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Volumn 63, Issue 1, 2013, Pages 17-26

Polymorphisms of the kappa opioid receptor and prodynorphin genes: HIV risk and HIV natural history

Author keywords

CD4 count; OPRK1; PDYN; polymorphism; SNP; viral load; WIHS

Indexed keywords

KAPPA OPIATE RECEPTOR;

EID: 84876295705     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318285cd0c     Document Type: Article
Times cited : (5)

References (50)
  • 1
    • 0037373707 scopus 로고    scopus 로고
    • Opioid G protein-coupled receptors: Signals at the crossroads of inflammation
    • Rogers TJ, Peterson PK. Opioid G protein-coupled receptors: signals at the crossroads of inflammation. Trends Immunol. 2003;24:116-121.
    • (2003) Trends Immunol. , vol.24 , pp. 116-121
    • Rogers, T.J.1    Peterson, P.K.2
  • 2
    • 0037466528 scopus 로고    scopus 로고
    • Mu-opioid modulation of HIV-1 coreceptor expression and HIV-1 replication
    • Steele AD, Henderson EE, Rogers TJ. Mu-opioid modulation of HIV-1 coreceptor expression and HIV-1 replication. Virology. 2003;309: 99-107.
    • (2003) Virology. , vol.309 , pp. 99-107
    • Steele, A.D.1    Henderson, E.E.2    Rogers, T.J.3
  • 3
    • 0031874343 scopus 로고    scopus 로고
    • Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression
    • Mummidi S, Ahuja SS, Gonzalez E, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med. 1998;4:786-793.
    • (1998) Nat Med. , vol.4 , pp. 786-793
    • Mummidi, S.1    Ahuja, S.S.2    Gonzalez, E.3
  • 4
    • 0030861904 scopus 로고    scopus 로고
    • Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study
    • Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997;277: 959-965.
    • (1997) Science. , vol.277 , pp. 959-965
    • Smith, M.W.1    Dean, M.2    Carrington, M.3
  • 5
    • 0006582115 scopus 로고    scopus 로고
    • Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
    • Kaslow RA, Carrington M, Apple R, et al. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med. 1996;2:405-411.
    • (1996) Nat Med. , vol.2 , pp. 405-411
    • Kaslow, R.A.1    Carrington, M.2    Apple, R.3
  • 6
    • 0033502040 scopus 로고    scopus 로고
    • Consistent associations of HLA class i and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men
    • Keet IP, Tang J, Klein MR, et al. Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men. J Infect Dis. 1999;180:299-309.
    • (1999) J Infect Dis. , vol.180 , pp. 299-309
    • Keet, I.P.1    Tang, J.2    Klein, M.R.3
  • 7
    • 34548134145 scopus 로고    scopus 로고
    • A whole-genome association study of major determinants for host control of HIV-1
    • Fellay J, Shianna KV, Ge D, et al. A whole-genome association study of major determinants for host control of HIV-1. Science. 2007;317: 944-947.
    • (2007) Science. , vol.317 , pp. 944-947
    • Fellay, J.1    Shianna, K.V.2    Ge, D.3
  • 8
    • 77950229250 scopus 로고    scopus 로고
    • Host determinants of HIV-1 control in African Americans
    • Pelak K, Goldstein DB, Walley NM, et al. Host determinants of HIV-1 control in African Americans. J Infect Dis. 2010;201:1141-1149.
    • (2010) J Infect Dis. , vol.201 , pp. 1141-1149
    • Pelak, K.1    Goldstein, D.B.2    Walley, N.M.3
  • 9
    • 0022514668 scopus 로고
    • Antibody to LAV, the putative agent of AIDS, in parenteral drug abusers and methadone-maintained patients: Therapeutic, historical, and ethical aspects
    • Novick DM, Kreek MJ, Des Jarlais DC, et al. Antibody to LAV, the putative agent of AIDS, in parenteral drug abusers and methadone-maintained patients: therapeutic, historical, and ethical aspects. NIDA Res Monogr. 1986;67:318-320.
    • (1986) NIDA Res Monogr. , vol.67 , pp. 318-320
    • Novick, D.M.1    Kreek, M.J.2    Des Jarlais, D.C.3
  • 10
    • 0024314167 scopus 로고
    • Cocaine injection and ethnicity in parenteral drug users during the early years of the human immunodeficiency virus (HIV) epidemic in New York City
    • Novick DM, Trigg HL, Des Jarlais DC, et al. Cocaine injection and ethnicity in parenteral drug users during the early years of the human immunodeficiency virus (HIV) epidemic in New York City. J Med Virol. 1989;29:181-185.
    • (1989) J Med Virol. , vol.29 , pp. 181-185
    • Novick, D.M.1    Trigg, H.L.2    Des Jarlais, D.C.3
  • 11
    • 0024581966 scopus 로고
    • HIV-1 infection among intravenous drug users in Manhattan New York City from 1977 through 1987
    • Des Jarlais DC, Friedman SR, Novick DM, et al. HIV-1 infection among intravenous drug users in Manhattan, New York City, from 1977 through 1987. JAMA. 1989;261:1008-1012.
    • (1989) JAMA , vol.261 , pp. 1008-1012
    • Des Jarlais, D.C.1    Friedman, S.R.2    Novick, D.M.3
  • 12
    • 0025296063 scopus 로고
    • Contrasting prevalence of delta hepatitis markers in parenteral drug abusers with and without AIDS
    • Kreek MJ, Des Jarlais DC, Trepo CL, et al. Contrasting prevalence of delta hepatitis markers in parenteral drug abusers with and without AIDS. J Infect Dis. 1990;162:538-541.
    • (1990) J Infect Dis. , vol.162 , pp. 538-541
    • Kreek, M.J.1    Des Jarlais, D.C.2    Trepo, C.L.3
  • 13
    • 70349083000 scopus 로고    scopus 로고
    • Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception
    • Matsunaga M, Isowa T, Murakami H, et al. Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception. Brain Behav Immun. 2009;23: 931-935.
    • (2009) Brain Behav Immun. , vol.23 , pp. 931-935
    • Matsunaga, M.1    Isowa, T.2    Murakami, H.3
  • 14
    • 0031854313 scopus 로고    scopus 로고
    • Opiates transdeactivate chemokine receptors: Delta and mu opiate receptor-mediated heterolo-gous desensitization
    • Grimm MC, Ben-Baruch A, Taub DD, et al. Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterolo-gous desensitization. J Exp Med. 1998;188:317-325.
    • (1998) J Exp Med. , vol.188 , pp. 317-325
    • Grimm, M.C.1    Ben-Baruch, A.2    Taub, D.D.3
  • 15
    • 0033670372 scopus 로고    scopus 로고
    • Bidirectional heterologous desensitization of opioid and chemokine receptors
    • Rogers TJ, Steele AD, Howard OM, et al. Bidirectional heterologous desensitization of opioid and chemokine receptors. Ann N Y Acad Sci. 2000;917:19-28.
    • (2000) Ann N y Acad Sci. , vol.917 , pp. 19-28
    • Rogers, T.J.1    Steele, A.D.2    Howard, O.M.3
  • 16
    • 0036679172 scopus 로고    scopus 로고
    • Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain
    • Szabo I, Chen XH, Xin L, et al. Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci U S A. 2002;99:10276-10281.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , pp. 10276-10281
    • Szabo, I.1    Chen, X.H.2    Xin, L.3
  • 17
    • 0038645834 scopus 로고    scopus 로고
    • Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors
    • Zhang N, Hodge D, Rogers TJ, et al. Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors. J Biol Chem. 2003;278:12729-12736.
    • (2003) J Biol Chem. , vol.278 , pp. 12729-12736
    • Zhang, N.1    Hodge, D.2    Rogers, T.J.3
  • 18
    • 46649100868 scopus 로고    scopus 로고
    • Bi-directional heterologous desensi-tization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor
    • Finley MJ, Chen X, Bardi G, et al. Bi-directional heterologous desensi-tization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor. J Neuroimmunol. 2008;197:114-123.
    • (2008) J Neuroimmunol. , vol.197 , pp. 114-123
    • Finley, M.J.1    Chen, X.2    Bardi, G.3
  • 19
    • 28844445067 scopus 로고    scopus 로고
    • Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems
    • Zhang N, Oppenheim JJ. Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems. J Leukoc Biol. 2005;78: 1210-1214.
    • (2005) J Leukoc Biol. , vol.78 , pp. 1210-1214
    • Zhang, N.1    Oppenheim, J.J.2
  • 20
    • 79957982253 scopus 로고    scopus 로고
    • Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5
    • Song C, Rahim RT, Davey PC, et al. Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5. J Biol Chem. 2011;286:20354-20365.
    • (2011) J Biol Chem. , vol.286 , pp. 20354-20365
    • Song, C.1    Rahim, R.T.2    Davey, P.C.3
  • 21
    • 0025069797 scopus 로고
    • Beta-endorphin modulation of IL-1-induced IL-2 production
    • Bessler H, Sztein MB, Serrate SA. Beta-endorphin modulation of IL-1-induced IL-2 production. Immunopharmacology. 1990;19:5-14.
    • (1990) Immunopharmacology. , vol.19 , pp. 5-14
    • Bessler, H.1    Sztein, M.B.2    Serrate, S.A.3
  • 22
    • 0037087640 scopus 로고    scopus 로고
    • K-Opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4+ lymphocytes
    • Lokensgard JR, Gekker G, Peterson PK. k-Opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4+ lymphocytes. Biochem Pharmacol. 2002; 63:1037-1041.
    • (2002) Biochem Pharmacol. , vol.63 , pp. 1037-1041
    • Lokensgard, J.R.1    Gekker, G.2    Peterson, P.K.3
  • 23
    • 0035342409 scopus 로고    scopus 로고
    • Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes
    • Peterson PK, Gekker G, Lokensgard JR, et al. Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes. Biochem Pharmacol. 2001;61:1145-1151.
    • (2001) Biochem Pharmacol. , vol.61 , pp. 1145-1151
    • Peterson, P.K.1    Gekker, G.2    Lokensgard, J.R.3
  • 24
    • 2142659314 scopus 로고    scopus 로고
    • Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells
    • Gekker G, Hu S, Wentland MP, et al. Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. J Pharmacol Exp Ther. 2004;309:600-606.
    • (2004) J Pharmacol Exp Ther. , vol.309 , pp. 600-606
    • Gekker, G.1    Hu, S.2    Wentland, M.P.3
  • 25
    • 49849094871 scopus 로고    scopus 로고
    • Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women
    • Cook JA, Burke-Miller JK, Cohen MH, et al. Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women. AIDS. 2008;22:1355-1363.
    • (2008) AIDS , vol.22 , pp. 1355-1363
    • Cook, J.A.1    Burke-Miller, J.K.2    Cohen, M.H.3
  • 26
    • 67650179187 scopus 로고    scopus 로고
    • CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women
    • Feldman DN, Feldman JG, Greenblatt R, et al. CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women. AIDS Educ Prev. 2009;21:81-93.
    • (2009) AIDS Educ Prev. , vol.21 , pp. 81-93
    • Feldman, D.N.1    Feldman, J.G.2    Greenblatt, R.3
  • 27
    • 84255187298 scopus 로고    scopus 로고
    • A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women
    • Crystal HA, Hamon S, Randesi M, et al. A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African American women. Addict Biol. 2012;17:181-191.
    • (2012) Addict Biol. , vol.17 , pp. 181-191
    • Crystal, H.A.1    Hamon, S.2    Randesi, M.3
  • 28
    • 21244497227 scopus 로고    scopus 로고
    • The relationship between non-injection drug use behaviors on progression to AIDS and death in a cohort of HIV seropositive women in the era of highly active antiretroviral therapy use
    • Kapadia F, Cook JA, Cohen MH, et al. The relationship between non-injection drug use behaviors on progression to AIDS and death in a cohort of HIV seropositive women in the era of highly active antiretroviral therapy use. Addiction. 2005;100:990-1002.
    • (2005) Addiction. , vol.100 , pp. 990-1002
    • Kapadia, F.1    Cook, J.A.2    Cohen, M.H.3
  • 29
    • 84861079833 scopus 로고    scopus 로고
    • Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment
    • Proudnikov D, Randesi M, Levran O, et al. Association of polymorphisms of the mu opioid receptor gene with the severity of HIV infection and response to HIV treatment. J Infect Dis. 2012;205:1745-1756.
    • (2012) J Infect Dis. , vol.205 , pp. 1745-1756
    • Proudnikov, D.1    Randesi, M.2    Levran, O.3
  • 30
    • 77952885520 scopus 로고    scopus 로고
    • Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: Impact of long repeats of CNR1
    • Proudnikov D, Kroslak T, Sipe JC, et al. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. Pharmacogenomics J. 2010;10:232-242.
    • (2010) Pharmacogenomics J. , vol.10 , pp. 232-242
    • Proudnikov, D.1    Kroslak, T.2    Sipe, J.C.3
  • 31
    • 34547570844 scopus 로고    scopus 로고
    • Dynorphin gene promoter repeat associated with cocaine/alcohol codependence
    • Williams TJ, LaForge KS, Gordon D, et al. Dynorphin gene promoter repeat associated with cocaine/alcohol codependence. Addict Biol. 2007; 12:496-502.
    • (2007) Addict Biol. , vol.12 , pp. 496-502
    • Williams, T.J.1    Laforge, K.S.2    Gordon, D.3
  • 32
    • 27644433919 scopus 로고    scopus 로고
    • Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    • Dahl JP, Weller AE, Kampman KM, et al. Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. Am J Med Genet B Neuropsychiatr Genet. 2005;139B:106-108.
    • (2005) Am J Med Genet B Neuropsychiatr Genet. , vol.139 B , pp. 106-108
    • Dahl, J.P.1    Weller, A.E.2    Kampman, K.M.3
  • 34
    • 9444290697 scopus 로고    scopus 로고
    • Virologic and immuno-logic benefits of initial combination therapy with zidovudine and zalcita-bine or didanosine compared with zidovudine monotherapy. Wellcome Resistance Study Collaborative Group
    • Schooley RT, Ramirez-Ronda C, Lange JM, et al. Virologic and immuno-logic benefits of initial combination therapy with zidovudine and zalcita-bine or didanosine compared with zidovudine monotherapy. Wellcome Resistance Study Collaborative Group. J Infect Dis. 1996;173:1354-1366.
    • (1996) J Infect Dis. , vol.173 , pp. 1354-1366
    • Schooley, R.T.1    Ramirez-Ronda, C.2    Lange, J.M.3
  • 35
    • 0028003766 scopus 로고
    • Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group
    • Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994;331:1173-1180.
    • (1994) N Engl J Med. , vol.331 , pp. 1173-1180
    • Connor, E.M.1    Sperling, R.S.2    Gelber, R.3
  • 36
    • 33750319817 scopus 로고    scopus 로고
    • Association of the kappa-opioid system with alcohol dependence
    • Xuei X, Dick D, Flury-Wetherill L, et al. Association of the kappa-opioid system with alcohol dependence. Mol Psychiatry. 2006;11:1016-1024.
    • (2006) Mol Psychiatry. , vol.11 , pp. 1016-1024
    • Xuei, X.1    Dick, D.2    Flury-Wetherill, L.3
  • 37
    • 79953173198 scopus 로고    scopus 로고
    • Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain
    • Taqi MM, Bazov I, Watanabe H, et al. Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. Brain Res. 2011; 1385:18-25.
    • (2011) Brain Res. , vol.1385 , pp. 18-25
    • Taqi, M.M.1    Bazov, I.2    Watanabe, H.3
  • 38
    • 67650488993 scopus 로고    scopus 로고
    • An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population
    • Clarke TK, Krause K, Li T, et al. An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population. Addict Biol. 2009;14:366-370.
    • (2009) Addict Biol. , vol.14 , pp. 366-370
    • Clarke, T.K.1    Krause, K.2    Li, T.3
  • 39
    • 67651158814 scopus 로고    scopus 로고
    • Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
    • Kölsch H, Wagner M, Bilkei-Gorzó A, et al. Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. J Neural Transm. 2009;116:897-903.
    • (2009) J Neural Transm. , vol.116 , pp. 897-903
    • Kölsch, H.1    Wagner, M.2    Bilkei-Gorzó, A.3
  • 40
    • 0033954670 scopus 로고    scopus 로고
    • An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression
    • Zimprich A, Kraus J, Wöltje M, et al. An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression. J Neu-rochem. 2000;74:472-477.
    • (2000) J Neu-rochem. , vol.74 , pp. 472-477
    • Zimprich, A.1    Kraus, J.2    Wöltje, M.3
  • 41
    • 79952504209 scopus 로고    scopus 로고
    • Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity
    • Rouault M, Nielsen DA, Ho A, et al. Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addict Biol. 2011;16:334-346.
    • (2011) Addict Biol. , vol.16 , pp. 334-346
    • Rouault, M.1    Nielsen, D.A.2    Ho, A.3
  • 42
    • 74549195536 scopus 로고    scopus 로고
    • Multiple functional variants in cis modulate PDYN expression
    • Babbitt CC, Silverman JS, Haygood R, et al. Multiple functional variants in cis modulate PDYN expression. Mol Biol Evol. 2010;27:465-479.
    • (2010) Mol Biol Evol. , vol.27 , pp. 465-479
    • Babbitt, C.C.1    Silverman, J.S.2    Haygood, R.3
  • 43
    • 79957861034 scopus 로고    scopus 로고
    • Association between heroin dependence and prodynorphin gene polymorphisms
    • Wei SG, Zhu YS, Lai JH, et al. Association between heroin dependence and prodynorphin gene polymorphisms. Brain Res Bull. 2011;85: 238-242.
    • (2011) Brain Res Bull. , vol.85 , pp. 238-242
    • Wei, S.G.1    Zhu, Y.S.2    Lai, J.H.3
  • 44
    • 25444495620 scopus 로고    scopus 로고
    • The role of substance abuse in HIV disease progression: Reconciling differences from laboratory and epidemiologic investigations
    • Kapadia F, Vlahov D, Donahoe RM, et al. The role of substance abuse in HIV disease progression: reconciling differences from laboratory and epidemiologic investigations. Clin Infect Dis. 2005;41:1027-1034.
    • (2005) Clin Infect Dis. , vol.41 , pp. 1027-1034
    • Kapadia, F.1    Vlahov, D.2    Donahoe, R.M.3
  • 45
    • 42349085474 scopus 로고    scopus 로고
    • The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
    • Zhang H, Kranzler HR, Yang BZ, et al. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Mol Psychiatry. 2008;13:531-543.
    • (2008) Mol Psychiatry. , vol.13 , pp. 531-543
    • Zhang, H.1    Kranzler, H.R.2    Yang, B.Z.3
  • 46
    • 80054099649 scopus 로고    scopus 로고
    • Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats
    • Chartoff E, Sawyer A, Rachlin A, et al. Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology. 2012;62:167-176.
    • (2012) Neuropharmacology. , vol.62 , pp. 167-176
    • Chartoff, E.1    Sawyer, A.2    Rachlin, A.3
  • 47
    • 80051472538 scopus 로고    scopus 로고
    • Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats
    • Knoll AT, Muschamp JW, Sillivan SE, et al. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011;70:425-433.
    • (2011) Biol Psychiatry. , vol.70 , pp. 425-433
    • Knoll, A.T.1    Muschamp, J.W.2    Sillivan, S.E.3
  • 48
    • 0042632921 scopus 로고    scopus 로고
    • Depressive disorders and unprotected casual anal sex among Australian homosexually active men in primary care
    • Rogers G, Curry M, Oddy J, et al. Depressive disorders and unprotected casual anal sex among Australian homosexually active men in primary care. HIV Med. 2003;4:271-275.
    • (2003) HIV Med. , vol.4 , pp. 271-275
    • Rogers, G.1    Curry, M.2    Oddy, J.3
  • 49
    • 34548701063 scopus 로고    scopus 로고
    • Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction
    • Gerra G, Leonardi C, Cortese E, et al. Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:771-775.
    • (2007) Am J Med Genet B Neuropsychiatr Genet. , vol.144 B , pp. 771-775
    • Gerra, G.1    Leonardi, C.2    Cortese, E.3
  • 50
    • 11144235902 scopus 로고    scopus 로고
    • Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of hap-lotypes with opiate addiction
    • Yuferov V, Fussell D, LaForge KS, et al. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of hap-lotypes with opiate addiction. Pharmacogenetics. 2004;14:793-804.
    • (2004) Pharmacogenetics. , vol.14 , pp. 793-804
    • Yuferov, V.1    Fussell, D.2    Laforge, K.S.3


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