Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies

British Journal of Cancer

Volumn 90, Issue 8, 2004, Pages 1660-1665

  Perotti, C ^a   Fukuda, H ^a   DiVenosa, G ^a   MacRobert, A J ^b   Batlle, A ^a,c   Casas, A ^a  

^a Ciudad Universitaria   (Argentina)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c Viamonte 1881 10A   (Argentina)

Author keywords

ALA; ALA derivatives; Aminolevulinic acid; PDT; Photodynamic therapy

Indexed keywords

2 (HYDROXYMETHYL)TETRAHYDROPYRANYL 5 AMINOLEVULINIC ACID; AMINOLEVULINIC ACID; HEXYL 5 AMINOLEVULINIC ACID; PHOTOSENSITIZING AGENT; PORPHYRIN; UNCLASSIFIED DRUG; UNDECANOYL 5 AMINOLEVULINIC ACID; DRUG DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BREAST TUMOR; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG EFFICACY; DRUG UPTAKE; EXPLANT; ION EXCHANGE CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PORPHYRIN METABOLISM; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; EXPERIMENTAL NEOPLASM; METHODOLOGY; PHOTOCHEMOTHERAPY;

AMINOLEVULINIC ACID; ANIMALS; MALE; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS;

EID: 2442614764     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601722     Document Type: Article

References (23)

1. Batlle A (1997) Porfirias y Porfirinas. Aspectos clínicos, bioquímicos y biología molecular. Buenos Aires, Argentina: ED: Acta Bioquímica Clinica Latinoamericana,
2. Baumgartner R, Huber R, Schulz H, Stepp H, Rick K, Gamarra F, Leberig A, Roth C (1996) Inhalation of 5-aminolevulinic acid: a new technique for fluorescence detection of early stage lung cancer. J. Photochem. Photobiol. B 36: 167-174
3. Bermúdez Moretti M, Correa García S, Perotti C, Batlle A, Casas A (2002) 5-aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters. Br. J. Cancer 87: 471-474
4. Casas A, Batlle A (2002) Rational design of 5-aminolevulinic acid derivatives aimed at improving photodynamic therapy. Curr Med. Chem. Anti-Cancer Agents 2: 465-475
5. Casas A, Fukuda H, Di Venosa G, Batlle A (2001a) Photosensitisation and mechanism of cytotoxicity induced by the use of ALA derivatives in photodynamic therapy. Br J Cancer 85: 279-284
6. Casas A, Perotti C, Fukuda H, Rogers L, Butler A, Batlle A (2001b) ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitisation. Br J Cancer 85: 1740-1800
7. Denizot F, Lang R (1986) Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89: 271-277
8. Di Venosa G, Fukuda H, Perotti C, Batlle A, Casas A (2003) A simple method for separating ALA from ALA derivatives using ionic exchange chromatography. J Photochem Photobiol B, (submitted)
9. Eléouet S, Rousset N, Carré J, Bourré L, Vonarx V, Lajat Y, Beijersbergen van Henegouwen G, Patrice T (2000) In vitro fluorescence, toxicity and phototoxicity induced by 5-aminolevulinic acid (ALA) or ALA-esters. Photochem Photobiol 71: 447-454
10. Fukuda H, Paredes S, Batlle A (1989) Tumour-localizing properties of porphyrins. In vitro studies using the porphyrin precursor, aminolevulinic acid, in free and liposome encapsulated forms. Drug Des Deliv 6: 133-139
11. Fukuda H, Paredes S, Batlle A (1992) Tumour-localizing properties of porphyrins. In vivo studies using free and liposome encapsulated aminolevulinic acid. Comp Biochem Physiol 102B: 433-436
12. Hilf R, Smail D, Murant R, Leakey P, Gibson S (1984) Hematoporphyrin derivative induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats. Cancer Res 44: 1483-1488
13. Kennedy J, Pottier R, Pross G (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B 6: 143-148
14. Kloek J, Akkermans W, Beijersbergen van Henegouwen G (1998) Derivatives of 5-aminolevulinic acid for photodynamic therapy: enzymatic conversion into protoporphyrin. Photochem Photobiol 67: 150-154
15. Krieg R, Uihlein D, Murthum T, Endlicher E, Hausmann F, Messmann H, Knuechel R (2002) Improving the use of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PPIX) for the gastrointestinal tract by esterification - an in vitro study. Cell Mol Biol 48: 917-923
16. Mauzerall M, Granick S (1956) The occurrence and determination of 5-aminolevulinic acid and porphobilinogen in urine. J Biol Chem 219: 435-437
17. Peng Q, Warloe T, Moan J, Heyerdahl H, Steen H, Giercksky K, Nesland J (1995) ALA derivative-induced protoporphyrin IX build-up and distribution in human nodular basal cell carcinoma. Photochem Photobiol 61: 82S
18. Perotti C, Casas A, Fukuda H, Sacca P, Batlle A (2002) ALA and ALA hexyl ester induction of porphyrins after their systemic administration to tumour bearing mice. Br J Cancer 87: 790-795
19. Polo CF, Navone NM, Afonso SG, Vazquez ES, Buzaleh AM, Bianchi A, Schoua E, Batlle A (1988) Induction of porphyrin biosynthesis in tissue explants and the effect of antimitotics. ATLA 16: 137-147
20. Takeya H (1992) Preparation of 5-aminolevulinic acid alkyl esters as herbicides. Chem Abstr 116: 189633 m
21. Werbajh SE, Urtreger AJ, Puricelli LI, de Lustig ES, Bal de Kier Joffe E, Kornblihtt AR (1998) Downregulation of fibronectin transcription in highly metastatic adenocarcinoma cells. FEBS Lett 440: 277-281
22. Whitaker C, Battah S, Forsyth M, Edwards C, Boyle R, Matthews K (2000) Photosensitization of pancreatic tumour cells by 5-aminolevulinic acid esters. Anti-Cancer Drugs Des 15: 161-170
23. Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T, Wallace J (1998) United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the welfare of animals in experimental neoplasia (Second Edition). Br J Cancer 77: 1-10