Aminolevulinic acid (ALA): Photodynamic detection and potential therapeutic applications

Journal of Surgical Research

Volumn 181, Issue 2, 2013, Pages 262-271

  Nokes, Brandon ^a   Apel, Matt ^a   Jones, Carol ^a   Brown, Gabrielle ^a   Lang, Julie E ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

ALA; Aminolevulinic acid; Cancer; Fluorescence; Photodynamic

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID HEXYL ESTER; HEMATOPORPHYRIN DERIVATIVE; PHOTOFRIN;

ASTROCYTOMA; B CELL LYMPHOMA; BARRETT ESOPHAGUS; BILE DUCT CANCER; BILE DUCT CARCINOMA; BLADDER CANCER; BONE CANCER; BREAST CANCER; BREAST CARCINOMA; BRONCHUS CANCER; CANCER DIAGNOSIS; CANCER SURGERY; CYSTOSCOPY; DRUG APPROVAL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG UPTAKE; FIBROADENOMA; FLUORESCENCE; GLIOBLASTOMA; HEAD AND NECK CANCER; HEPATOBLASTOMA; HUMAN; HYPOTENSION; INTRADUCTAL CARCINOMA; KIDNEY CARCINOMA; LEUKOPLAKIA; LIVER CANCER; LIVER CELL CARCINOMA; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; MENINGIOMA; NASOPHARYNX CARCINOMA; NAUSEA; NEUROBLASTOMA; NONHUMAN; OSTEOMYELITIS; OSTEOSARCOMA; OVARY CANCER; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHOTODYNAMIC THERAPY; PHOTODYNAMICS; PHOTOSENSITIVITY; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SENSITIVITY AND SPECIFICITY; SIDE EFFECT; SKIN CANCER; STOMACH CANCER; TACHYCARDIA; URINARY FREQUENCY; UTERINE CERVIX CARCINOMA IN SITU; VOMITING;

AMINOLEVULINIC ACID; ANTINEOPLASTIC AGENTS; DRUG ADMINISTRATION ROUTES; DRUG APPROVAL; HUMANS; NEOPLASMS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84876409192     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.02.002     Document Type: Review

References (94)

1. G.A. Hunter, and G.C. Ferreira Molecular enzymology of 5-aminolevulinate synthase, the gatekeeper of heme biosynthesis Biochim Biophys Acta 1814 2011 1467
2. B. Krammer, and K. Plaetzer ALA and its clinical impact, from bench to bedside Photochem Photobiol Sci 7 2008 283
3. E.A. Hryhorenko, A.R. Oseroff, J. Morgan, and K. Rittenhouse-Diakun Antigen specific and nonspecific modulation of the immune response by aminolevulinic acid based photodynamic therapy Immunopharmacology 40 1998 231
4. K.A. Frei, H.M. Bonel, and H. Frick Photodynamic detection of diseased axillary sentinel lymph node after oral application of aminolevulinic acid in patients with breast cancer Br J Cancer 90 2004 805
5. S.L. Gibbs, B. Chen, and J.A. O'Hara Protoporphyrin IX level correlates with number of mitochondria, but increase in production correlates with tumor cell size Photochem Photobiol 82 2006 1334
6. R.C. Krieg, S. Fickweiler, and O.S. Wolfbeis Cell-type specific protoporphyrin IX metabolism in human bladder cancer in vitro Photochem Photobiol 72 2000 226
7. A. Juarranz, P. Jaen, and F. Sanz-Rodriguez Photodynamic therapy of cancer. Basic principles and applications Clin Transl Oncol 10 2008 148
8. X. Li, Z.P. Zhou, L. Hu, W.J. Zhang, and W. Li Apoptotic cell death induced by 5-aminolaevulinic acid-mediated photodynamic therapy of hypertrophic scar-derived fibroblasts J Dermatolog Treat 2013 in press
9. M.G. Alvarez, M.S. Lacelli, and V. Rivarola 5-Aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells J Environ Pathol Toxicol Oncol 26 2007 75
10. D.P. Ladner, R.A. Steiner, and J. Allemann Photodynamic diagnosis of breast tumours after oral application of aminolevulinic acid Br J Cancer 84 2001 33
11. N. Fotinos, M.A. Campo, F. Popowycz, R. Gurny, and N. Lange 5-Aminolevulinic acid derivatives in photomedicine: characteristics, application and perspectives Photochem Photobiol 82 2006 994
12. C.A. Morton Topical photodynamic therapy in dermatology S Afr Med J 91 2001 634
13. C. Perotti, H. Fukuda, and G. DiVenosa Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies Br J Cancer 90 2004 1660
14. P.A. Valdes, Z.B. Moses, and A. Kim Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown J Neuropathol Exp Neurol 71 2012 806
15. N.G. Egger, M. Motamedi, and M. Pow-Sang Accumulation of porphyrins in plasma and tissues of dogs after delta-aminolevulinic acid administration: implications for photodynamic therapy Pharmacology 52 1996 362
16. M. Haedersdal, J. Katsnelson, and F.H. Sakamoto Enhanced uptake and photoactivation of topical methyl aminolevulinate after fractional CO2 laser pretreatment Lasers Surg Med 43 2011 804
17. C.B. Warren, L.J. Karai, and A. Vidimos Pain associated with aminolevulinic acid-photodynamic therapy of skin disease J Am Acad Dermatol 61 2009 1033
18. R. Waidelich, H. Stepp, and R. Baumgartner Clinical experience with 5-aminolevulinic acid and photodynamic therapy for refractory superficial bladder cancer J Urol 165 2001 1904
19. S.R. Millon, J.H. Ostrander, and S. Yazdanfar Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes J Biomed Opt 15 2010 018002
20. S.A. Ziegler, C. Loucks, S.J. Madsen, and S.W. Carper Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells J Environ Pathol Toxicol Oncol 26 2007 173
21. A.M. Dorward, K.S. Fancher, and T.M. Duffy Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation Br J Cancer 93 2005 1137
22. M.K. Nottage, K.A. Kopciuk, and A. Tzontcheva Analysis of incidence and prognostic factors for ipsilateral breast tumour recurrence and its impact on disease-specific survival of women with node-negative breast cancer: a prospective cohort study Breast Cancer Res 8 2006 R44
23. V. Manivasager, P.W. Heng, and J. Hao A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer Int J Oncol 22 2003 313
24. J. Schmidbauer, F. Witjes, and N. Schmeller Improved detection of urothelial carcinoma in situ with hexaminolevulinate fluorescence cystoscopy J Urol 171 2004 135
25. J.A. Witjes, P.M. Moonen, and A.G. van der Heijden Comparison of hexaminolevulinate based flexible and rigid fluorescence cystoscopy with rigid white light cystoscopy in bladder cancer: results of a prospective Phase II study Eur Urol 47 2005 319
26. W. Loidl, J. Schmidbauer, and M. Susani Flexible cystoscopy assisted by hexaminolevulinate induced fluorescence: a new approach for bladder cancer detection and surveillance? Eur Urol 47 2005 323
27. P. Jichlinski, L. Guillou, and S.J. Karlsen Hexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer-a multicenter study J Urol 170 2003 226
28. D. Zaak, A. Karl, and R. Knuchel Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopy BJU Int 96 2005 217
29. H.B. Grossman Improving the management of bladder cancer with fluorescence cystoscopy J Environ Pathol Toxicol Oncol 26 2007 143
30. Storz K. Karl Storz Photodynamic Diagnostic D-Light C (PDD) System. In: FDA, editor. http://www.accessdata.fda.gov/cdrh-docs/pdf5/P050027a.pdf; 2010 [accessed October, 2012].
31. D. Jocham, F. Witjes, and S. Wagner Improved detection and treatment of bladder cancer using hexaminolevulinate imaging: a prospective, phase III multicenter study J Urol 174 2005 862 discussion 866
32. Z. Xiao, Y. Tamimi, and K. Brown Interstitial photodynamic therapy in subcutaneously implanted urologic tumors in rats after intravenous administration of 5-aminolevulinic acid Urol Oncol 7 2002 125
33. S.M. Sultan, A.A. El-Doray, and A. Hofstetter Photodynamic selectivity of 5-aminolevulinic acid to prostate cancer cells J Egypt Natl Canc Inst 18 2006 382
34. C. Adam, G. Salomon, and S. Walther Photodynamic diagnosis using 5-aminolevulinic acid for the detection of positive surgical margins during radical prostatectomy in patients with carcinoma of the prostate: a multicentre, prospective, phase 2 trial of a diagnostic procedure Eur Urol 55 2009 1281
35. P. Collinet, F. Sabban, and M. Cosson Laparoscopic photodynamic diagnosis of ovarian cancer peritoneal micro metastasis: an experimental study Photochem Photobiol 83 2007 647
36. J.K. Chan, B.J. Monk, and D. Cuccia Laparoscopic photodynamic diagnosis of ovarian cancer using 5-aminolevulinic acid in a rat model Gynecol Oncol 87 2002 64
37. M. Wakui, Y. Yokoyama, and H. Wang Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers J Cancer Res Clin Oncol 136 2010 1143
38. M. Loning, H. Diddens, and W. Kupker Laparoscopic fluorescence detection of ovarian carcinoma metastases using 5-aminolevulinic acid-induced protoporphyrin IX Cancer 100 2004 1650
39. A.A. Barnett, J.C. Haller, and F. Cairnduff A randomised, double-blind, placebo-controlled trial of photodynamic therapy using 5-aminolaevulinic acid for the treatment of cervical intraepithelial neoplasia Int J Cancer 103 2003 829
40. P. Soergel, X. Wang, and H. Stepp Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate Lasers Surg Med 40 2008 611
41. P. Soergel, and P. Hillemanns Photodynamic therapy for intraepithelial neoplasia of the lower genital tract Photodiagnosis Photodyn Ther 7 2010 10
42. W.F. Mourad, J. Dutcher, and R.D. Ennis State-of-the-art management of renal cell carcinoma Am J Clin Oncol 2012 in press
43. G. Popken, U. Wetterauer, and W. Schultze-Seemann Kidney-preserving tumour resection in renal cell carcinoma with photodynamic detection by 5-aminolaevulinic acid: preclinical and preliminary clinical results BJU Int 83 1999 578
44. M.R. Hoda, and G. Popken Surgical outcomes of fluorescence-guided laparoscopic partial nephrectomy using 5-aminolevulinic acid-induced protoporphyrin IX J Surg Res 154 2009 220
45. S.J. Madsen, K. Kharkhuu, and H. Hirschberg Utility of the F98 rat glioma model for photodynamic therapy J Environ Pathol Toxicol Oncol 26 2007 149
46. G. von Campe, M. Moschopulos, and M. Hefti 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence as immediate intraoperative indicator to improve the safety of malignant or high-grade brain tumor diagnosis in frameless stereotactic biopsies Acta Neurochir (Wien) 154 2012 585 discussion 588
47. M.S. Eljamel, C. Goodman, and H. Moseley ALA and Photofrin fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial Lasers Med Sci 23 2008 361
48. W. Stummer, A. Novotny, and H. Stepp Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients J Neurosurg 93 2000 1003
49. W. Stummer, U. Pichlmeier, and T. Meinel Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial Lancet Oncol 7 2006 392
50. W. Stummer, S. Stocker, and S. Wagner Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence Neurosurgery 42 1998 518 discussion 525
51. H. Stepp, T. Beck, and T. Pongratz ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment J Environ Pathol Toxicol Oncol 26 2007 157
52. A. Johansson, G. Palte, and O. Schnell 5-Aminolevulinic acid-induced protoporphyrin IX levels in tissue of human malignant brain tumors Photochem Photobiol 86 2010 1373
53. C. Ewelt, W. Stummer, and B. Klink Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection Clin Neurol Neurosurg 112 2010 357
54. Y. Kajimoto, T. Kuroiwa, and S. Miyatake Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence. Case report J Neurosurg 106 2007 1070
55. W. Stummer, T. Beck, and W. Beyer Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report J Neurooncol 87 2008 103
56. D.L. Campbell, E.F. Gudgin-Dickson, and P.G. Forkert Detection of early stages of carcinogenesis in adenomas of murine lung by 5-aminolevulinic acid-induced protoporphyrin IX fluorescence Photochem Photobiol 64 1996 676
57. J.C. Kennedy, and R.H. Pottier Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy J Photochem Photobiol B Biol 14 1992 275
58. A.H. Ali, H. Takizawa, and K. Kondo 5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor Lung Cancer 74 2011 48
59. W.J. Piotrowski, J. Marczak, and A. Nawrocka Inhalations of 5-ALA in photodynamic diagnosis of bronchial cancer Monaldi Arch Chest Dis 61 2004 86
60. S. Lam Photodynamic therapy of lung cancer Semin Oncol 21 1994 15
61. A. Maier, F. Tomaselli, and V. Matzi Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study Lasers Surg Med 30 2002 12
62. P.E. Claydon, and R. Ackroyd 5-Aminolaevulinic acid-induced photodynamic therapy and photodetection in Barrett's esophagus Dis Esophagus 17 2004 205
63. M. Hage, P.D. Siersema, and H. van Dekken 5-Aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett's oesophagus: a randomised trial Gut 53 2004 785
64. P. Hinnen, F.W. de Rooij, and W.C. Hop Timing of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of patients with Barrett's oesophagus J Photochem Photobiol B 68 2002 8
65. R. Ackroyd, N.J. Brown, and M.F. Davis Photodynamic therapy for dysplastic Barrett's oesophagus: a prospective, double blind, randomised, placebo controlled trial Gut 47 2000 612
66. R. Ackroyd, C.J. Kelty, and N.J. Brown Eradication of dysplastic Barrett's oesophagus using photodynamic therapy: long-term follow-up Endoscopy 35 2003 496
67. I.A. Boere, D.J. Robinson, and H.S. de Bruijn Protoporphyrin IX fluorescence photobleaching and the response of rat Barrett's esophagus following 5-aminolevulinic acid photodynamic therapy Photochem Photobiol 82 2006 1638
68. B. Mayinger, S. Neidhardt, and H. Reh Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions Gastrointest Endosc 54 2001 572
69. F. Peters, M. Kara, and W. Rosmolen Poor results of 5-aminolevulinic acid-photodynamic therapy for residual high-grade dysplasia and early cancer in barrett esophagus after endoscopic resection Endoscopy 37 2005 418
70. G.D. Mackenzie, J.M. Dunn, and C.R. Selvasekar Optimal conditions for successful ablation of high-grade dysplasia in Barrett's oesophagus using aminolaevulinic acid photodynamic therapy Lasers Med Sci 24 2009 729
71. T. Rabenstein, A. May, and L. Gossner Invisible gastric carcinoma detected by random biopsy: long-term results after photodynamic therapy Endoscopy 40 2008 899
72. J. Smolka, A. Mateasik, and B. Cunderlikova In vivo fluorescence diagnostics and photodynamic therapy of gastrointestinal superficial polyps with aminolevulinic acid. A clinical and spectroscopic study Neoplasma 53 2006 418
73. B.W. McIlroy, A. Curnow, G. Buonaccorsi, M.A. Scott, S.G. Bown, and A.J. MacRobert Spatial measurement of oxygen levels during photodynamic therapy using time-resolved optical spectroscopy J Photochem Photobiol B 43 1998 47
74. C.M. Yow, C.K. Wong, Z. Huang, and R.J. Ho Study of the efficacy and mechanism of ALA-mediated photodynamic therapy on human hepatocellular carcinoma cell Liver Int 27 2007 201
75. F. Bergmann, H. Stepp, and R. Metzger In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results Pediatr Surg Int 24 2008 1331
76. H.C. Wolfsen Photodynamic therapy for pancreatic cancer: let's get serious Gastrointest Endosc 67 2008 961
77. A. Hajri, S. Coffy, and F. Vallat Human pancreatic carcinoma cells are sensitive to photodynamic therapy in vitro and in vivo Br J Surg 86 1999 899
78. P. Mikvy, H. Messman, and A.J. MacRobert Photodynamic therapy of a transplanted pancreatic cancer model using meta-tetrahydroxyphenylchlorin (mTHPC) Br J Cancer 76 1997 713
79. S.G. Bown, A.Z. Rogowska, and D.E. Whitelaw Photodynamic therapy for cancer of the pancreas Gut 50 2002 549
80. K.S. Samkoe, A. Chen, and I. Rizvi Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models Int J Radiat Oncol Biol Phys 76 2010 251
81. D. Fayter, M. Corbett, and M. Heirs A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions, Barrett's oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin Health Technol Assess 14 2010 1
82. T. Zoepf, R. Jakobs, and A. Rosenbaum Photodynamic therapy with 5-aminolevulinic acid is not effective in bile duct cancer Gastrointest Endosc 54 2001 763
83. S. Pereira Photodynamic therapy for pancreatic and biliary tract cancer: the United Kingdom experience J Natl Compr Canc Netw 10 Suppl 2 2012 S48
84. R.W. Wu, E.S. Chu, and C.M. Yow Photodynamic effects on nasopharyngeal carcinoma (NPC) cells with 5-aminolevulinic acid or its hexyl ester Cancer Lett 242 2006 112
85. C.S. Betz, J.P. Lai, and W. Xiang In vitro photodynamic therapy of nasopharyngeal carcinoma using 5-aminolevulinic acid Photochem Photobiol Sci 1 2002 315
86. W.E. Grant, C. Hopper, and A.J. MacRobert Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid Lancet 342 1993 147
87. K.F. Fan, C. Hopper, and P.M. Speight Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity Cancer 78 1996 1374
88. M.A. Biel Photodynamic therapy of head and neck cancers Methods Mol Biol 635 2010 281
89. F. Civantos Photodynamic therapy for head and neck lesions in the subtropics J Natl Compr Canc Netw 10 Suppl 2 2012 S65
90. M. Biel Advances in photodynamic therapy for the treatment of head and neck cancers Lasers Surg Med 38 2006 349
91. L.B. Li, R.C. Luo, and W.J. Liao [Clinical study of Photofrin photodynamic therapy for advanced cancers] Di Yi Jun Yi Da Xue Xue Bao 23 2003 1341
92. A. Sharwani, W. Jerjes, and C. Hopper Photodynamic therapy down-regulates the invasion promoting factors in human oral cancer Arch Oral Biol 51 2006 1104
93. S. Yanase, J. Nomura, and Y. Matsumura Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model Int J Oncol 29 2006 365
94. S.K. Bisland, C. Chien, and B.C. Wilson Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis Photochem Photobiol Sci 5 2006 31