Chronic Treatment with the AMP-Kinase Activator AICAR Increases Glycogen Storage and Fatty Acid Oxidation in Skeletal Muscles but Does Not Reduce Hyperglucagonemia and Hyperglycemia in Insulin Deficient Rats

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Vitzel, Kaio F ^a,b   Bikopoulos, George ^a   Hung, Steven ^a   Pistor, Kathryn E ^a   Patterson, Jessica D ^a   Curi, Rui ^b   Ceddia, Rolando B ^a  

^a YORK UNIVERSITY   (Canada)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENYLATE KINASE; FATTY ACID; GLUCAGON; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3; INSULIN; PALMITIC ACID; PROTEIN KINASE B; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; EPITROCHLEARIS MUSCLE; EXTENSOR DIGITORUM LONGUS MUSCLE; FAT MASS; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLYCEMIC CONTROL; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HYPERGLUCAGONEMIA; HYPERGLYCEMIA; IN VIVO STUDY; INSULIN DEFICIENCY; INSULINEMIA; LONG TERM CARE; MALE; MOUSE; MUSCLE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; SOLEUS MUSCLE;

ADENYLATE KINASE; ADIPOSITY; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; BLOOD GLUCOSE; EPIDIDYMIS; FATTY ACIDS; GLUCAGON; GLYCOGEN; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; HYPERGLYCEMIA; INSULIN; MALE; MUSCLE, SKELETAL; OXIDATION-REDUCTION; PALMITATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RIBONUCLEOTIDES; TRIGLYCERIDES;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84876445821     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062190     Document Type: Article

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