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Volumn 27, Issue 6, 2013, Pages 981-989

Have the explosive HIV epidemics in sub-Saharan Africa been driven by higher community viral load?

Author keywords

Co infection; Epidemic; HIV; Mathematical model; Sub Saharan Africa; Viral load

Indexed keywords

VIRUS RNA;

EID: 84876414426     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835cb927     Document Type: Article
Times cited : (21)

References (38)
  • 1
    • 84861694769 scopus 로고    scopus 로고
    • available at, [Accessed 3 January 2012]
    • UNAIDS. UNAIDS 2011 World AIDS Day Report (available at) http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/ 2011/JC2216-WorldAIDSday-report-2011-en.pdf [Accessed 3 January 2012]. 2011.
    • (2011) UNAIDS 2011 World AIDS Day Report
  • 2
    • 80052018392 scopus 로고    scopus 로고
    • A tale of two countries: Rethinking sexual risk for HIV among young people in South Africa and the United States
    • Pettifor AE, Levandowski BA, Macphail C, Miller WC, Tabor J, Ford C, et al. A tale of two countries: rethinking sexual risk for HIV among young people in South Africa and the United States. J Adolesc Health 2011; 49:237e231-243e231.
    • (2011) J Adolesc Health , vol.49
    • Pettifor, A.E.1    Levandowski, B.A.2    Macphail, C.3    Miller, W.C.4    Tabor, J.5    Ford, C.6
  • 3
    • 0031297433 scopus 로고    scopus 로고
    • Sexual networks and HIV
    • Morris M. Sexual networks and HIV. AIDS 1997; 11:S209- S216.
    • (1997) AIDS , vol.11
    • Morris, M.1
  • 4
    • 33845386531 scopus 로고    scopus 로고
    • Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa
    • Abu-Raddad LJ, Patnaik P, Kublin JG. Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa. Science 2006; 314:1603-1606.
    • (2006) Science , vol.314 , pp. 1603-1606
    • Abu-Raddad, L.J.1    Patnaik, P.2    Kublin, J.G.3
  • 5
    • 79551616146 scopus 로고    scopus 로고
    • Biological factors that may contribute to regional and racial disparities in HIV prevalence
    • Kaul R, Cohen CR, Chege D, Yi TJ, Tharao W, McKinnon LR, et al. Biological factors that may contribute to regional and racial disparities in HIV prevalence. Am J Reprod Immunol 2011; 65:317-324.
    • (2011) Am J Reprod Immunol , vol.65 , pp. 317-324
    • Kaul, R.1    Cohen, C.R.2    Chege, D.3    Yi, T.J.4    Tharao, W.5    McKinnon, L.R.6
  • 6
    • 0034826484 scopus 로고    scopus 로고
    • Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa
    • Fideli US, Allen SA, Musonda R, Trask S, Hahn BH, Weiss H, et al. Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa. AIDS Res Hum Retroviruses 2001; 17:901- 910.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 901-910
    • Fideli, U.S.1    Allen, S.A.2    Musonda, R.3    Trask, S.4    Hahn, B.H.5    Weiss, H.6
  • 7
    • 0035857959 scopus 로고    scopus 로고
    • Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda
    • Gray RH, Wawer MJ, Brookmeyer R, Sewankambo NK, Serwadda D, Wabwire-Mangen F, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001; 357:1149-1153.
    • (2001) Lancet , vol.357 , pp. 1149-1153
    • Gray, R.H.1    Wawer, M.J.2    Brookmeyer, R.3    Sewankambo, N.K.4    Serwadda, D.5    Wabwire-Mangen, F.6
  • 9
    • 77956057163 scopus 로고    scopus 로고
    • Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco
    • Das M, Chu PL, Santos GM, Scheer S, Vittinghoff E, McFarland W, et al. Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PLoS One 2010; 5:e11068.
    • (2010) PLoS One , vol.5
    • Das, M.1    Chu, P.L.2    Santos, G.M.3    Scheer, S.4    Vittinghoff, E.5    McFarland, W.6
  • 11
    • 77958524767 scopus 로고    scopus 로고
    • Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk
    • Lingappa JR, Hughes JP, Wang RS, Baeten JM, Celum C, Gray GE, et al. Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk. PLoS One 2010; 5:e12598.
    • (2010) PLoS One , vol.5
    • Lingappa, J.R.1    Hughes, J.P.2    Wang, R.S.3    Baeten, J.M.4    Celum, C.5    Gray, G.E.6
  • 13
    • 75449125513 scopus 로고
    • A longitudinal survey of natural malaria infection in a group of west african adults
    • Bruce-Chwatt LJ. A Longitudinal Survey of Natural Malaria Infection in a Group of West African Adults. West Afr Med J 1963; 12:199-217.
    • (1963) West Afr Med J , vol.12 , pp. 199-217
    • Bruce-Chwatt, L.J.1
  • 14
    • 0032938276 scopus 로고    scopus 로고
    • Plasmodium falciparum clinical malaria in Dielmo, a holoendemic area in Senegal: No influence of acquired immunity on initial symptomatology and severity of malaria attacks
    • Rogier C, Ly AB, Tall A, Cisse B, Trape JF. Plasmodium falciparum clinical malaria in Dielmo, a holoendemic area in Senegal: no influence of acquired immunity on initial symptomatology and severity of malaria attacks. Am J Trop Med Hyg 1999; 60:410-420.
    • (1999) Am J Trop Med Hyg , vol.60 , pp. 410-420
    • Rogier, C.1    Ly, A.B.2    Tall, A.3    Cisse, B.4    Trape, J.F.5
  • 16
    • 12344266741 scopus 로고    scopus 로고
    • Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: A prospective cohort study
    • Kublin JG, Patnaik P, Jere CS, Miller WC, Hoffman IF, Chimbiya N, et al. Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: A prospective cohort study. Lancet 2005; 365:233-240.
    • (2005) Lancet , vol.365 , pp. 233-240
    • Kublin, J.G.1    Patnaik, P.2    Jere, C.S.3    Miller, W.C.4    Hoffman, I.F.5    Chimbiya, N.6
  • 17
    • 54749135281 scopus 로고    scopus 로고
    • Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    • Mark KE, Wald A, Magaret AS, Selke S, Olin L, Huang ML, et al. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J Infect Dis 2008; 198:1141-1149.
    • (2008) J Infect Dis , vol.198 , pp. 1141-1149
    • Mark, K.E.1    Wald, A.2    Magaret, A.S.3    Selke, S.4    Olin, L.5    Huang, M.L.6
  • 18
    • 48449099125 scopus 로고    scopus 로고
    • Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa
    • Abu-Raddad LJ, Magaret AS, Celum C, Wald A, Longini IM Jr, Self SG, et al. Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS ONE 2008; 3:e2230.
    • (2008) PLoS ONE , vol.3
    • Abu-Raddad, L.J.1    Magaret, A.S.2    Celum, C.3    Wald, A.4    Longini Jr., I.M.5    Self, S.G.6
  • 19
    • 3042664676 scopus 로고    scopus 로고
    • The natural history of HIV-1 and HIV-2 infections in adults in Africa: A literature review
    • Jaffar S, Grant AD, Whitworth J, Smith PG, Whittle H. The natural history of HIV-1 and HIV-2 infections in adults in Africa: A literature review. Bull World Health Organ 2004; 82:462-469.
    • (2004) Bull World Health Organ , vol.82 , pp. 462-469
    • Jaffar, S.1    Grant, A.D.2    Whitworth, J.3    Smith, P.G.4    Whittle, H.5
  • 20
    • 0037176453 scopus 로고    scopus 로고
    • Progression to symptomatic disease in people infected with HIV-1 in rural Uganda: Prospective cohort study
    • Morgan D, Mahe C, Mayanja B, Whitworth JA. Progression to symptomatic disease in people infected with HIV-1 in rural Uganda: prospective cohort study. BMJ 2002; 324:193-196.
    • (2002) BMJ , vol.324 , pp. 193-196
    • Morgan, D.1    Mahe, C.2    Mayanja, B.3    Whitworth, J.A.4
  • 21
    • 15044338866 scopus 로고    scopus 로고
    • The global distribution of clinical episodes of plasmodium falciparum malaria
    • Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005; 434:214-217.
    • (2005) Nature , vol.434 , pp. 214-217
    • Snow, R.W.1    Guerra, C.A.2    Noor, A.M.3    Myint, H.Y.4    Hay, S.I.5
  • 23
    • 80051791963 scopus 로고    scopus 로고
    • The role of coinfections in HIV epidemic trajectory and positive prevention: A systematic review and meta-analysis
    • Barnabas RV, Webb EL, Weiss HA, Wasserheit JN. The role of coinfections in HIV epidemic trajectory and positive prevention: A systematic review and meta-analysis. AIDS 2011; 25:1559-1573.
    • (2011) AIDS , vol.25 , pp. 1559-1573
    • Barnabas, R.V.1    Webb, E.L.2    Weiss, H.A.3    Wasserheit, J.N.4
  • 24
    • 10344244491 scopus 로고    scopus 로고
    • Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals
    • Rizzardini G, Piconi S, Ruzzante S, Fusi ML, Lukwiya M, Declich S, et al. Immunological activation markers in the serum of African and European HIV-seropositive and seronegative individuals. AIDS 1996; 10:1535-1542.
    • (1996) AIDS , vol.10 , pp. 1535-1542
    • Rizzardini, G.1    Piconi, S.2    Ruzzante, S.3    Fusi, M.L.4    Lukwiya, M.5    Declich, S.6
  • 25
    • 0033249450 scopus 로고    scopus 로고
    • Increased CCR5 expression with decreased beta chemokine secretion in Ethiopians: Relevance to AIDS in Africa
    • Kalinkovich A, Weisman Z, Leng Q, Borkow G, Stein M, Greenberg Z, et al. Increased CCR5 expression with decreased beta chemokine secretion in Ethiopians: relevance to AIDS in Africa. J Hum Virol 1999; 2:283-289.
    • (1999) J Hum Virol , vol.2 , pp. 283-289
    • Kalinkovich, A.1    Weisman, Z.2    Leng, Q.3    Borkow, G.4    Stein, M.5    Greenberg, Z.6
  • 26
    • 77955430749 scopus 로고    scopus 로고
    • Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa
    • Cohen CR, Moscicki AB, Scott ME, Ma Y, Shiboski S, Bukusi E, et al. Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa. AIDS 2010; 24:2069-2074.
    • (2010) AIDS , vol.24 , pp. 2069-2074
    • Cohen, C.R.1    Moscicki, A.B.2    Scott, M.E.3    Ma, Y.4    Shiboski, S.5    Bukusi, E.6
  • 27
    • 17644382251 scopus 로고    scopus 로고
    • Amplified HIV transmission and new approaches to HIV prevention
    • Cohen MS, Pilcher CD. Amplified HIV transmission and new approaches to HIV prevention. J Infect Dis 2005; 191:1391- 1393.
    • J Infect Dis 2005 , vol.191 , pp. 1391-1393
    • Cohen, M.S.1    Pilcher, C.D.2
  • 28
    • 85027958165 scopus 로고    scopus 로고
    • Extended high viremics: A substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection
    • Novitsky V, Ndung'u T, Wang R, Bussmann H, Chonco F, Makhema J, et al. Extended high viremics: A substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS 2011; 25:1515- 1522.
    • (2011) AIDS , vol.25 , pp. 1515-1522
    • Novitsky, V.1    Ndung'u, T.2    Wang, R.3    Bussmann, H.4    Chonco, F.5    Makhema, J.6
  • 29
    • 0033929541 scopus 로고    scopus 로고
    • Evaluation of performance of the gen-probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya
    • Emery S, Bodrug S, Richardson BA, Giachetti C, Bott MA, Panteleeff D, et al. Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya. J Clin Microbiol 2000; 38:2688-2695.
    • (2000) J Clin Microbiol , vol.38 , pp. 2688-2695
    • Emery, S.1    Bodrug, S.2    Richardson, B.A.3    Giachetti, C.4    Bott, M.A.5    Panteleeff, D.6
  • 30
    • 17344371256 scopus 로고    scopus 로고
    • High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa
    • Dyer JR, Kazembe P, Vernazza PL, Gilliam BL, Maida M, Zimba D, et al. High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa. J Infect Dis 1998; 177:1742-1746.
    • (1998) J Infect Dis , vol.177 , pp. 1742-1746
    • Dyer, J.R.1    Kazembe, P.2    Vernazza, P.L.3    Gilliam, B.L.4    Maida, M.5    Zimba, D.6
  • 31
    • 70350225358 scopus 로고    scopus 로고
    • Viral load levels measured at set-point have risen over the last decade of the HIV epidemic in the Netherlands
    • Gras L, Jurriaans S, Bakker M, van Sighem A, Bezemer D, Fraser C, et al. Viral load levels measured at set-point have risen over the last decade of the HIV epidemic in the Netherlands. PLoS One 2009; 4:e7365.
    • (2009) PLoS One , vol.4
    • Gras, L.1    Jurriaans, S.2    Bakker, M.3    Van Sighem, A.4    Bezemer, D.5    Fraser, C.6
  • 32
    • 67651092167 scopus 로고    scopus 로고
    • African descent is associated with slower CD4 cell count decline in treatment-naive patients of the Swiss HIV Cohort Study
    • Muller V, von Wyl V, Yerly S, Boni J, Klimkait T, Burgisser P, et al. African descent is associated with slower CD4 cell count decline in treatment-naive patients of the Swiss HIV Cohort Study. AIDS 2009; 23:1269-1276.
    • (2009) AIDS , vol.23 , pp. 1269-1276
    • Muller, V.1    Von Wyl, V.2    Yerly, S.3    Boni, J.4    Klimkait, T.5    Burgisser, P.6
  • 33
    • 80051616486 scopus 로고    scopus 로고
    • HIV-malaria co-infection: Effects of malaria on the prevalence of HIV in East sub- Saharan Africa
    • Cuadros DF, Branscum AJ, Crowley PH. HIV-malaria co-infection: effects of malaria on the prevalence of HIV in East sub- Saharan Africa. Int J Epidemiol 2011; 40:931-939.
    • (2011) Int J Epidemiol , vol.40 , pp. 931-939
    • Cuadros, D.F.1    Branscum, A.J.2    Crowley, P.H.3
  • 34
    • 58549113211 scopus 로고    scopus 로고
    • Heterosexual risk of HIV-1 infection per sexual act: Systematic review and meta-analysis of observational studies
    • Boily MC, Baggaley RF, Wang L, Masse B, White RG, Hayes RJ, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis 2009; 9:118-129.
    • (2009) Lancet Infect Dis , vol.9 , pp. 118-129
    • Boily, M.C.1    Baggaley, R.F.2    Wang, L.3    Masse, B.4    White, R.G.5    Hayes, R.J.6
  • 35
    • 77953293984 scopus 로고    scopus 로고
    • Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis
    • Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, Cohen CR, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis. Lancet 2010; 375:2092-2098.
    • (2010) Lancet , vol.375 , pp. 2092-2098
    • Donnell, D.1    Baeten, J.M.2    Kiarie, J.3    Thomas, K.K.4    Stevens, W.5    Cohen, C.R.6
  • 37
    • 78349239613 scopus 로고    scopus 로고
    • Treatment of sexually transmitted infections for HIV prevention: End of the road or new beginning?
    • Hayes R, Watson-Jones D, Celum C, van de Wijgert J, Wasserheit J. Treatment of sexually transmitted infections for HIV prevention: end of the road or new beginning? AIDS 2010; 24 (Suppl 4):S15-S26.
    • (2010) AIDS , vol.24 , Issue.SUPPL. 4
    • Hayes, R.1    Watson-Jones, D.2    Celum, C.3    Van De Wijgert, J.4    Wasserheit, J.5
  • 38
    • 81055124981 scopus 로고    scopus 로고
    • Time to refocus on HSV interventions for HIV prevention?
    • Tanton C, Abu-Raddad LJ, Weiss HA. Time to refocus on HSV interventions for HIV prevention? J Infect Dis 2011; 204:1822- 1826.
    • (2011) J Infect Dis , vol.204 , pp. 1822-1826
    • Tanton, C.1    Abu-Raddad, L.J.2    Weiss, H.A.3


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