The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro

Veterinary Microbiology

Volumn 122, Issue 1-2, 2007, Pages 72-82

  Chang, Hui Wen ^a   Jeng, Chian Ren ^a   Lin, Chun Ming ^a   Liu, Jiuan Judy ^a,b   Chang, Chih Cheng ^c   Tsai, Yi Chieh ^a   Chia, Mi Yuan ^a   Pang, Victor Fei ^a,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b Center for Drug Evaluation   (Taiwan)

^c NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^d Department of Veterinary Medicine   (Taiwan)

Author keywords

Apoptosis; Fas FasL; Porcine circovirus type 2 (PCV2); Porcine reproductive and respiratory syndrome virus (PRRSV); Postweaning multisystemic wasting syndrome (PMWS)

Indexed keywords

FAS ANTIGEN; FAS LIGAND;

ANIMAL CELL; APOPTOSIS; ARTERIVIRUS; ARTICLE; CELL SURVIVAL; CIRCOVIRIDAE; COCULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; INOCULATION; LEUKEMIA CELL LINE; LYMPHOCYTE DEPLETION; MACROPHAGE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PORCINE CIRCOVIRUS 2; POSTWEANING MULTISYSTEMIC WASTING SYNDROME; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SPLEEN CELL; SUPERINFECTION; SWINE DISEASE; SYSTEMIC DISEASE; WASTING SYNDROME;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CIRCOVIRUS; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; LYMPHOCYTES; MACROPHAGES; MALE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RNA, MESSENGER; SPLEEN; SWINE;

PORCINE CIRCOVIRUS 2; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE;

EID: 34247097407     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2007.01.013     Document Type: Article

References (43)

1. Alderson M.R., Tough T.W., Braddy S., Davis-Smith T., Roux E., Schooley K., Miller R.E., and Lynch D.H. Regulation of apoptosis and T cell activation by Fas-specific mAb. Int. Immunol. 6 (1994) 1799-1806
2. Alderson M.R., Tough T.W., Davis-Smith T., Braddy S., Falk B., Schooley K.A., Goodwin R.G., Smith C.A., Ramsdell F., and Lynch D.H. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181 (1995) 71-77
3. Allan G.M., and Ellis J.A. Porcine circoviruses: a review. J. Vet. Diagn. Invest. 12 (2000) 3-14
4. Allan G.M., McNeilly F., Ellis J., Krakowka S., Meehan B., McNair I., Walker I., and Kennedy S. Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication. Arch. Virol. 145 (2000) 2421-2429
5. Badley A.D., McElhinny J.A., Leibson P.J., Lynch D.H., Alderson M.R., and Paya C.V. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J. Virol. 70 (1996) 199-206
6. Bai L., Maedler K., Donath M., and Tuch B.E. Expression of Fas but not Fas ligand on fetal pig beta cells. Xenotransplantation 11 (2004) 426-435
7. Boise L.H., and Thompson C.B. Hierarchical control of lymphocyte survival. Science 274 (1996) 67-68
8. Chang H.W., Jeng C.R., Lin T.L., Liu J.J., Chiou M.T., Tsai Y.C., Chia M.Y., Jan T.R., and Pang V.F. Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation. Vet. Immunol. Immunopathol. 110 (2006) 207-219
9. Chang H.W., Jeng C.R., Liu J.J., Lin T.L., Chang C.C., Chia M.Y., Tsai Y.C., and Pang V.F. Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha. Vet. Microbiol. 108 (2005) 167-177
10. Choi C., and Chae C. Expression of tumour necrosis factor-alpha is associated with apoptosis in lungs of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Res. Vet. Sci. 72 (2002) 45-49
11. Chung C.S., Wang W., Chaudry I.H., and Ayala A. Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (2001) G812-G818
12. Darwich L., Segales J., Domingo M., and Mateu E. Changes in CD4(+), CD8(+), CD4(+) CD8(+), and immunoglobulin M-positive peripheral blood mononuclear cells of postweaning multisystemic wasting syndrome-affected pigs and age-matched uninfected wasted and healthy pigs correlate with lesions and porcine circovirus type 2 load in lymphoid tissues. Clin. Diagn. Lab. Immunol. 9 (2002) 236-242
13. De Milito A., Morch C., Sonnerborg A., and Chiodi F. Loss of memory (CD27) B lymphocytes in HIV-1 infection. AIDS 15 (2001) 957-964
14. Dorn A.D., Waters W.R., Byers V.M., Pesch B.A., and Wannemuehler M.J. Characterization of mitogen-stimulated porcine lymphocytes using a stable fluorescent dye (PKH2) and multicolor flow cytometry. Vet. Immunol. Immunopathol. 87 (2002) 1-10
15. Gilpin D.F., McCullough K., Meehan B.M., McNeilly F., McNair I., Stevenson L.S., Foster J.C., Ellis J.A., Krakowka S., Adair B.M., and Allan G.M. In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system. Vet. Immunol. Immunopathol. 94 (2003) 149-161
16. Harms P.A., Sorden S.D., Halbur P.G., Bolin S.R., Lager K.M., Morozov I., and Paul P.S. Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus. Vet. Pathol. 38 (2001) 528-539
17. Iken K., Huang L., Bekele H., Schmidt E.V., and Koziel M.J. Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction. Virology 346 (2006) 363-372
18. Kawashima K., Narita M., and Yamada S. Changes in macrophage and lymphocyte subpopulations of lymphoid tissues from pigs infected with the porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Immunol. Immunopathol. 71 (1999) 257-262
19. Kim J., and Chae C. Necrotising lymphadenitis associated with porcine circovirus type 2 in pigs. Vet. Rec. 156 (2005) 177-178
20. Krakowka S., Ellis J.A., McNeilly F., Gilpin D., Meehan B., McCullough K., and Allan G. Immunologic features of porcine circovirus type 2 infection. Viral Immunol. 15 (2002) 567-582
21. Labarque G., Van Gucht S., Nauwynck H., Van Reeth K., and Pensaert M. Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines. Vet. Res. 34 (2003) 249-260
22. Lamontagne L., Page C., Larochelle R., Longtin D., and Magar R. Polyclonal activation of B cells occurs in lymphoid organs from porcine reproductive and respiratory syndrome virus (PRRSV)-infected pigs. Vet. Immunol. Immunopathol. 82 (2001) 165-182
23. Lemke C.D., Haynes J.S., Spaete R., Adolphson D., Vorwald A., Lager K., and Butler J.E. Lymphoid hyperplasia resulting in immune dysregulation is caused by porcine reproductive and respiratory syndrome virus infection in neonatal pigs. J. Immunol. 172 (2004) 1916-1925
24. Liu J., Chen I., and Kwang J. Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis. J. Virol. 79 (2005) 8262-8274
25. Mandrioli L., Sarli G., Panarese S., Baldoni S., and Marcato P.S. Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS). Vet. Immunol. Immunopathol. 97 (2004) 25-37
26. Resendes A.R., Majo N., Segales J., Mateu E., Calsamiglia M., and Domingo M. Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2. J. Gen. Virol. 85 (2004) 2837-2844
27. Revilla C., Alvarez B., López-Fraga M., Chamorro S., Martínez P., Ezquerra A., Alonso F., and Domínguez J. Differential expression of chemokine receptore and CD95 in porcine CD4+ T cell subsets. Vet. Immunol. Immunopathol. 106 (2005) 295-301
28. Rovira A., Balasch M., Segales J., Garcia L., Plana-Duran J., Rosell C., Ellerbrok H., Mankertz A., and Domingo M. Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. J. Virol. 76 (2002) 3232-3239
29. Sarli G., Mandrioli L., Laurenti M., Sidoli L., Cerati C., Rolla G., and Marcato P.S. Immunohistochemical characterisation of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS). Vet. Immunol. Immunopathol. 83 (2001) 53-67
30. Segales J., Alonso F., Rosell C., Pastor J., Chianini F., Campos E., Lopez-Fuertes L., Quintana J., Rodriguez-Arrioja G., Calsamiglia M., Pujols J., Dominguez J., and Domingo M. Changes in peripheral blood leukocyte populations in pigs with natural postweaning multisystemic wasting syndrome (PMWS). Vet. Immunol. Immunopathol. 81 (2001) 37-44
31. Segales J., and Domingo M. Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Vet. Q 24 (2002) 109-124
32. Segales J., Domingo M., Chianini F., Majo N., Dominguez J., Darwich L., and Mateu E. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet. Microbiol. 98 (2004) 151-158
33. Segales J., Rosell C., and Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Vet. Microbiol. 98 (2004) 137-149
34. Seli E., Guzeloglu-Kayisli O., Cakmak H., Kayisli U.A., Selam B., and Arici A. Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression. J. Clin. Endocrinol. Metab. 91 (2006) 4995-5001
35. Shibahara T., Sato K., Ishikawa Y., and Kadota K. Porcine circovirus induces B lymphocyte depletion in pigs with wasting disease syndrome. J. Vet. Med. Sci. 62 (2000) 1125-1131
36. Sirinarumitr T., Zhang Y., Kluge J.P., Halbur P.G., and Paul P.S. A pneumo-virulent United States isolate of porcine reproductive and respiratory syndrome virus induces apoptosis in bystander cells both in vitro and in vivo. J. Gen. Virol. 79 (1998) 2989-2995
37. Suarez P., Diaz-Guerra M., Prieto C., Esteban M., Castro J.M., Nieto A., and Ortin J. Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis. J. Virol. 70 (1996) 2876-2882
38. Summerfield A., Knötig S.M., and McCullough K.C. Lymphocyte apoptosis during classical swine fever: implication of activation-induced cell death. J. Virol. 72 (1998) 1853-1861
39. Sur J.H., Doster A.R., and Osorio F.A. Apoptosis induced in vivo during acute infection by porcine reproductive and respiratory syndrome virus. Vet. Pathol. 35 (1998) 506-514
40. Teague T.K., Marrack P., Kappler J.W., and Vella A.T. IL-6 rescues resting mouse T cells from apoptosis. J. Immunol. 158 (1997) 5791-5796
41. Tsuyuki S., Kono M., and Bloom E.T. Cloning and potential utility of porcine Fas ligand: overexpression in porcine endothelial cells protects them from attack by human cytolytic cells. Xenotransplantation 9 (2002) 410-421
42. Vincent I.E., Carrasco C.P., Herrmann B., Meehan B.M., Allan G.M., Summerfield A., and McCullough K.C. Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus. J. Virol. 77 (2003) 13288-13300
43. Wellenberg G.J., Stockhofe-Zurwieden N., Boersma W.J., De Jong M.F., and Elbers A.R. The presence of co-infections in pigs with clinical signs of PMWS in The Netherlands: a case-control study. Res. Vet. Sci. 77 (2004) 177-184