Aerobic interval exercise training in the afternoon reduces attacks of coronary spastic angina in conjunction with improvement in endothelial function, oxidative stress, and inflammation

Coronary Artery Disease

Volumn 24, Issue 3, 2013, Pages 177-182

  Morikawa, Yoshinobu ^a,b   Mizuno, Yuji ^a   Harada, Eisaku ^a   Katoh, Daisuke ^a,c   Kashiwagi, Yusuke ^a,c   Morita, Sumio ^a   Yoshimura, Michihiro ^c   Uemura, Shiro ^d   Saito, Yoshihiko ^d   Yasue, Hirofumi ^a  

^a Division of Cardiovascular Medicine   (Japan)

^b Nara City Hospital   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

aerobic interval exercise training; coronary spasm; coronary spastic angina; endothelial function; flow mediated dilatation

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE;

ADULT; AEROBIC EXERCISE; AEROBIC INTERVAL EXERCISE TRAINING; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR FUNCTION; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CORONARY ARTERY DILATATION; CORONARY ARTERY SPASM; ENDOTHELIUM; FEMALE; HOMEOSTASIS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

AGED; ANGINA PECTORIS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CIRCADIAN RHYTHM; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY VASOSPASM; ENDOTHELIUM, VASCULAR; EXERCISE THERAPY; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; MIDDLE AGED; OXIDATIVE STRESS; PILOT PROJECTS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TREATMENT OUTCOME; VASODILATION;

EID: 84876409300     PISSN: 09546928     EISSN: 14735830     Source Type: Journal    
DOI: 10.1097/MCA.0b013e32835cbef5     Document Type: Article

References (29)

1. Yasue H, Nakagawa A, Itoh T, Harada E, Mizuno Y. Coronary artery spasm - clinical features, diagnosis, pathogenesis, and treatment. J Cardiol 2008; 51:2-17. (Pubitemid 351709406)
2. Maseri A, Beltrame JF, Shimokawa H. Role of coronary vasoconstriction in ischemic heart disease and search for novel therapeutic targets. Circ J 2009; 73:394-403.
3. Kugiyama K, Yasue H, Okumura K, Ogawa H, Fujimoto K, Nakao K, et al. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation 1996; 94:266-271.
4. Kugiyama K, Sugiyama S, Soejima H, Kawano H, Sakamoto T, Takazoe K, et al. Increase in plasma levels of oxidized low-density lipoproteins in patients with coronary spastic angina. Atherosclerosis 2001; 154: 463-467. (Pubitemid 32146620)
5. Itoh T, Mizuno Y, Harada E, Yoshimura M, Ogawa H, Yasue H. Coronary spasm is associated with chronic low-grade inflammation. Circ J 2007; 71:1074-1078. (Pubitemid 46998022)
6. Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, et al. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: a possible role of reactive oxygen species. J Am Coll Cardiol 2000; 35:1860-1866. (Pubitemid 30342868)
7. Clarkson P, Montgomery HE, Mullen MJ, Donald AE, Powe AJ, Bull T, et al. Exercise training enhances endothelial function in young men. J Am Coll Cardiol 1999; 33:1379-1385.
8. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003; 107:3152-3158. (Pubitemid 36793084)
9. Laufs U, Wassmann S, Czech T, Münzel T, Eisenhauer M, Böhm M, et al. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 2005; 25: 809-814. (Pubitemid 40463874)
10. Gielen S, Schuler G, Adams V. Cardiovascular effects of exercise training: molecular mechanisms. Circulation 2010; 122:1221-1238.
11. Kawano H, Motoyama T, Yasue H, Hirai N, Waly HM, Kugiyama K, et al. Endothelial function fluctuates with diurnal variation in the frequency of ischemic episodes in patients with variant angina. J Am Coll Cardiol 2002; 40:266-270. (Pubitemid 34756286)
12. Otto ME, Svatikova A, Barretto RB, Santos S, Hoffmann M, Khandheria B, et al. Early morning attenuation of endothelial function in healthy humans. Circulation 2004; 109:2507-2510. (Pubitemid 38720548)
13. Yasue H, Omote S, Takizawa A, Nagao M, Miwa K, Tanaka S. Circadian variation of exercise capacity in patients with Prinzmetal's variant angina: role of exercise-induced coronary arterial spasm. Circulation 1979; 59: 938-948. (Pubitemid 9163952)
14. Waters DD, Miller DD, Bouchard A, Bosch X, Theroux P. Circadian variation in variant angina. Am J Cardiol 1984; 54:61-64. (Pubitemid 14085350)
15. Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 2007; 115:3086-3094. (Pubitemid 46956498)
16. Cornish AK, Broadbent S, Cheema BS. Interval training for patients with coronary artery disease: a systematic review. Eur J Appl Physiol 2011; 111:579-589.
17. Gibala MJ, Little JP, Macdonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 2012; 590:1077-1084.
18. Yasue H, Horio Y, Nakamura N, Fujii H, Imoto N, Sonoda R, et al. Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. Circulation 1986; 74:955-963. (Pubitemid 17174941)
19. Swain DP. Cardio respiratory exercise prescription. In: Ehrman JK, editor. ACSM' resource manual for guidelines for exercise testing and prescription. Philadelphia: Wolters Kluwer; 2010. pp. 448-462.
20. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. International brachial artery reactivity task force. guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force. J Am Coll Cardiol 2002; 39:257-265. (Pubitemid 34084631)
21. Vassalle C, Boni C, Di Cecco P, Ndreu R, Zucchelli GC. Automation and validation of a fast method for the assessment of in vivo oxidative stress levels. Clin Chem Lab Med 2006; 44:1372-1375. (Pubitemid 44706719)
22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419. (Pubitemid 15018832)
23. Waters DD, Szlachcic J, Bourassa MG, Scholl JM, Théroux P. Exercise testing in patients with variant angina: results, correlation with clinical and angiographic features and prognostic significance. Circulation 1982; 65:265-274. (Pubitemid 12219018)
24. Harrison DG, Widder J, Grumbach I, Chen W, Weber M, Searles C. Endothelial mechanotransduction, nitric oxide and vascular inflammation. J Intern Med 2006; 259:351-363. (Pubitemid 43384226)
25. JCS Joint Working Group. Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina) (JCS 2008): digest version. Circ J 2010; 74:1745-1762.
26. Yasue H, Mizuno Y, Harada E, Itoh T, Nakagawa H, Nakayama M, et al. Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers. Statin and Coronary Artery Spasm Trial Investigators. J Am Coll Cardiol 2008; 51:1742-1748. (Pubitemid 351608498)
27. Maseri A, Chierchia S, Davies GJ, Fox KM. Variable susceptibility to dynamic coronary obstruction: an elusive link between coronary atherosclerosis and angina pectoris. Am J Cardiol 1983; 52:46A-51A. (Pubitemid 13026289)
28. Walling A, Waters DD, Miller DD, Roy D, Pelletier GB, Théroux P. Long-term prognosis of patients with variant angina. Circulation 1987; 76:990-997. (Pubitemid 17157279)
29. Yasue H, Takizawa A, Nagao M, Nishida S, Horie M, Kubota J, et al. Longterm prognosis for patients with variant angina and influential factors. Circulation 1988; 78:1-9.