Structure of a NHEJ polymerase-mediated DNA synaptic complex

Science

Volumn 318, Issue 5849, 2007, Pages 456-459

  Brissett, Nigel C ^a   Pitcher, Robert S ^a   Juarez, Raquel ^b   Picher, Angel J ^b   Green, Andrew J ^a   Dafforn, Timothy R ^c   Fox, Gavin C ^d   Blanco, Luis ^b   Doherty, Aidan J ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DOUBLE STRANDED DNA; LYSINE;

DNA; GENOME; POLYMERASE CHAIN REACTION; PROKARYOTE; PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; DNA STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NON HOMOLOGOUS END JOINING; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SYNAPSE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA LIGASES; DNA REPAIR; DNA, BACTERIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

MYCOBACTERIUM TUBERCULOSIS; PROKARYOTA; SYNAPSIS;

EID: 35349028355     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145112     Document Type: Article

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23. We thank T. Brown, A. Lebedev, M. Osbourne, and D. Thompson for technical advice and support; T. Wilson for valuable comments on the manuscript; and the European Synchrotron Radiation Facility for provision of synchrotron radiation facilities. Work in A.J.D.'s laboratory is supported by grants from the UK Biotechnology and Biological Sciences Research Council, Cancer Research UK, the Association for International Cancer Research, and the Royal Society. Work in L.B.'s laboratory was supported by Ministerio de Ciencia y Tecnología grant BMC 2003-00186, Consolider CSD2007-00015, and an institutional grant to Centro de Biología Molecular Severo Ochoa from Fundación Ramón Areces. A.J.P. is a recipient of a fellowship from the Spanish Ministry of Science and Technology.