VP22 and cytosine deaminase fusion gene modified tissue-engineered neural stem cells for glioma therapy

Journal of Cancer Research and Clinical Oncology

Volumn 139, Issue 3, 2013, Pages 475-483

  Jin, Guishan ^a   Zhou, Yiqiang ^a   Chai, Qi ^a   Zhu, Guidong ^a   Xu, Fujian ^b   Liu, Fusheng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

C6 glioma; Cytosine deaminase; Gene therapy; Neural stem cells; VP22 shuttle protein

Indexed keywords

CYTOSINE DEAMINASE; ENHANCED GREEN FLUORESCENT PROTEIN; FLUCYTOSINE; LENTIVIRUS VECTOR; PROTEIN VP22; VIRUS ENZYME; HERPES SIMPLEX VIRUS TYPE 1 PROTEIN VP22; HYBRID PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GENE THERAPY; CANCER SIZE; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CYTOSINE DEAMINASE GENE; EMBRYO; FUSION GENE; GLIOMA; HUMAN IMMUNODEFICIENCY VIRUS; IN VIVO STUDY; MALE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUICIDE GENE; SURVIVAL RATE; TISSUE ENGINEERING; VP22 GENE; ANIMAL; ANIMAL EMBRYO; BRAIN TUMOR; CELL CULTURE; EVALUATION; GENE THERAPY; GENE TRANSFER; GENETICS; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSPLANTATION;

ANIMALS; BRAIN NEOPLASMS; CELLS, CULTURED; CYTOSINE DEAMINASE; EMBRYO, MAMMALIAN; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GLIOMA; HUMANS; MALE; NEURAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; TISSUE ENGINEERING; VIRAL STRUCTURAL PROTEINS;

MLCS; MLOWN;

EID: 84876331166     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1347-3     Document Type: Article

References (30)

1. Aboody KS, Najbauer J, Danks MK (2008) Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther 15:739-752
2. Ahmed AU, Lesniak MS (2011) Glioblastoma multiforme: can neural stem cells deliver the therapeutic payload and fulfill the clinical promise? Expert Rev Neurother 11:775-777
3. Barresi V, Belluardo N, Sipione S, Mudo G, Cattaneo E, Condorelli DF (2003) Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy. Cancer Gene Ther 10:396-402
4. Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, Rigamonti D, Galli R, Selleri S, Di Meco F, De Fraja C, Vescovi A, Cattaneo E, Finocchiaro G (2000) Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6:447-450
5. Binello E, Germano IM (2012) Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol 14:256-265
6. Elliott G, O'Hare P (1997) Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223-233
7. Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL, Abraham GN (1993) The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53:5274-5283
8. Glass R, Synowitz M, Kronenberg G, Walzlein JH, Markovic DS, Wang LP, Gast D, Kiwit J, Kempermann G, Kettenmann H (2005) Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J Neurosci 25:2637-2646
9. Huber BE, Austin EA, Richards CA, Davis ST, Good SS (1994) Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Natl Acad Sci USA 91:8302-8306
10. Jin GS, Liu FS, Chai Q, Wang JJ, Li JH (2008) Stable EGFP gene expression in C6 glioma cell line after transduction with HIV-1-based lentiviral vector. Chin J Cancer Res 20:243-248
11. Kretz A, Wybranietz WA, Hermening S, Lauer UM, Isenmann S (2003) HSV-1 VP22 augments adenoviral gene transfer to CNS neurons in the retina and striatum in vivo. Mol Ther 7:659-669
12. Lai Z, Han I, Zirzow G, Brady RO, Reiser J (2000) Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors. Proc Natl Acad Sci USA 97:11297-11302
13. Lee KC, Hamstra DA, Bullarayasamudram S, Bhojani MS, Moffat BA, Dornfeld KJ, Ross BD, Rehemtulla A (2006) Fusion of the HSV-1 tegument protein vp22 to cytosine deaminase confers enhanced bystander effect and increased therapeutic benefit. Gene Ther 13:127-137
14. Lefranc F, Brotchi J, Kiss R (2005) Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J Clin Oncol 23:2411-2422
15. Liu CS, Kong B, Xia HH, Ellem KA, Wei MQ (2001) VP22 enhanced intercellular trafficking of HSV thymidine kinase reduced the level of ganciclovir needed to cause suicide cell death. J Gene Med 3:145-152
16. Lobanov VA, Zheng C, Babiuk LA, van Drunen LDHS (2010) Intracellular trafficking of VP22 in bovine herpesvirus-1 infected cells. Virology 396:189-202
17. Naito S, von Eschenbach AC, Giavazzi R, Fidler IJ (1986) Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res 46:4109-4115
18. Oh MC, Lim DA (2009) Novel treatment strategies for malignant gliomas using neural stem cells. Neurotherapeutics 6:458-464
19. Phelan A, Elliott G, O'Hare P (1998) Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nat Biotechnol 16:440-443
20. Ricard D, Idbaih A, Ducray F, Lahutte M, Hoang-Xuan K, Delattre JY (2012) Primary brain tumours in adults. Lancet 379:1984-1996
21. Sathornsumetee S, Rich JN (2008) Designer therapies for glioblastoma multiforme. Ann NY Acad Sci 1142:108-132
22. Tabatabai G, Wick W, Weller M (2011) Stem cell-mediated gene therapies for malignant gliomas: a promising targeted therapeutic approach? Discov Med 11:529-536
23. Tanaka M, Kato A, Satoh Y, Ide T, Sagou K, Kimura K, Hasegawa H, Kawaguchi Y (2012) Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence. J Virol 86:5264-5277
24. Thaci B, Ahmed AU, Ulasov IV, Tobias AL, Han Y, Aboody KS, Lesniak MS (2012) Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model. Cancer Gene Ther 19:431-442
25. Ubiali F, Nava S, Nessi V, Frigerio S, Parati E, Bernasconi P, Mantegazza R, Baggi F (2007) Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation. Int Immunol 19:1063-1074
26. Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492-507
27. Wybranietz WA, Prinz F, Spiegel M, Schenk A, Bitzer M, Gregor M, Lauer UM (1999) Quantification of VP22-GFP spread by direct fluorescence in 15 commonly used cell lines. J Gene Med 1:265-274
28. Yazawa K, Fisher WE, Brunicardi FC (2002) Current progress in suicide gene therapy for cancer. World J Surg 26:783-789
29. Yuan X, Hu J, Belladonna ML, Black KL, Yu JS (2006) Interleukin-23- expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma. Cancer Res 66:2630-2638
30. Zavaglia D, Favrot MC, Eymin B, Tenaud C, Coll JL (2003) Intercellular trafficking and enhanced in vivo antitumour activity of a non-virally delivered P27-VP22 fusion protein. Gene Ther 10:314-325