Computed tomography workup of patients suspected of acute ischemic stroke: Perfusion computed tomography adds value compared with clinical evaluation, noncontrast computed tomography, and computed tomography angiogram in terms of predicting outcome

Stroke

Volumn 44, Issue 4, 2013, Pages 1049-1055

  Zhu, Guangming ^a,c   Michel, Patrik ^b   Aghaebrahim, Amin ^d   Patrie, James T ^a   Xin, Wenjun ^a   Eskandari, Ashraf ^b   Zhang, Weiwei ^c   Wintermark, Max ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Infarct core; Outcome; Penumbra; Perfusion CT; Stroke

Indexed keywords

FIBRINOLYTIC AGENT;

AGED; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CLINICAL EVALUATION; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANKIN SCALE; RETROSPECTIVE STUDY;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANGIOGRAPHY; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; ISCHEMIA; MALE; MIDDLE AGED; PERFUSION; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; STROKE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84876288973     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.674705     Document Type: Article

References (26)

1. González RG. Imaging-guided acute ischemic stroke therapy: from "time is brain" to "physiology is brain". Am J Neuroradiol. 2006;27:728-735.
2. Michel P, Bogousslavsky J. Penumbra is brain: no excuse not to perfuse. Ann Neurol. 2005;58:661-663.
3. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al.; EPITHET investigators. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.
4. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8:141-150.
5. Miteff F, Levi CR, Bateman GA, Spratt N, McElduff P, Parsons MW. The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke. Brain. 2009;132(Pt 8):2231-2238.
6. Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, et al. Collateral vessels on CT angiography predict outcome in acute ischemic stroke. Stroke. 2009;40:3001-3005.
7. González RG, Lev MH, Goldmacher GV, Smith WS, Payabvash S, Harris GJ, et al. Improved outcome prediction using CT angiography in addition to standard ischemic stroke assessment: results from the STOPStroke study. PLoS ONE. 2012;7:e30352.
8. Pulli B, Schaefer PW, Hakimelahi R, Chaudhry ZA, Lev MH, Hirsch JA, et al. Acute ischemic stroke: infarct core estimation on CT angiography source images depends on CT angiography protocol. Radiology. 2012;262:593-604.
9. Souza LC, Yoo AJ, Chaudhry ZA, Payabvash S, Kemmling A, Schaefer PW, et al. Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in acute stroke. Am J Neuroradiol. 2012;33:1331-1336.
10. Tan JC, Dillon WP, Liu S, Adler F, Smith WS, Wintermark M. Systematic comparison of perfusion-CT and CT-Angiography in acute stroke patients. Ann Neurol. 2007;61:533-543.
11. Wintermark M, Thiran JP, Maeder P, Schnyder P, Meuli R. Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study. Am J Neuroradiol. 2001;22: 905-914.
12. Wintermark M, Flanders AE, Velthuis B, Meuli R, van Leeuwen M, Goldsher D, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke. 2006;37:979-985.
13. Kan PT, Snyder KV, Yashar P, Siddiqui AH, Hopkins LN, Levy EI. Utility of CT perfusion scanning in patient selection for acute stroke intervention: experience at University at Buffalo Neurosurgery-Millard Fillmore Gates Circle Hospital. Neurosurg Focus. 2011;30:E4.
14. Hassan AE, Zacharatos H, Rodriguez GJ, Vazquez G, Miley JT, Tummala RP, et al. A comparison of Computed Tomography perfusion-guided and time-guided endovascular treatments for patients with acute ischemic stroke. Stroke. 2010;41:1673-1678.
15. Tong D, Yenari M, Albers G, O'brien M, Marks M, Moseley M. Correlation of perfusion-And diffusion-weighted MRI with NIHSS score in acute (
16. Dzialowski I, Hill MD, Coutts SB, Demchuk AM, Kent DM, Wunderlich O, et al. Extent of early ischemic changes on computed tomography (CT) before thrombolysis. Stroke.2006;37:973-978.
17. Schramm P, Schellinger PD, Fiebach JB, Heiland S, Jansen O, Knauth M, et al. Comparison of CT and CT angiography source images with diffusion-weighted imaging in patients with acute stroke within 6 hours after onset. Stroke. 2002;33:2426-2432.
18. Kent DM, Hill MD, Ruthazer R, Coutts SB, Demchuk AM, Dzialowski I, et al. "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic stroke. Stroke. 2005;36:1695-1699.
19. Lev MH. CT/NIHSS mismatch for detection of salvageable brain in acute stroke triage beyond the 3-hour time window: overrated or undervalued? Stroke. 2007;38:2028-2029.
20. Puetz V, Dzialowski I, Hill MD, Subramaniam S, Sylaja PN, Krol A, et al.; Calgary CTA Study Group. Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score. Int J Stroke. 2008;3:230-236.
21. Tan IY, Demchuk AM, Hopyan J, Zhang L, Gladstone D, Wong K, et al. CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct. Am J Neuroradiol. 2009;30:525-531.
22. Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, et al. Collateral vessels on CT angiography predict outcome in acute ischemic stroke. Stroke. 2009;40:3001-3005.
23. Bang OY, Saver JL, Kim SJ, Kim GM, Chung CS, Ovbiagele B, et al. Collateral flow predicts response to endovascular therapy for acute ischemic stroke. Stroke. 2011;42:693-699.
24. Tan JC, Dillon WP, Liu S, Adler F, Smith WS, Wintermark M. Systematic comparison of perfusion-CT and CT-Angiography in acute stroke patients. Ann Neurol. 2007;61:533-543.
25. Warach S, Al-Rawi Y, Furlan AJ, Fiebach JB, Wintermark M, Lindstén A, et al. Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: insights from the desmoteplase in acute stroke trials. Stroke. 2012;43:2313-2318.
26. Ogata T, Nagakane Y, Christensen S, Ma H, Campbell BC, Churilov L, et al.; EPITHET and DEFUSE Investigators. A topographic study of the evolution of the MR DWI/PWI mismatch pattern and its clinical impact: a study by the EPITHET and DEFUSE Investigators. Stroke. 2011;42:1596-1601.