Sulfur-containing angiotensin-converting enzyme inhibitor 3-thienylalanine-ornithyl-proline activates endothelial function and expression of genes involved in renin-angiotensin system

Journal of Cardiovascular Pharmacology

Volumn 61, Issue 4, 2013, Pages 311-317

  Chaudhary, Snehlata ^a,b   Seth, Mahesh Kumar ^a,c   Vats, Ishwar Dutt ^a   Kumar, Krishan ^a   Biswas, Parbati ^b   Karar, Jayashree ^a   Hussain, M Ejaz ^c   Pasha, M A Q ^a   Pasha, Santosh ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

^c JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

Author keywords

ACE inhibitors; gene expression; nitric oxide; peptidomimic; thiophene ring

Indexed keywords

3 THIENYLALANINE ORNITHYL PROLINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN II; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; ORNITHINE DERIVATIVE; PROTEIN P22; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; GENE EXPRESSION REGULATION; HYPERTENSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASOCONSTRICTION; VASODILATATION; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIOXIDANTS; AORTA; CAPTOPRIL; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; HYPERTENSION; MALE; NITRIC OXIDE; OLIGOPEPTIDES; OXIDATIVE STRESS; RATS; RATS, INBRED SHR; RATS, WISTAR; RENIN-ANGIOTENSIN SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIOPHENES; UP-REGULATION; VASODILATION;

EID: 84876416520     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318280e16e     Document Type: Article

References (31)

1. Griendling KK, Minieri CA, Ollerenshaw JD, et al. Ang II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994;74:1141-1148
2. Schnackenberg CG, Wilcox CS. Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin F2alpha. Hypertension. 1999;33:424-428
3. Vaziri ND, Wang XQ, Oveisi F, et al. Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats. Hypertension. 2000;36:142-146
4. Loiola RA, Reis FCG, Kawamoto EM, et al. Role of vascular kinin B1 and B2 receptor in endothelial nitric oxide metabolism. Peptides 2011; 32:1700-1705
5. Pasini AF, Garbin U, NavaMC, et al. Effect of sulfhydryl and non-sulfhydryl angiotensin-converting enzyme inhibitors on endothelial function in essential hypertensive patients. Am J Hypertens. 2007;20:443-450
6. Patchett AA. The chemistry of enalapril. Br J Clin Pharmacol. 1984;18: 201S-207S
7. Pavar MC, Hanif K, Azam A, et al. Structure-activity relationship study between ornithyl-proline and lysyl-proline based tripeptidomimics as angiotensin converting enzyme inhibitors. Bioorg Med Chem Lett. 2006;16:2117-2121
8. Hanif K, Chaudhary S, Pavar MC, Arif E, Fahim M, Pasha MAQ, Pasha S. Effect of 3-thienylalanine-ornithine-proline, new sulfur-containing angiotensin- converting enzyme inhibitor on blood pressure and oxidative stress in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 2009;53: 145-150
9. Sweles JD, Sever PS, Peart WS. Mechanism of Blood Pressure Control. Clinical Atlas of Hypertension. New York: Gower Medical Publisher; 1991
10. Peach MJ. Renin-angiotensin system: Biochemistry and mechanisms of action. Physiol Rev. 1977;57:313-370
11. Vercruysse L, Morel N, Camp JV, et al. Antihypertensive mechanism of the dipeptide Val-Tyr in rat aorta. Peptides. 2008;29:261-267
12. Parik T, Allikmets K, Teesalu R, et al. Evidence for oxidative stress in essential hypertension: Perspective for antioxidant therapy. J Cardiovasc Risk. 1996;3:49-54
13. Ward NC, Croft KD. Hypertension and oxidative stress. Clin Exp Pharmacol Physiol. 2006;33:872-876
14. Fleming I, Michaelis UR, Bredenkotter D, et al. Endothelium-derived hyperpolarizing factor synthase (cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res. 2001;88:44-51
15. Sarkis A, Roman RJ. Role of cytochrome P450 metabolites of arachidonic acid in hypertension. Curr Drug Metab. 2004;5:245-256
16. El-Hilaly J, Lyoussi B, Wibo M, et al. Vasorelaxant effect of the aqueous extract of Ajugaiva in rat aorta. J Ethnopharmacol. 2004;93:69-74
17. FitzGerald RJ, Murray B, Walsch DJ. Hypotensive peptides from milk proteins. J Nutr. 2004;134:980S-988S
18. Lee HW, Lakshminarayanan S, Rangaiah GP. Models and simple controllers for blood pressure regulation in post cardiac surgery patients. J Inst Eng. 2005;45:14-26
19. Sved AF, Schreihofer AM, Kost CK. Blood pressure regulation in baroreceptor denervated rats. Clin Exp Pharmacol Physiol. 1996;24:77-82
20. Spielman WS, Davis JO. The renin-angiotensin system and aldosterone secretion during sodium depletion in the rat. Cir Res. 1974;35:615-624
21. Gewaltig MT, Kojda G. Vasoprotection by nitric oxide: Mechanisms and therapeutic potential. Cardiovasc Res. 2002;55:250-260
22. Hamilton CA, Miller WH, Al-Benna S, et al. Strategies to reduce oxidative stress in cardiovascular disease. Clin Sci. 2004;106:219-234
23. Török J. Participation of nitric oxide in different models of experimental hypertension. Physiol Res. 2008;57:813-825
24. Shimokawa H, Yasutake H, Fujii K, et al. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endotheliumdependent relaxations in rat mesenteric circulation. J Cardiovasc Pharmacol. 1996;28:703-711
25. Romero JC, Reckelhoff JF. Role of angiotensin and oxidative stress in essential hypertension. Hypertension. 1999;34:943-949
26. Raij L. Nitric oxide in hypertension: Relationship with renal injury and left ventricular hypertrophy. Hypertension. 1998;31:189-193
27. McIntyre M, Bohr DF, Dominiczak AF. Endothelial function in hypertension: The role of superoxide anion. Hypertension. 1999;34:539-545
28. Guzik TJ, West NE, Black E, et al. Vascular superoxide production by NADPH oxidase: Association with endothelial dysfunction and clinical risk factors. Circ Res. 2000;86:85-90
29. Paolo P, Giovanni MP, Cravero E, et al. The molecular sources of reactive oxygen species in hypertension. Blood Press. 2008;17:70-77
30. PryorWA, Squadrito GL. The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol. 1995;268:L699-L722
31. Pechanova O, Simko F. The role of nitric oxide in the maintenance of vasoactive balance. Physiol Res. 2007;56:S7-S16