On the efficiency of two-stage response-adaptive designs

Statistics in Medicine

Volumn 32, Issue 10, 2013, Pages 1646-1660

  Dette, Holger ^a   Bornkamp, Björn ^b   Bretz, Frank ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Dose estimation; Dose finding; Maximum likelihood estimation; Mean squared error; Non linear regression; Optimal design

Indexed keywords

ARTICLE; CALCULATION; DATA ANALYSIS; LOGISTIC REGRESSION ANALYSIS; MATHEMATICAL MODEL; NONLINEAR REGRESSION ANALYSIS; POISSON DISTRIBUTION; SAMPLE SIZE; SIMULATION; STATISTICAL ANALYSIS; STUDY DESIGN; VARIANCE;

ANTI-ANXIETY AGENTS; BIOSTATISTICS; CLINICAL TRIALS AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIKELIHOOD FUNCTIONS; LOGISTIC MODELS; MODELS, STATISTICAL; NONLINEAR DYNAMICS; POISSON DISTRIBUTION; SAMPLE SIZE;

EID: 84876447948     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5555     Document Type: Article

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