Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity

Indian Journal of Medical Research

Volumn 137, Issue 3, 2013, Pages 540-548

  Nutan, ^a   Modi, Manoj ^a   Goelb, Tanvi ^b   Das, Tiyasa ^a   Malik, Shweta ^a   Suri, Samiksha ^b   Singh Rawat, Ajay Kumar ^b   Srivastava, Sharad Kumar ^b   Tuli, Rakesh ^c   Malhotra, Swadesh ^b   Gupta, Satish Kumar ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

^c NATIONAL AGRI FOOD BIOTECHNOLOGY INSTITUTE   (India)

Author keywords

Anti HIV 1 activity; Ellagic acid; Gallic acid; Lagerstroemia speciosa L; Protease; Reverse transcriptase; Rutin

Indexed keywords

ELLAGIC ACID; GALLIC ACID; GREEN FLUORESCENT PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; LAGERSTROEMIA EXTRACT; PLANT EXTRACT; RNA DIRECTED DNA POLYMERASE; RUTOSIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IC 50; LAGERSTROEMIA; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT LEAF; PLANT STEM; PROTEIN EXPRESSION; VIRUS LOAD;

CELL LINE; ELLAGIC ACID; ENZYME INHIBITORS; GALLIC ACID; HIV INFECTIONS; HIV PROTEASE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; LAGERSTROEMIA; PLANT EXTRACTS;

EID: 84876441899     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, et al. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 1984; 312: 767-8.
2. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272: 1955-8.
3. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272: 872-7.
4. Flexner C. HIV drug development: the next 25 years. Nat Rev Drug Disco 2007; 6: 959-66.
5. O'Brien WA. Resistance against reverse transcriptase inhibitors. Clin Infect Dis 2000; 30 (Suppl 2): S185-92.
6. Hupfeld J, Efferth T. Drug resistance of human immunodeficiency virus and overcoming it by natural products. In Vivo 2009; 23: 1-6.
7. el-Mekkawy S, Meselhy MR, Kusumoto IT, Kadota S, Hattori M, Namba T. Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. Chem Pharm Bull (Tokyo) 1995; 43: 641-8.
8. Matthee G, Wright AD, Konig GM. HIV reverse transcriptase inhibitors of natural origin. Planta Med 1999; 65: 493-506.
9. Filho JR, de Sousa Falcao H, Batista LM, Filho JM, Piuvezam MR. Effects of plant extracts on HIV-1 protease. Curr HIV Res 2010; 8: 531-44.
10. Garcia F. On the hypoglycemic effect of decoction of Lagerstroemia speciosa (banaba) administered orally. J Phil Med Assoc 1940; 20: 395-402.
11. Quisumbing E. Medicinal plants of the Philippines. Quezon, Philippines: Katha Publishing; 1978. p. 640-2.
12. Matsuyama F. Composition for inhibiting increase in blood sugar level or lowering blood sugar level. United States Patent Application No. 09/730, 2008; 74.
13. Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KKAY mice. Biosci Biotechnol Biochem 1996; 60: 204-8.
14. Liu F, Kim J, Li Y, Liu X, Li J, Chen X. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptakestimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr 2001; 131: 2242-7.
15. Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo) 1999; 45: 791-5.
16. Murakami C, Myoga K, Kasai R, Ohtani K, Kurokawa T, Ishibashi S, et al. Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. Chem Pharm Bull (Tokyo) 1993; 41: 2129-31.
17. Hayashi T, Maruyama H, Kasai R, Hattori K, Takasuga S, Hazeki O, et al. Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells. Planta Med 2002; 68: 173-5.
18. Judy WV, Hari SP, Stogsdilla WW, Judy JS, Naguib YMA, Passwater R. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in type II diabetics. A dose-dependence study. J Ethnopharmacol 2003; 87: 115-7.
19. Singh B, Singh HB, Singh A, Singh B, Mishra A, Nautiyal C. Lagerstroemia speciosa fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Pseudomonas aeruginosa. Microbiology 2012; 158: 529-38.
20. Choi HJ, Bae EY, Song JH, Baek SH, Kwon DH. Inhibitory effects of orobol 7-O-D-glucoside from banaba (Lagerstroemia speciosa L.) on human rhinoviruses replication. Lett Appl Microbiol 2010; 51: 1-5.
21. Mahajan A, Pai N. Simultaneous isolation and identification of phytoconstituents from Terminalia chebula by preparative chromatograph. J Chem Pharm Res 2010; 2: 97-103.
22. Gervaix A, West D, Leoni LM, Richman DD, Wong-Staal F, Corbeil J. A new reporter cell line to monitor HIV infection and drug susceptibility in vitro. Proc Natl Acad Sci USA 1997; 94: 4653-8.
23. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 1993; 90: 8392-6.
24. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
25. Kumar M, Mitra D. Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef-mediated enhancement of viral gene expression and replication. J Biol Chem 2005; 280: 40041-50.
26. Stohs SJ, Miller H, Kaats GR. A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res 2012; 26: 317-24.
27. Farnet CM, Wang B, Hansen M, Lipford JR, Zalkow L, Robinson WE Jr, et al. Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism. Antimicrob Agents Chemother 1998; 42: 2245-53.
28. Tuchinda P, Kornsakulkarn J, Pohmakotr M, Kongsaeree P, Prabpai S, Yoosook C, et al. Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima. J Nat Prod 2008; 71: 655-63.
29. Bedoya LM, Abad MJ, Sanchez-Palomino S, Alcami J, Bermejo P. Ellagitannins from Tuberaria lignosa as entry inhibitors of HIV. Phytomedicine 2010; 17: 69-74.
30. Houghton PJ. Compounds with anti-HIV activity from plants. Trans R Soc Trop Med Hyg 1996; 90: 601-4.
31. Talwar GP, Dar SA, Rai MK, Reddy KV, Mitra D, Kulkarni SV, et al. A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. Int J Antimicrob Agents 2008; 32: 180-5.
32. Usha PR, Naidu MU, Raju YS. Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection. Drugs R D 2003; 4: 103-9.