Regioselectivity of catechol O-methyltransferase confers enhancement of catalytic activity

Chemical Physics Letters

Volumn 506, Issue 4-6, 2011, Pages 135-138

  Tsao, Douglas ^a   Liu, Shubin ^b   Dokholyan, Nikolay V ^c  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC ACTIVITY; GASPHASE; HYDROPHOBIC AMINO ACIDS; HYDROXYL GROUPS; O-METHYLTRANSFERASE; REACTION BARRIERS; SEQUENCE ANALYSIS;

AMINO ACIDS; CATALYST ACTIVITY; PHENOLS;

REGIOSELECTIVITY;

EID: 79954617286     PISSN: 00092614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cplett.2011.03.048     Document Type: Article

References (10)

1. P.T. Mannisto, and S. Kaakkola Pharmacol. Rev. 51 1999 593
2. M.S. Masri, D.J. Robbins, O.H. Emerson, and F. Deeds Nature 202 1964 878
3. Y. Zheng, and T.C. Bruice J. Am. Chem. Soc. 119 1997 8137
4. B. Kuhn, and P.A. Kollman J. Am. Chem. Soc. 122 2000 2586
5. M. Roca, S. Marti, J. Andres, V. Moliner, I. Tunon, J. Bertran, and I.H. Williams J. Am. Chem. Soc. 125 2003 7726
6. T. Lotta, J. Vidgren, C. Tilgmann, I. Ulmanen, K. Melen, I. Julkunen, and J. Taskinen Biochemistry 34 1995 4202
7. G.A. Papoian, W.F. DeGrado, and M.L. Klein J. Am. Chem. Soc. 125 2003 560
8. K. Rutherford, I. Le Trong, R.E. Stenkamp, and W.W. Parson J. Mol. Biol. 380 2008 120
9. S. Liu Acta Phys. Chim. Sin. 25 2009 590
10. S. Liu, H. Hu, and L.G. Pedersen J. Phys. Chem. A 114 2010 5913