER GROWTH; CANCER INVASION; CANCER PATIENT; CELL MIGRATION; CELL MOTILITY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; LIMIT OF QUANTITATION; LIVER METASTASIS; LUNG WEIGHT; LYMPHOCYTE PROLIFERATION; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SPLEEN WEIGHT; TUMOR GROWTH; VASCULAR ENDOTHELIUM; WEIGHT REDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; ENZYME INHIBITORS; FEMALE; GENES, DOMINANT; HUMANS; IMMUNOENZYME TECHNIQUES; LIM KINASES; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84876460674     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-012-9553-6     Document Type: Article

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