Luteolin is a rare substrate of human catechol-O-methyltransferase favoring a para-methylation

Molecular Nutrition and Food Research

Volumn 57, Issue 5, 2013, Pages 877-885

  Chen, Zhong Jian ^a,b   Dai, Yan Qing ^a   Kong, Si Si ^a   Song, Fei Feng ^a   Li, Li Ping ^a   Ye, Jian Feng ^c   Wang, Ru Wei ^c   Zeng, Su ^a   Zhou, Hui ^a   Jiang, Hui Di ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG CANCER HOSPITAL   (China)

^c Zhejiang CONBA Pharmaceutical Co Ltd   (China)

Author keywords

Catechol O methyltransferase (COMT); Demethylation; Luteolin; Methylation; Regioselectivity

Indexed keywords

CATECHOL METHYLTRANSFERASE; CYP1A2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYP3A5 PROTEIN, HUMAN; CYTOCHROME P450 1A2; CYTOCHROME P450 3A; LUTEOLIN; RECOMBINANT PROTEIN;

ADULT; ARTICLE; FEMALE; HUMAN; LIVER; LIVER MICROSOME; MALE; METABOLISM; METHYLATION; ORAL DRUG ADMINISTRATION; URINE;

ADMINISTRATION, ORAL; ADULT; CATECHOL O-METHYLTRANSFERASE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; FEMALE; HUMANS; LIVER; LUTEOLIN; MALE; METHYLATION; MICROSOMES, LIVER; RECOMBINANT PROTEINS;

EID: 84876422449     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200584     Document Type: Article

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