Design and analysis of dose-finding studies combining multiple comparisons and modeling procedures

Journal of Biopharmaceutical Statistics

Volumn 16, Issue 5, 2006, Pages 639-656

  Pinheiro, José ^a   Bornkamp, Björn ^b   Bretz, Frank ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

Contrast test; Dose ranging; Minimum effective dose; Multiple testing; Phase II trials; Power and sample size calculation; Sensitivity analysis

Indexed keywords

ANXIOLYTIC AGENT;

ANXIETY DISORDER; ARTICLE; CALCULATION; CLINICAL TRIAL; COMPARATIVE STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG EFFICACY; DRUG RESEARCH; HUMAN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SAMPLE SIZE; SENSITIVITY ANALYSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE;

ALGORITHMS; ANTI-ANXIETY AGENTS; ANXIETY DISORDERS; CLINICAL TRIALS, PHASE II; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, STATISTICAL; RESEARCH DESIGN; SAMPLE SIZE; TREATMENT OUTCOME;

EID: 33751567567     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543400600860428     Document Type: Article

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