Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection Mediated Apoptosis in B- and T-Cell Areas in Lymphoid Organs of Experimentally Infected Pigs

Transboundary and Emerging Diseases

Volumn 60, Issue 3, 2013, Pages 273-278

  Gomez Laguna J ^a   Salguero, F J ^b   Fernandez de Marco M ^c   Barranco, I ^c   Rodriguez Gomez I M ^c   Quezada, M ^d   Carrasco, L ^c  

^a CICAP Agrifood Research Center   (Spain)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

^c UNIVERSITY OF CÓRDOBA   (Spain)

^d UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Apoptosis; Immunohistochemistry; Lymphoid organs; PRRSV; TUNEL

Indexed keywords

MESSENGER RNA; VIRUS ANTIGEN; VIRUS RNA;

ANIMAL; APOPTOSIS; ARTERIVIRUS; ARTICLE; B LYMPHOCYTE; BLOOD; ENZYME IMMUNOASSAY; GENETICS; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MEDIASTINUM; NICK END LABELING; PALATINE TONSIL; PATHOLOGY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; T LYMPHOCYTE; VIREMIA; VIROLOGY;

ANIMALS; ANTIGENS, VIRAL; APOPTOSIS; B-LYMPHOCYTES; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MEDIASTINUM; PALATINE TONSIL; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, VIRAL; SWINE; T-LYMPHOCYTES; VIREMIA;

ANIMALIA; ARTERIVIRUS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE;

EID: 84876412638     PISSN: 18651674     EISSN: 18651682     Source Type: Journal    
DOI: 10.1111/j.1865-1682.2012.01338.x     Document Type: Article

References (24)

1. Carrasco, L., F. Chacón-M de Lara, J. Martín de las Mulas, J. C. Gómez-Villamandos, J. Pérez, P. J. Wilkinson, and M. A. Sierra, 1996: Apoptosis in lymph nodes in acute African swine fever. J. Comp. Pathol.115, 415-428.
2. Chang, H. W., C. R. Jeng, C. M. Lin, J. J. Liu, C. C. Chang, Y. C. Tsai, M. Y. Chia, and V. F. Pang, 2007: The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro. Vet. Microbiol.122, 72-82.
3. Choi, C., and C. Chae, 2002: Expression of tumour necrosis factor-α is associated with apoptosis in lungs of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Res. Vet. Sci.72, 45-49.
4. Christopher-Hennings, J., E. A. Nelson, J. K. Nelson, K. D. Rossow, J. L. Shivers, M. J. Yaeger, C. C. Chase, R. A. Garduno, J. E. Collins, and D. A. Benfield, 1998: Identification of porcine reproductive and respiratory syndrome virus in semen and tissues from vasectomized and nonvasectomized boars. Vet. Pathol.35, 260-267.
5. Costers, S., D. J. Lefebvre, P. L. Delputte, and H. J. Nauwynck, 2008: Porcine reproductive and respiratory syndrome virus modulates apoptosis during replication in alveolar macrophages. Arch. Virol.153, 1453-1465.
6. Díaz, I., L. Darwich, G. Pappaterra, J. Pujols, and E. Mateu, 2005: Immune responses of pigs after experimental infection with a European strain of porcine reproductive and respiratory syndrome virus. J. Gen. Virol.86, 1943-1951.
7. Díaz, I., L. Darwich, G. Pappaterra, J. Pujols, and E. Mateu, 2006: Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Virology351, 249-259.
8. Duan, X., H. J. Nauwynck, and M. B. Pensaert, 1997: Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol.56, 9-19.
9. Gómez-Laguna, J., F. J. Salguero, I. Barranco, F. J. Pallarés, I. M. Rodríguez-Gómez, A. Bernabé, and L. Carrasco, 2010: Cytokine expression by macrophages in the lung of pigs infected with the porcine reproductive and respiratory syndrome virus. J. Comp. Pathol.142, 51-60.
10. Halbur, P. G., P. S. Paul, X. J. Meng, M. A. Lum, J. J. Andrews, and J. A. Rathje, 1996: Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model. J. Vet. Diagn. Invest.8, 11-20.
11. Labarque, G., S. Van Gucht, H. Nauwynck, K. Van Reeth, and M. Pensaert, 2003: Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines. Vet. Res.34, 249-260.
12. Lawson, S. R., K. D. Rossow, J. E. Collins, D. A. Benfield, and R. R. Rowland, 1997: Porcine reproductive and respiratory syndrome virus infection of gnotobiotic pigs: sites of virus replication and co-localization with MAC-387 staining at 21days post-infection. Virus Res.51, 105-113.
13. Majno, G., and I. Joris, 1995: Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol.146, 3-15.
14. Quezada, M., F. Varas, A. Ruíz, A. Islas, N. Díaz, and C. Lecocq, 2004: Immunohistochemical detection of PRRS virus antigen in inoculated pigs. Arch. Med. Vet.36, 183-195 (In Spanish Abstract in English).
15. Ramírez, E., V. Moreno, N. Díaz, F. Osorio, A. Ruíz, V. Neira, and M. Quezada, 2007: Evaluation of the pathogenicity and transmissibility of a Chilean Isolate of Porcine Reproductive and Respiratory Syndrome Virus. J. Vet. Med. A, Physiol. Pathol. Clin. Med.54, 1-8.
16. Rossow, K. D., J. E. Collins, S. M. Goyal, E. A. Nelson, J. Christopher-Hennings, and D. A. Benfield, 1995: Pathogenesis of porcine reproductive and respiratory syndrome virus infection in gnotobiotic pigs. Vet. Pathol.32, 361-373.
17. Salguero, F. J., P. J. Sánchez-Cordón, A. Núñez, M. Fernández de Marco, and J. C. Gómez-Villamandos, 2005: Proinflammatory cytokines induce lymphocyte apoptosis in acute African Swine Fever infection. J. Comp. Pathol.132, 289-302.
18. Sinha, A., S. Schalk, K. M. Lager, C. Wang, and T. Opriessnig, 2012: Singular PCV2a or PCV2b infection results in apoptosis of hepatocytes in clinically affected gnotobiotic pigs. Res. Vet. Sci.92, 151-156.
19. Sirinarumitr, T., Y. Zhang, J. P. Kluge, P. G. Halbur, and P. S. Paul, 1998: A pneumo-virulent United States isolate of porcine reproductive and respiratory syndrome virus induces apoptosis in bystander cells both in vitro and in vivo. J. Gen. Virol.79, 2989-29995.
20. Suárez, P., 2000: Ultrastructural pathogenesis of the PRRS virus. Vet. Res.31, 47-55.
21. Sur, J. H., A. R. Doster, and F. A. Osorio, 1998: Apoptosis induced in vivo during acute infection by porcine reproductive and respiratory syndrome virus. Vet. Pathol.35, 506-514.
22. Thomson, B. J., 2001: Viruses and apoptosis. Int. J. Exp. Pathol.82, 65-76.
23. Wills, R. W., A. R. Doster, J. A. Galeota, J. H. Sur, and F. A. Osorio, 2003: Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus. J. Clin. Microbiol.41, 58-62.
24. Xiao, Z., L. Batista, S. Dee, P. Halbur, and M. P. Murtaugh, 2004: The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load. J. Virol.78, 5923-5933.