-
3
-
-
0019877129
-
Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture
-
Rijken DC, Collen D: Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture. J Biol Chem 1981; 256: 7035-7041.
-
(1981)
J Biol Chem
, vol.256
, pp. 7035-7041
-
-
Rijken, D.C.1
Collen, D.2
-
4
-
-
5144220471
-
Tissue-type plasminogen activator: A historical perspective and personal account
-
Collen D, Lijnen HR: Tissue-type plasminogen activator: A historical perspective and personal account. J Thromb Haemost 2004; 2: 541-546.
-
(2004)
J Thromb Haemost
, vol.2
, pp. 541-546
-
-
Collen, D.1
Lijnen, H.R.2
-
5
-
-
0028783948
-
The national institute of neurological disorders and stroke rt-pa stroke study group
-
Tissue plasminogen activator for acute ischemic stroke
-
Tissue plasminogen activator for acute ischemic stroke: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995; 333: 1581-1587.
-
(1995)
N Engl J Med
, vol.333
, pp. 1581-1587
-
-
-
6
-
-
77952854316
-
Stroke: Working toward a prioritized world agenda
-
Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, et al: Stroke: Working toward a prioritized world agenda. Cerebrovasc Dis 2010; 30: 127-147.
-
(2010)
Cerebrovasc Dis
, vol.30
, pp. 127-147
-
-
Hachinski, V.1
Donnan, G.A.2
Gorelick, P.B.3
Hacke, W.4
Cramer, S.C.5
Kaste, M.6
-
7
-
-
84870788484
-
Stroke: Advances in thrombolysis
-
Kaste M: Stroke: Advances in thrombolysis. Lancet Neurol 2013; 12: 2-4.
-
(2013)
Lancet Neurol
, vol.12
, pp. 2-4
-
-
Kaste, M.1
-
8
-
-
84959808645
-
The fibrinolytic activity of hemolytic streptococci
-
Tillett WS, Garner RL: The fibrinolytic activity of hemolytic streptococci. J Exp Med 1933; 58: 485-502.
-
(1933)
J Exp Med
, vol.58
, pp. 485-502
-
-
Tillett, W.S.1
Garner, R.L.2
-
9
-
-
12144254395
-
A history of thrombolytic therapy
-
Ouriel K: A history of thrombolytic therapy. J Endovasc Ther 2004; 11(suppl 2):II128-II133.
-
(2004)
J Endovasc Ther
, vol.11
, Issue.SUPPL. 2
-
-
Ouriel, K.1
-
10
-
-
35848965673
-
A history of streptokinase use in acute myocardial infarction
-
Sikri N, Bardia A: A history of streptokinase use in acute myocardial infarction. Tex Heart Inst J 2007; 34: 318-327.
-
(2007)
Tex Heart Inst J
, vol.34
, pp. 318-327
-
-
Sikri, N.1
Bardia, A.2
-
11
-
-
0000585887
-
The intravenous infusion of the streptococcal fibrinolytic principle (streptokinase) into patients
-
Tillett WS, Johnson AJ, McCarty WR: The intravenous infusion of the streptococcal fibrinolytic principle (streptokinase) into patients. J Clin Invest 1955; 34: 169-185.
-
(1955)
J Clin Invest
, vol.34
, pp. 169-185
-
-
Tillett, W.S.1
Johnson, A.J.2
McCarty, W.R.3
-
12
-
-
0001526346
-
Fibrinolytic activity of normal urine
-
Macfarlane RG, Pilling J: Fibrinolytic activity of normal urine. Nature 1947; 159: 779.
-
(1947)
Nature
, vol.159
, pp. 779
-
-
Macfarlane, R.G.1
Pilling, J.2
-
13
-
-
0000737856
-
Staphylokinase: An activator of plasma protease
-
Lack CH: Staphylokinase: An activator of plasma protease. Nature 1948; 161: 559.
-
(1948)
Nature
, vol.161
, pp. 559
-
-
Lack, C.H.1
-
14
-
-
0000458034
-
Thrombolysis with fibrinolysin in cerebral arterial occlusion
-
Sussman BJ, Fitch TS: Thrombolysis with fibrinolysin in cerebral arterial occlusion. JAMA 1958; 167: 1705-1709.
-
(1958)
JAMA
, vol.167
, pp. 1705-1709
-
-
Sussman, B.J.1
Fitch, T.S.2
-
15
-
-
0017285123
-
A pilot study of urokinase therapy in cerebral infarction
-
Fletcher AP, Alkjaersig N, Lewis M, Tulevski V, Davies A, Brooks JE, et al: A pilot study of urokinase therapy in cerebral infarction. Stroke 1976; 7: 135-142.
-
(1976)
Stroke
, vol.7
, pp. 135-142
-
-
Fletcher, A.P.1
Alkjaersig, N.2
Lewis, M.3
Tulevski, V.4
Davies, A.5
Brooks, J.E.6
-
16
-
-
0000860421
-
Therapeutic thrombolysis in cerebral thromboembolism Double-blind evaluation of intravenous plasmin therapy in carotid and middle cerebral arterial occlusion
-
Meyer JS, Gilroy J, Barnhart MI, Johnson JF: Therapeutic thrombolysis in cerebral thromboembolism. Double-blind evaluation of intravenous plasmin therapy in carotid and middle cerebral arterial occlusion. Neurology 1963; 13: 927-937.
-
(1963)
Neurology
, vol.13
, pp. 927-937
-
-
Meyer, J.S.1
Gilroy, J.2
Barnhart, M.I.3
Johnson, J.F.4
-
17
-
-
0001577135
-
Anticoagulants plus streptokinase therapy in progressive stroke
-
Meyer JS, Gilroy J, Barnhart MI, Johnson JF: Anticoagulants plus streptokinase therapy in progressive stroke. JAMA 1964; 189: 373.
-
(1964)
JAMA
, vol.189
, pp. 373
-
-
Meyer, J.S.1
Gilroy, J.2
Barnhart, M.I.3
Johnson, J.F.4
-
18
-
-
0028847213
-
Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke: Multicentre acute stroke trial y italy (mast-i) group
-
Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke: Multicentre Acute Stroke Trial Y Italy (MAST-I) Group. Lancet 1995; 346: 1509-1514.
-
(1995)
Lancet
, vol.346
, pp. 1509-1514
-
-
-
19
-
-
0000945065
-
Thrombolytic therapy with streptokinase in acute ischemic stroke: Multicenter acute stroke trial y europe study group
-
Thrombolytic therapy with streptokinase in acute ischemic stroke: Multicenter Acute Stroke Trial Y Europe study group. N Engl J Med 1996; 335: 145-150.
-
(1996)
N Engl J Med
, vol.335
, pp. 145-150
-
-
-
20
-
-
0022485609
-
Controlled trial of combined urokinase and dextran sulfate therapy in patients with acute cerebral infarction
-
Fujishima M, Omae T, Tanaka K, Iino K, Matsuo O, Mihara H: Controlled trial of combined urokinase and dextran sulfate therapy in patients with acute cerebral infarction. Angiology 1986; 37: 487-498.
-
(1986)
Angiology
, vol.37
, pp. 487-498
-
-
Fujishima, M.1
Omae, T.2
Tanaka, K.3
Iino, K.4
Matsuo, O.5
Mihara, H.6
-
21
-
-
0026440559
-
Thrombolysis in acute ischemic stroke: Does it work?
-
Wardlaw JM, Warlow CP: Thrombolysis in acute ischemic stroke: Does it work? Stroke 1992; 23: 1826-1839.
-
(1992)
Stroke
, vol.23
, pp. 1826-1839
-
-
Wardlaw, J.M.1
Warlow, C.P.2
-
22
-
-
0021360341
-
Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardial infarction
-
Van de Werf F, Ludbrook PA, Bergmann SR, Tiefenbrunn AJ, Fox KA, de Geest H, et al: Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardial infarction. N Engl J Med 1984; 310: 609-613.
-
(1984)
N Engl J Med
, vol.310
, pp. 609-613
-
-
Van De Werf, F.1
Ludbrook, P.A.2
Bergmann, S.R.3
Tiefenbrunn, A.J.4
Fox, K.A.5
De Geest, H.6
-
23
-
-
0021343827
-
Coronary thrombolysis with intravenously administered human tissue-type plasminogen activator produced by recombinant DNA technology
-
Van de Werf F, Bergmann SR, Fox KA, de Geest H, Hoyng CF, Sobel BE, et al: Coronary thrombolysis with intravenously administered human tissue-type plasminogen activator produced by recombinant DNA technology. Circulation 1984; 69: 605-610.
-
(1984)
Circulation
, vol.69
, pp. 605-610
-
-
Van De Werf, F.1
Bergmann, S.R.2
Fox, K.A.3
De Geest, H.4
Hoyng, C.F.5
Sobel, B.E.6
-
24
-
-
0027240597
-
An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction: The GUSTO investigators
-
An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction: The GUSTO investigators. N Engl J Med 1993; 329: 673-682.
-
(1993)
N Engl J Med
, vol.329
, pp. 673-682
-
-
-
25
-
-
0025127667
-
Clinical effects and basic studies of thrombolytic therapy on cerebral thrombosis
-
Terashi A, Kobayashi Y, Katayama Y, Inamura K, Kazama M, Abe T: Clinical effects and basic studies of thrombolytic therapy on cerebral thrombosis. Semin Thromb Hemost 1990; 16: 236-241.
-
(1990)
Semin Thromb Hemost
, vol.16
, pp. 236-241
-
-
Terashi, A.1
Kobayashi, Y.2
Katayama, Y.3
Inamura, K.4
Kazama, M.5
Abe, T.6
-
26
-
-
0026742376
-
Urgent therapy for stroke I Pilot study of tissue plasminogen activator administered within 90 min
-
Brott TG, Haley EC Jr, Levy DE, Barsan W, Broderick J, Sheppard GL, et al: Urgent therapy for stroke. I. Pilot study of tissue plasminogen activator administered within 90 min. Stroke 1992; 23: 632-640.
-
(1992)
Stroke
, vol.23
, pp. 632-640
-
-
Brott, T.G.1
Haley Jr., E.C.2
Levy, D.E.3
Barsan, W.4
Broderick, J.5
Sheppard, G.L.6
-
27
-
-
0026639662
-
Urgent therapy for stroke. II. Pilot study of tissue plasminogen activator administered 91-180 min from onset
-
Haley EC Jr, Levy DE, Brott TG, Sheppard GL, Wong MC, Kongable GL, et al: Urgent therapy for stroke. II. Pilot study of tissue plasminogen activator administered 91-180 min from onset. Stroke 1992; 23: 641-645.
-
(1992)
Stroke
, vol.23
, pp. 641-645
-
-
Haley Jr., E.C.1
Levy, D.E.2
Brott, T.G.3
Sheppard, G.L.4
Wong, M.C.5
Kongable, G.L.6
-
28
-
-
0029050323
-
Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The european cooperative acute stroke study (ecass)
-
Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al: Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 1995; 274: 1017-1025.
-
(1995)
JAMA
, vol.274
, pp. 1017-1025
-
-
Hacke, W.1
Kaste, M.2
Fieschi, C.3
Toni, D.4
Lesaffre, E.5
Von Kummer, R.6
-
29
-
-
0032541845
-
Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II)
-
Second European-Australasian Acute Stroke Study Investigators
-
Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al: Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet 1998; 352: 1245-1251.
-
(1998)
Lancet
, vol.352
, pp. 1245-1251
-
-
Hacke, W.1
Kaste, M.2
Fieschi, C.3
Von Kummer, R.4
Davalos, A.5
Meier, D.6
-
30
-
-
52649165720
-
Thrombolysis with alteplase 3 to 4.5 h after acute ischemic stroke
-
Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al: Thrombolysis with alteplase 3 to 4.5 h after acute ischemic stroke. N Engl J Med 2008; 359: 1317-1329.
-
(2008)
N Engl J Med
, vol.359
, pp. 1317-1329
-
-
Hacke, W.1
Kaste, M.2
Bluhmki, E.3
Brozman, M.4
Davalos, A.5
Guidetti, D.6
-
31
-
-
0033485522
-
Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 h after symptom onset. The Atlantis Study: A randomized controlled trial alteplase thrombolysis for acute noninterventional therapy in ischemic stroke
-
Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S: Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 h after symptom onset. The ATLANTIS Study: A randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999; 282: 2019-2026.
-
(1999)
JAMA
, vol.282
, pp. 2019-2026
-
-
Clark, W.M.1
Wissman, S.2
Albers, G.W.3
Jhamandas, J.H.4
Madden, K.P.5
Hamilton, S.6
-
32
-
-
0034120507
-
The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276 g): Results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators
-
Clark WM, Albers GW, Madden KP, Hamilton S: The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276 g): Results of a double-blind, placebo-controlled, multicenter study. Thromblytic Therapy in Acute Ischemic Stroke Study investigators. Stroke 2000; 31: 811-816.
-
(2000)
Stroke
, vol.31
, pp. 811-816
-
-
Clark, W.M.1
Albers, G.W.2
Madden, K.P.3
Hamilton, S.4
-
33
-
-
40949161352
-
Effects of alteplase beyond 3 h after stroke in the echoplanar imaging thrombolytic evaluation trial (epithet): A placebo-controlled randomised trial
-
Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al: Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial. Lancet Neurol 2008; 7: 299-309.
-
(2008)
Lancet Neurol
, vol.7
, pp. 299-309
-
-
Davis, S.M.1
Donnan, G.A.2
Parsons, M.W.3
Levi, C.4
Butcher, K.S.5
Peeters, A.6
-
34
-
-
77952112006
-
Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
-
Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, et al: Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010; 375: 1695-1703.
-
(2010)
Lancet
, vol.375
, pp. 1695-1703
-
-
Lees, K.R.1
Bluhmki, E.2
Von Kummer, R.3
Brott, T.G.4
Toni, D.5
Grotta, J.C.6
-
35
-
-
78650248913
-
Thrombolysis at 3-4.5 h after acute ischemic stroke onset y evidence from the canadian alteplase for stroke effectiveness study (cases) registry
-
Shobha N, Buchan AM, Hill MD: Thrombolysis at 3-4.5 h after acute ischemic stroke onset Y evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) registry. Cerebrovasc Dis 2011; 31: 223-228.
-
(2011)
Cerebrovasc Dis
, vol.31
, pp. 223-228
-
-
Shobha, N.1
Buchan, A.M.2
Hill, M.D.3
-
36
-
-
79951813221
-
Treating as early as possible with thrombolysis is crucial, but can we do better in the sub-4.5-hour time window?
-
Parsons MW: Treating as early as possible with thrombolysis is crucial, but can we do better in the sub-4.5-hour time window? Cerebrovasc Dis 2011; 31: 229.
-
(2011)
Cerebrovasc Dis
, vol.31
, pp. 229
-
-
Parsons, M.W.1
-
37
-
-
68749100878
-
Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: A science advisory from the American heart association/american stroke association
-
Del Zoppo GJ, Saver JL, Jauch EC, Adams HP Jr: Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: A science advisory from the American Heart Association/American Stroke Association. Stroke 2009; 40: 2945-2948.
-
(2009)
Stroke
, vol.40
, pp. 2945-2948
-
-
Del Zoppo, G.J.1
Saver, J.L.2
Jauch, E.C.3
Adams Jr., H.P.4
-
38
-
-
53249095475
-
Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): An observational study
-
Wahlgren N, Ahmed N, Davalos A, Hacke W, Millan M, Muir K, et al: Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): An observational study. Lancet 2008; 372: 1303-1309.
-
(2008)
Lancet
, vol.372
, pp. 1303-1309
-
-
Wahlgren, N.1
Ahmed, N.2
Davalos, A.3
Hacke, W.4
Millan, M.5
Muir, K.6
-
39
-
-
77955665657
-
Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: An updated analysis from SITS-ISTR
-
Ahmed N, Wahlgren N, Grond M, Hennerici M, Lees KR, Mikulik R, et al: Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: An updated analysis from SITS-ISTR. Lancet Neurol 2010; 9: 866-874.
-
(2010)
Lancet Neurol
, vol.9
, pp. 866-874
-
-
Ahmed, N.1
Wahlgren, N.2
Grond, M.3
Hennerici, M.4
Lees, K.R.5
Mikulik, R.6
-
40
-
-
78649624539
-
Thrombolysis in very elderly people: Controlled comparison of SITS international stroke thrombolysis registry and virtual international stroke trials archive
-
Mishra NK, Ahmed N, Andersen G, Egido JA, Lindsberg PJ, Ringleb PA, et al: Thrombolysis in very elderly people: Controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. Br Med J 2010; 341:c6046.
-
(2010)
Br Med J
, vol.341
-
-
Mishra, N.K.1
Ahmed, N.2
Andersen, G.3
Egido, J.A.4
Lindsberg, P.J.5
Ringleb, P.A.6
-
41
-
-
78149358574
-
Intravenous alteplase for stroke in those older than 80 years old
-
Ford GA, Ahmed N, Azevedo E, Grond M, Larrue V, Lindsberg PJ, et al: Intravenous alteplase for stroke in those older than 80 years old. Stroke 2010; 41: 2568-2574.
-
(2010)
Stroke
, vol.41
, pp. 2568-2574
-
-
Ford, G.A.1
Ahmed, N.2
Azevedo, E.3
Grond, M.4
Larrue, V.5
Lindsberg, P.J.6
-
42
-
-
79951705796
-
Comparison of outcomes following thrombolytic therapy among patients with prior stroke and diabetes in the Virtual International Stroke Trials Archive (VISTA)
-
Mishra NK, Davis SM, Kaste M, Lees KR: Comparison of outcomes following thrombolytic therapy among patients with prior stroke and diabetes in the Virtual International Stroke Trials Archive (VISTA). Diabetes Care 2010; 33: 2531-2537.
-
(2010)
Diabetes Care
, vol.33
, pp. 2531-2537
-
-
Mishra, N.K.1
Davis, S.M.2
Kaste, M.3
Lees, K.R.4
-
43
-
-
84862625338
-
The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke [the third international stroke trial (ist-3)]: A randomised controlled trial
-
Sandercock P, Wardlaw JM, Lindley RI, Dennis M, Cohen G, Murray G, et al: The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke [the Third International Stroke Trial (IST-3)]: A randomised controlled trial. Lancet 2012; 379: 2352-2363.
-
(2012)
Lancet
, vol.379
, pp. 2352-2363
-
-
Sandercock, P.1
Wardlaw, J.M.2
Lindley, R.I.3
Dennis, M.4
Cohen, G.5
Murray, G.6
-
44
-
-
77956410175
-
Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: The Japan post-marketing alteplase registration study (j-mars)
-
Nakagawara J, Minematsu K, Okada Y, Tanahashi N, Nagahiro S, Mori E, et al: Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: The Japan Post-Marketing Alteplase Registration Study (J-MARS). Stroke 2010; 41: 1984-1989.
-
(2010)
Stroke
, vol.41
, pp. 1984-1989
-
-
Nakagawara, J.1
Minematsu, K.2
Okada, Y.3
Tanahashi, N.4
Nagahiro, S.5
Mori, E.6
-
45
-
-
67449105639
-
Safety and efficacy of alteplase in the treatment of acute ischemic stroke
-
Micieli G, Marcheselli S, Tosi PA: Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag 2009; 5: 397-409.
-
(2009)
Vasc Health Risk Manag
, vol.5
, pp. 397-409
-
-
Micieli, G.1
Marcheselli, S.2
Tosi, P.A.3
-
46
-
-
84861213311
-
T-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes
-
Niego B, Freeman R, Puschmann TB, Turnley AM, Medcalf RL: T-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes. Blood 2012; 119: 4752-4761.
-
(2012)
Blood
, vol.119
, pp. 4752-4761
-
-
Niego, B.1
Freeman, R.2
Puschmann, T.B.3
Turnley, A.M.4
Medcalf, R.L.5
-
47
-
-
0035146406
-
A review of available fibrin-specific thrombolytic agents used in acute myocardial infarction
-
Tsikouris JP, Tsikouris AP: A review of available fibrin-specific thrombolytic agents used in acute myocardial infarction. Pharmacotherapy 2001; 21: 207-217.
-
(2001)
Pharmacotherapy
, vol.21
, pp. 207-217
-
-
Tsikouris, J.P.1
Tsikouris, A.P.2
-
48
-
-
79952116549
-
Reperfusion therapies for acute ischemic stroke: Current pharmacological and mechanical approaches
-
suppl)
-
Molina CA: Reperfusion therapies for acute ischemic stroke: Current pharmacological and mechanical approaches. Stroke 2011; 42(suppl):S16-S19.
-
(2011)
Stroke
, vol.42
-
-
Molina, C.A.1
-
49
-
-
79251606855
-
Advances in translational medicine 2010
-
Planas AM, Traystman RJ: Advances in translational medicine 2010. Stroke 2011; 42: 283-284.
-
(2011)
Stroke
, vol.42
, pp. 283-284
-
-
Planas, A.M.1
Traystman, R.J.2
-
50
-
-
84856609796
-
Current acute stroke trials and their potential impact on the therapeutic time window
-
Schellinger PD, Kohrmann M: Current acute stroke trials and their potential impact on the therapeutic time window. Expert Rev Neurother 2012; 12: 169-177.
-
(2012)
Expert Rev Neurother
, vol.12
, pp. 169-177
-
-
Schellinger, P.D.1
Kohrmann, M.2
-
51
-
-
0033486107
-
Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial prolyse in acute cerebral thromboembolism
-
Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al: Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. J Am Med Assoc 1999; 282: 2003-2011.
-
(1999)
J Am Med Assoc
, vol.282
, pp. 2003-2011
-
-
Furlan, A.1
Higashida, R.2
Wechsler, L.3
Gent, M.4
Rowley, H.5
Kase, C.6
-
52
-
-
84862691077
-
Plasminogen activation and thrombolysis for ischemic stroke
-
Medcalf RL, Davis SM: Plasminogen activation and thrombolysis for ischemic stroke. Int J Stroke 2012; 7: 419-425.
-
(2012)
Int J Stroke
, vol.7
, pp. 419-425
-
-
Medcalf, R.L.1
Davis, S.M.2
-
53
-
-
0028821715
-
New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA
-
Benedict CR, Refino CJ, Keyt BA, Pakala R, Paoni NF, Thomas GR, et al: New variant of human tissue plasminogen activator (TPA) with enhanced efficacy and lower incidence of bleeding compared with recombinant human TPA. Circulation 1995; 92: 3032-3040.
-
(1995)
Circulation
, vol.92
, pp. 3032-3040
-
-
Benedict, C.R.1
Refino, C.J.2
Keyt, B.A.3
Pakala, R.4
Paoni, N.F.5
Thomas, G.R.6
-
54
-
-
14844300868
-
A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke
-
Haley EC Jr, Lyden PD, Johnston KC, Hemmen TM: A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke. Stroke 2005; 36: 607-612.
-
(2005)
Stroke
, vol.36
, pp. 607-612
-
-
Haley Jr., E.C.1
Lyden, P.D.2
Johnston, K.C.3
Hemmen, T.M.4
-
55
-
-
64049096017
-
Acute ischemic stroke: Imaging-guided tenecteplase treatment in an extended time window
-
Parsons MW, Miteff F, Bateman GA, Spratt N, Loiselle A, Attia J, et al: Acute ischemic stroke: Imaging-guided tenecteplase treatment in an extended time window. Neurology 2009; 72: 915-921.
-
(2009)
Neurology
, vol.72
, pp. 915-921
-
-
Parsons, M.W.1
Miteff, F.2
Bateman, G.A.3
Spratt, N.4
Loiselle, A.5
Attia, J.6
-
56
-
-
82255192757
-
Tenecteplase for acute ischemic stroke
-
Lyden P: Tenecteplase for acute ischemic stroke. Int J Stroke 2011; 6: 509-510.
-
(2011)
Int J Stroke
, vol.6
, pp. 509-510
-
-
Lyden, P.1
-
57
-
-
84858685702
-
A randomized trial of tenecteplase versus alteplase for acute ischemic stroke
-
Parsons M, Spratt N, Bivard A, Campbell B, Chung K, Miteff F, et al: A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 2012; 366: 1099-1107.
-
(2012)
N Engl J Med
, vol.366
, pp. 1099-1107
-
-
Parsons, M.1
Spratt, N.2
Bivard, A.3
Campbell, B.4
Chung, K.5
Miteff, F.6
-
58
-
-
82955182369
-
Action anticoagulante et fibrinolytique de l'extract des glands salivaires d'une chauve-souris hématophage (Desmodus rufus)
-
Bier O: Action anticoagulante et fibrinolytique de l'extract des glands salivaires d'une chauve-souris hématophage (Desmodus rufus). C R Soc Biol (Paris) 1932; 110: 129-131.
-
(1932)
C R Soc Biol (Paris)
, vol.110
, pp. 129-131
-
-
Bier, O.1
-
59
-
-
0026077159
-
The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: Cloning and expression
-
Kratzschmar J, Haendler B, Langer G, Boidol W, Bringmann P, Alagon A, et al: The plasminogen activator family from the salivary gland of the vampire bat Desmodus rotundus: Cloning and expression. Gene 1991; 105: 229-237.
-
(1991)
Gene
, vol.105
, pp. 229-237
-
-
Kratzschmar, J.1
Haendler, B.2
Langer, G.3
Boidol, W.4
Bringmann, P.5
Alagon, A.6
-
60
-
-
80053651851
-
Desmoteplase: Discovery, insights and opportunities for ischaemic stroke
-
Medcalf RL: Desmoteplase: Discovery, insights and opportunities for ischaemic stroke. Br J Pharmacol 2012; 165: 75-89.
-
(2012)
Br J Pharmacol
, vol.165
, pp. 75-89
-
-
Medcalf, R.L.1
-
62
-
-
0028791659
-
Structural features mediating fibrin selectivity of vampire bat plasminogen activators
-
Bringmann P, Gruber D, Liese A, Toschi L, Kratzchmar J, Schleuning WD, et al: Structural features mediating fibrin selectivity of vampire bat plasminogen activators. J Biol Chem 1995; 270: 25596-25603.
-
(1995)
J Biol Chem
, vol.270
, pp. 25596-25603
-
-
Bringmann, P.1
Gruber, D.2
Liese, A.3
Toschi, L.4
Kratzchmar, J.5
Schleuning, W.D.6
-
63
-
-
33646705400
-
Dose escalation of desmoteplase for acute ischemic stroke (dedas): Evidence of safety and efficacy 3 to 9 h after stroke onset
-
Furlan AJ, Eyding D, Albers GW, Al-Rawi Y, Lees KR, Rowley HA, et al: Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): Evidence of safety and efficacy 3 to 9 h after stroke onset. Stroke 2006; 37: 1227-1231.
-
(2006)
Stroke
, vol.37
, pp. 1227-1231
-
-
Furlan, A.J.1
Eyding, D.2
Albers, G.W.3
Al-Rawi, Y.4
Lees, K.R.5
Rowley, H.A.6
-
64
-
-
19944426190
-
The desmoteplase in acute ischemic stroke trial (dias): A phase ii mri-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
-
Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, et al: The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005; 36: 66-73.
-
(2005)
Stroke
, vol.36
, pp. 66-73
-
-
Hacke, W.1
Albers, G.2
Al-Rawi, Y.3
Bogousslavsky, J.4
Davalos, A.5
Eliasziw, M.6
-
65
-
-
58249134578
-
Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): A prospective, randomised, double-blind, placebo-controlled study
-
Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al: Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): A prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol 2009; 8: 141-150.
-
(2009)
Lancet Neurol
, vol.8
, pp. 141-150
-
-
Hacke, W.1
Furlan, A.J.2
Al-Rawi, Y.3
Davalos, A.4
Fiebach, J.B.5
Gruber, F.6
-
66
-
-
84861580849
-
Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase
-
Fiebach JB, Al-Rawi Y, Wintermark M, Furlan AJ, Rowley HA, Lindsten A, et al: Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase. Stroke 2012; 43: 1561-1566.
-
(2012)
Stroke
, vol.43
, pp. 1561-1566
-
-
Fiebach, J.B.1
Al-Rawi, Y.2
Wintermark, M.3
Furlan, A.J.4
Rowley, H.A.5
Lindsten, A.6
-
67
-
-
84866485863
-
The desmoteplase in acute ischemic stroke (dias) clinical trial program
-
Von Kummer R, Albers GW, Mori E: The Desmoteplase in Acute Ischemic Stroke (DIAS) clinical trial program. Int J Stroke 2012; 7: 589-596.
-
(2012)
Int J Stroke
, vol.7
, pp. 589-596
-
-
Von Kummer, R.1
Albers, G.W.2
Mori, E.3
-
68
-
-
33644874026
-
Time is brain Y quantified
-
Saver JL. Time is brain Y quantified. Stroke 2006; 37: 263-266.
-
(2006)
Stroke
, vol.37
, pp. 263-266
-
-
Saver, J.L.1
-
69
-
-
0037224785
-
Diagnostic accuracy of stroke referrals from primary care, emergency room physicians, and ambulance staff using the face arm speech test
-
Harbison J, Hossain O, Jenkinson D, Davis J, Louw SJ, Ford GA: Diagnostic accuracy of stroke referrals from primary care, emergency room physicians, and ambulance staff using the face arm speech test. Stroke 2003; 34: 71-76.
-
(2003)
Stroke
, vol.34
, pp. 71-76
-
-
Harbison, J.1
Hossain, O.2
Jenkinson, D.3
Davis, J.4
Louw, S.J.5
Ford, G.A.6
-
70
-
-
77954174189
-
The 'golden hour' and acute brain ischemia: Presenting features and lytic therapy in >30,000 patients arriving within 60 min of stroke onset
-
Saver JL, Smith EE, Fonarow GC, Reeves MJ, Zhao X, Olson DM, et al: The 'golden hour' and acute brain ischemia: Presenting features and lytic therapy in >30,000 patients arriving within 60 min of stroke onset. Stroke 2010; 41: 1431-1439.
-
(2010)
Stroke
, vol.41
, pp. 1431-1439
-
-
Saver, J.L.1
Smith, E.E.2
Fonarow, G.C.3
Reeves, M.J.4
Zhao, X.5
Olson, D.M.6
-
71
-
-
79960101157
-
How to make better use of thrombolytic therapy in acute ischemic stroke
-
Donnan GA, Davis SM, Parsons MW, Ma H, Dewey HM, Howells DW: How to make better use of thrombolytic therapy in acute ischemic stroke. Nat Rev Neurol 2011; 7: 400-409.
-
(2011)
Nat Rev Neurol
, vol.7
, pp. 400-409
-
-
Donnan, G.A.1
Davis, S.M.2
Parsons, M.W.3
Ma, H.4
Dewey, H.M.5
Howells, D.W.6
-
72
-
-
84867879470
-
Reducing inhospital delay to 20 min in stroke thrombolysis
-
Meretoja A, Strbian D, Mustanoja S, Tatlisumak T, Lindsberg PJ, Kaste M: Reducing inhospital delay to 20 min in stroke thrombolysis. Neurology 2012; 79: 306-313.
-
(2012)
Neurology
, vol.79
, pp. 306-313
-
-
Meretoja, A.1
Strbian, D.2
Mustanoja, S.3
Tatlisumak, T.4
Lindsberg, P.J.5
Kaste, M.6
-
73
-
-
0028892679
-
Treatment of acute ischemic stroke Challenging the concept of a rigid and universal time window
-
Baron JC, von Kummer R, del Zoppo GJ: Treatment of acute ischemic stroke. Challenging the concept of a rigid and universal time window. Stroke 1995; 26: 2219-2221.
-
(1995)
Stroke
, vol.26
, pp. 2219-2221
-
-
Baron, J.C.1
Von Kummer, R.2
Del Zoppo, G.J.3
-
74
-
-
0036791848
-
Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 h
-
Rother J, Schellinger PD, Gass A, Siebler M, Villringer A, Fiebach JB, et al: Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 h. Stroke 2002; 33: 2438-2445.
-
(2002)
Stroke
, vol.33
, pp. 2438-2445
-
-
Rother, J.1
Schellinger, P.D.2
Gass, A.3
Siebler, M.4
Villringer, A.5
Fiebach, J.B.6
-
75
-
-
33746987483
-
Imaging of acute stroke
-
Muir KW, Buchan A, von Kummer R, Rother J, Baron JC: Imaging of acute stroke. Lancet Neurol 2006; 5: 755-768.
-
(2006)
Lancet Neurol
, vol.5
, pp. 755-768
-
-
Muir, K.W.1
Buchan, A.2
Von Kummer, R.3
Rother, J.4
Baron, J.C.5
-
76
-
-
84855358189
-
Mechanical thrombolysis and stenting in acute ischemic stroke
-
Gralla J, Brekenfeld C, Mordasini P, Schroth G: Mechanical thrombolysis and stenting in acute ischemic stroke. Stroke 2012; 43: 280-285.
-
(2012)
Stroke
, vol.43
, pp. 280-285
-
-
Gralla, J.1
Brekenfeld, C.2
Mordasini, P.3
Schroth, G.4
-
77
-
-
84867072741
-
Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): A randomised, parallel-group, non-inferiority trial
-
Saver JL, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, et al: Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): A randomised, parallel-group, non-inferiority trial. Lancet 2012; 380: 1241-1249.
-
(2012)
Lancet
, vol.380
, pp. 1241-1249
-
-
Saver, J.L.1
Jahan, R.2
Levy, E.I.3
Jovin, T.G.4
Baxter, B.5
Nogueira, R.G.6
-
78
-
-
33845298309
-
Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study
-
Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al: Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006; 60: 508-517.
-
(2006)
Ann Neurol
, vol.60
, pp. 508-517
-
-
Albers, G.W.1
Thijs, V.N.2
Wechsler, L.3
Kemp, S.4
Schlaug, G.5
Skalabrin, E.6
-
79
-
-
77956258035
-
Where are we now with intravenous thrombolysis for acute ischaemic stroke?
-
Sandercock P, Wardlaw J, Lindley R: Where are we now with intravenous thrombolysis for acute ischaemic stroke? Int J Stroke 2010; 5: 381-382.
-
(2010)
Int J Stroke
, vol.5
, pp. 381-382
-
-
Sandercock, P.1
Wardlaw, J.2
Lindley, R.3
-
80
-
-
60549111231
-
Imaging-based thrombolysis trial in acute ischemic stroke-II (ITAIS-II)
-
Wang Y, Liao X, Zhao X, Wang C, Liu L, Zhou Y, et al: Imaging-based thrombolysis trial in acute ischemic stroke-II (ITAIS-II). Int J Stroke 2009; 4: 49-53.
-
(2009)
Int J Stroke
, vol.4
, pp. 49-53
-
-
Wang, Y.1
Liao, X.2
Zhao, X.3
Wang, C.4
Liu, L.5
Zhou, Y.6
-
81
-
-
84155184488
-
A multicentre, randomized, double-blinded, placebocontrolled phase iii study to investigate extending the time for thrombolysis in emergency neurological deficits (extend)
-
Ma H, Parsons MW, Christensen S, Campbell BC, Churilov L, Connelly A, et al: A multicentre, randomized, double-blinded, placebocontrolled phase III study to investigate Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND). Int J Stroke 2012; 7: 74-80.
-
(2012)
Int J Stroke
, vol.7
, pp. 74-80
-
-
Ma, H.1
Parsons, M.W.2
Christensen, S.3
Campbell, B.C.4
Churilov, L.5
Connelly, A.6
-
82
-
-
84862629039
-
Recombinant tissue plasminogen activator for acute ischaemic stroke: An updated systematic review and meta-analysis
-
Wardlaw JM, Murray V, Berge E, del Zoppo G, Sandercock P, Lindley RL, et al: Recombinant tissue plasminogen activator for acute ischaemic stroke: An updated systematic review and meta-analysis. Lancet 2012; 379: 2364-2372.
-
(2012)
Lancet
, vol.379
, pp. 2364-2372
-
-
Wardlaw, J.M.1
Murray, V.2
Berge, E.3
Del Zoppo, G.4
Sandercock, P.5
Lindley, R.L.6
|