Scoparone attenuates d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure through inhibition of toll-like receptor 4 signaling in mice

Food and Chemical Toxicology

Volumn 57, Issue , 2013, Pages 132-139

  Kang, Jung Woo ^a   Kim, Dong Wook ^a   Choi, Jae Sue ^b   Kim, Yeong Shik ^c   Lee, Sun Mee ^a  

^a Sungkyunkwan University   (South Korea)

^b Pukyong National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

D Galactosamine lipopolysaccharide; Fulminant hepatic failure; Inflammation; Myeloid differentiation primary response gene 88; Toll like receptor 4; Toll receptor associated activator of interferon

Indexed keywords

ALANINE AMINOTRANSFERASE; BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; SCOPARONE; SILYMARIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; FULMINANT HEPATIC FAILURE; IMMUNOMODULATION; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ALANINE TRANSAMINASE; ANIMALS; ARTEMISIA; COUMARINS; GALACTOSAMINE; HEPATOCYTES; INTERFERON-BETA; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LIVER FAILURE, ACUTE; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84876401156     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.03.016     Document Type: Article

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