A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: Application to pharmacokinetic study

Biomedical Chromatography

Volumn 27, Issue 5, 2013, Pages 676-680

  Yun, Fei ^a   Kang, An ^a   Shan, Jinjun ^a   Zhao, Xiaoli ^a   Bi, Xiaolin ^a   Di, Liuqing ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

LC MS MS; Osthole; Pharmacokinetics; Rat plasma

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; EXTRACTION; MEDICINE; RATS;

ETHYL-ACETATE; LC-MS-MS; LC.MS/MS; LIQUID-LIQUID EXTRACTION; OSTHOLE; PHARMACOKINETIC STUDIES; RAT PLASMA; SAMPLE PREPARATION; SIMPLE LIQUIDS; TRADITIONAL CHINESE MEDICINE;

PHARMACOKINETICS;

ACETIC ACID ETHYL ESTER; OSTHOLE; PENTOSALEN;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CHEMICAL STRUCTURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; NONHUMAN; QUALITY CONTROL; RAT;

CNIDIUM MONNIERI; RATTUS;

EID: 84876302203     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2850     Document Type: Article

References (20)

1. Chen T, Liu W, Chao X, Qu Y, Zhang L, Luo P, Xie K, Huo J and Fei Z. Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway. Neuroscience 2011; 183: 203-211.
2. Dien PH, Nhan NT, Le Thuy HT and Quang DN. Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity. Natural Product Research 2012; 26: 2107-2111.
3. Food and Drug Administration. Guidance for Industry - Bioanalytical Method Validation. US Department of Health and Human Services, CDER and CVM: Rockville, MD, 2001.
4. He Y, Qu S, Wang J, He X, Lin W, Zhen H and Zhang X. Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats. Brain Research 2012; 1433: 127-136.
5. Hsieh MT, Hsieh CL, Wang WH, Chen CS, Lin CJ and Wu CR. Osthole improves aspects of spatial performance in ovariectomized rats. The American Journal of Chinese Medicine 2004; 32: 11-20.
6. Hung CM, Kuo DH, Chou CH, Su YC, Ho CT and Way TD. Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells. Journal of Agriculture and Food Chemistry 2011; 59: 9683-9690.
7. Li Y, Meng F, Xiong Z, Liu H and Li F. HPLC determination and pharmacokinetics of osthole in rat plasma after oral administration of Fructus Cnidii extract. Journal of Chromatographic Science 2005; 43: 426-429.
8. Liao PC, Chien SC, Ho CL, Wang EI, Lee SC, Kuo YH, Jeyashoke N, Chen J, Dong WC, Chao LK and Hua KF. Osthole regulates inflammatory mediator expression through modulating NF-kappaB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species. Journal of Agriculture and Food Chemistry 2010; 58: 10445-10451.
9. Liu M, Liu H, Lu X, Li C, Xiong Z and Li F. Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS. Journal of Chromatography B: Analytical Technology in Biomedicine and Life Sciences 2007; 860: 113-120.
10. Liu M, Liu HP, Lu XM, Xiong ZL and Li FM. Analysis of the compounds present in rat blood after oral administration of the extract of Gushudan (a Chinese compound prescription). Asian Journal of Traditional Medicines 2008; 3: 24-32.
11. Matsuda H, Tomohiro N, Ido Y and Kubo M. Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biolaogical and Pharmaceutical Bulletin 2002; 25: 809-812.
12. Okamoto T, Kawasaki T and Hino O. Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway. Biochemical Pharmacology 2003; 65: 677-681.
13. Okamoto T, Kobayashi T and Yoshida S. Synthetic derivatives of osthole for the prevention of hepatitis. Medical Chemistry 2007; 3: 35-44.
14. Sun F, Xie ML, Xue J and Wang HB. Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine. Phytomedicine 2010; 17: 669-673.
15. Tsai TH, Tsai TR, Chen CC and Chen CF. Pharmacokinetics of osthole in rat plasma using high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 1996; 14: 749-753.
16. You L, Feng S, An R and Wang X. Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM). Natural Product Communications 2009; 4: 297-302.
17. Zhang J, Xue J, Wang H, Zhang Y and Xie M. Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. Phytotherapy Research 2011; 25: 638-643.
18. Zhang Q, Qin L, He W, Van Puyvelde L, Maes D, Adams A, Zheng H and De Kimpe N. Coumarins from Cnidium monnieri and their antiosteoporotic activity. Planta Medica 2007; 73: 13-19.
19. Zhou J, Wang SW and Sun XL. Determination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extraction. Analytica Chimica Acta 2008; 608: 158-164.
20. Zhou J, Zeng P, Cheng ZH, Liu J, Wang FQ and Qian RJ. Application of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasma. Journal of Chromatography B: Analytical Technology in Biomedicine and Life Sciences 2011; 879: 2304-2310.