Vitamin C supplementation does not improve hypoxia-induced erythropoiesis

High Altitude Medicine and Biology

Volumn 13, Issue 4, 2012, Pages 269-274

  Martinez Bello, Vladimir E ^a   Sanchis Gomar, Fabian ^a   Martinez Bello, Daniel ^b   Olaso Gonzalez, Gloria ^a   Gomez Cabrera, Mari Carmen ^a   Viña, Jose ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSIDAD COOPERATIVA DE COLOMBIA   (Colombia)

Author keywords

antioxidants; hematocrit; hemoglobin; oxidative stress; red blood cells

Indexed keywords

ASCORBIC ACID; ERYTHROPOIETIN; HEMOGLOBIN; MALONALDEHYDE;

ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE COUNT; ERYTHROPOIESIS; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; INTERMITTENT HYPOXIA; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; RETICULOCYTE; VITAMIN SUPPLEMENTATION;

ANIMALS; ANOXIA; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL MARKERS; BLOOD PROTEINS; DIETARY SUPPLEMENTS; DRUG ADMINISTRATION SCHEDULE; ERYTHROPOIESIS; HEMATOLOGIC TESTS; MALE; MALONDIALDEHYDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 84876392673     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2012.1028     Document Type: Article

References (28)

1. Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, and Gleadle JM. (2004). Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279:38458-38465. (Pubitemid 39295997)
2. Asha Devi S, Subramanyam MV, Vani R, and Jeevaratnam K. (2005). Adaptations of the antioxidant system in erythrocytes of trained adult rats: Impact of intermittent hypobaric-hypoxia at two altitudes. Comp Biochem Physiol C Toxicol Pharmacol 140:59-67. (Pubitemid 40409880)
3. Berger TM, Polidori MC, Dabbagh A, Evans PJ, Halliwell B, Morrow JD, Roberts LJ, 2nd, and Frei B. (1997). Antioxidant activity of vitamin C in iron-overloaded human plasma. J Biol Chem 272:15656-15660. (Pubitemid 27265535)
4. Chao WH, Askew EW, Roberts DE, Wood SM, and Perkins JB. (1999). Oxidative stress in humans during work at moderate altitude. J Nutr 129:2009-2012. (Pubitemid 29506378)
5. Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwenburgh C. (2001). Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radic Biol Med 31: 745-753. (Pubitemid 32835255)
6. Devi SA, Vani R, Subramanyam MV, Reddy SS, and Jeevaratnam K. (2007). Intermittent hypobaric hypoxia-induced oxidative stress in rat erythrocytes: Protective effects of vitamin E, vitamin C, and carnitine. Cell Biochem Funct 25:221-231. (Pubitemid 46408658)
7. Esteva S, Pedret R, Fort N, Torrella JR, Pages T, and Viscor G. (2010). Oxidative stress status in rats after intermittent exposure to hypobaric hypoxia. Wilderness Environ Med 21:325-331.
8. Garcia JF. (1957). Erythropoietic response to hypoxia as a function of age in the normal male rat. Am J Physiol 190:25-30.
9. Keven K, Kutlay S, Nergizoglu G, and Erturk S. (2003). Randomized, crossover study of the effect of vitamin C on EPO response in hemodialysis patients. Am J Kidney Dis 41:1233-1239. (Pubitemid 36637979)
10. Lack JA and Stuart-Taylor ME. (1997). Calculation of drug dosage and body surface area of children. Br J Anaesth 78:601-605. (Pubitemid 27226380)
11. Lappin T and Masson N. (2011). Two antioxidants are better than one. Blood 117:5276-5277.
12. Levine BD and Stray-Gundersen J. (2005). Point: Positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume. J Appl Physiol 99:2053-2055. (Pubitemid 41547209)
13. Li SH, Ryu JH, Park SE, Cho YS, Park JW, Lee WJ, and Chun YS. (2010). Vitamin C supplementation prevents testosterone-induced hyperplasia of rat prostate by down-regulating HIF-1alpha. J Nutr Biochem 21:801-808.
14. Maeda N, Hagihara H, Nakata Y, Hiller S, Wilder J, and Reddick R. (2000). Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci USA 97:841-846. (Pubitemid 30070397)
15. Martinez-Bello VE, Sanchis-Gomar F, Nascimento AL, Pallardo FV, Ibanez-Sania S, Olaso-Gonzalez G, Calbet JA, Gomez-Cabrera MC, and Vina J. (2011). Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats. Eur J Appl Physiol 111:1147-1156.
16. Nagata M, Arimitsu N, Ito T, and Sekimizu K. (2007). Antioxidant N-acetyl-L-cysteine inhibits erythropoietin-induced differentiation of erythroid progenitors derived from mouse fetal liver. Cell Biol Int 31:252-256. (Pubitemid 46275480)
17. Nytko KJ, Maeda N, Schlafli P, Spielmann P, Wenger RH, and Stiehl DP. (2011). Vitamin C is dispensable for oxygen sensing in vivo. Blood 117:5485-5493.
18. Pialoux V, Brugniaux JV, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Clottes E, Coudert J, Fellmann N, and Mounier R. (2010). Antioxidant status of elite athletes remains impaired 2 weeks after a simulated altitude training camp. Eur J Nutr 49:285-292.
19. Pialoux V, Mounier R, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Brugniaux J, Coudert J, and Fellmann N. (2009). Effects of the 'live high-train low' method on prooxidant/antioxidant balance on elite athletes. Eur J Clin Nutr 63: 756-762.
20. Radak Z, Asano K, Lee KC, Ohno H, Nakamura A, Nakamoto H, and Goto S. (1997). High altitude training increases reactive carbonyl derivatives but not lipid peroxidation in skeletal muscle of rats. Free Radic Biol Med 22:1109-1114. (Pubitemid 27084147)
21. Reagan-Shaw S, Nihal M, and Ahmad N. (2008). Dose translation from animal to human studies revisited. FASEB J 22: 659-661. (Pubitemid 351348146)
22. Romagnoli M, Gomez-Cabrera MC, Perrelli MG, Biasi F, Pallardo FV, Sastre J, Poli G, and Vina J. (2010). Xanthine oxidaseinduced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats. Free Radic Biol Med 49:171-177.
23. Sanchis-Gomar F, Martinez-Bello VE, Domenech E, Nascimento AL, Pallardo FV, Gomez-Cabrera MC, and Vina J. (2009). Effect of intermittent hypoxia on hematological parameters after recombinant human erythropoietin administration. Eur J Appl Physiol 107:429-436.
24. Sobal J and Marquart LF. (1994.) Vitamin/mineral supplement use among athletes: A review of the literature. Int J Sport Nutr 4:320-334.
25. Tarng DC. (2007). Novel aspects of vitamin C in epoetin response. J Chin Med Assoc 70:357-360.
26. Vani R, Reddy CS, and Asha Devi S. (2010). Oxidative stress in erythrocytes: A study on the effect of antioxidant mixtures during intermittent exposures to high altitude. Int J Biometeorol 54:553-562.
27. Wong SH, Knight JA, Hopfer SM, Zaharia O, Leach CN, Jr., and Sunderman FW, Jr. (1987). Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33:214-220. (Pubitemid 17161121)
28. Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski Z, and Szyszka K. (2010). Modulatory effect of N-acetylcysteine on pro-antioxidant status and haematological response in healthy men. J Physiol Biochem 66:15-21.