메뉴 건너뛰기




Volumn 43, Issue 9, 2012, Pages 2313-2318

Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: Insights from the desmoteplase in acute stroke trials

Author keywords

acute cerebral infarction; desmoteplase; diffusion weighted imaging; magnetic resonance imaging; mismatch; perfusion; stroke; thrombolysis

Indexed keywords

DESMOTEPLASE; PLACEBO;

EID: 84865607691     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.642348     Document Type: Article
Times cited : (49)

References (31)
  • 1
    • 0028783948 scopus 로고
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • Tissue plasminogen activator for acute ischemic stroke
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333:1581-1587.
    • (1995) N Engl J Med. , vol.333 , pp. 1581-1587
  • 2
    • 77952112006 scopus 로고    scopus 로고
    • Time to treatment with intravenous alteplase and outcome in stroke: An updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
    • Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet. 2010;375:1695-1703.
    • (2010) Lancet , vol.375 , pp. 1695-1703
    • Lees, K.R.1    Bluhmki, E.2    Von Kummer, R.3    Brott, T.G.4    Toni, D.5    Grotta, J.C.6
  • 3
    • 60049091968 scopus 로고    scopus 로고
    • Penumbral selection of patients for trials of acute stroke therapy
    • Donnan GA, Baron JC, Ma H, Davis SM. Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol. 2009;8:261-269.
    • (2009) Lancet Neurol , vol.8 , pp. 261-269
    • Donnan, G.A.1    Baron, J.C.2    Ma, H.3    Davis, S.M.4
  • 4
    • 0036135970 scopus 로고    scopus 로고
    • Thrombolysis in stroke beyond three hours: Targeting patients with diffusion and perfusion MRI
    • Warach S. Thrombolysis in stroke beyond three hours: Targeting patients with diffusion and perfusion MRI. Ann Neurol. 2002;51:11-13.
    • (2002) Ann Neurol , vol.51 , pp. 11-13
    • Warach, S.1
  • 5
    • 0032822615 scopus 로고    scopus 로고
    • Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection
    • Albers GW. Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection. Stroke. 1999;30:2230-2237.
    • (1999) Stroke , vol.30 , pp. 2230-2237
    • Albers, G.W.1
  • 6
    • 0030958501 scopus 로고    scopus 로고
    • Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging
    • Baird AE, Benfield A, Schlaug G, Siewert B, Lövblad KO, Edelman RR, et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol. 1997; 41:581-589.
    • (1997) Ann Neurol , vol.41 , pp. 581-589
    • Baird, A.E.1    Benfield, A.2    Schlaug, G.3    Siewert, B.4    Lövblad, K.O.5    Edelman, R.R.6
  • 7
    • 0033757829 scopus 로고    scopus 로고
    • Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators
    • Warach S, Pettigrew LC, Dashe JF, Pullicino P, Lefkowitz DM, Sab-ounjian L, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators. Ann Neurol. 2000;48:713-722.
    • (2000) Ann Neurol. , vol.48 , pp. 713-722
    • Warach, S.1    Pettigrew, L.C.2    Dashe, J.F.3    Pullicino, P.4    Lefkowitz, D.M.5    Sab-Ounjian, L.6
  • 8
    • 0032879765 scopus 로고    scopus 로고
    • Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: Evolution of lesion volume and correlation with clinical outcome
    • Beaulieu C, de Crespigny A, Tong DC, Moseley ME, Albers GW, Marks MP. Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome. Ann Neurol. 1999;46:568-578.
    • (1999) Ann Neurol , vol.46 , pp. 568-578
    • Beaulieu, C.1    De Crespigny, A.2    Tong, D.C.3    Moseley, M.E.4    Albers, G.W.5    Marks, M.P.6
  • 9
    • 15144344272 scopus 로고    scopus 로고
    • Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome
    • Lövblad KO, Baird AE, Schlaug G, Benfield A, Siewert B, Voetsch B, et al. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol. 1997;42:164-170.
    • (1997) Ann Neurol , vol.42 , pp. 164-170
    • Lövblad, K.O.1    Baird, A.E.2    Schlaug, G.3    Benfield, A.4    Siewert, B.5    Voetsch, B.6
  • 10
    • 1542349034 scopus 로고    scopus 로고
    • Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: Insights into the pathophysiology of acute stroke in the thrombolysis era
    • Chalela JA, Kang DW, Luby M, Ezzeddine M, Latour LL, Todd JW, et al. Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: Insights into the pathophysiology of acute stroke in the thrombolysis era. Ann Neurol. 2004;55:105-112.
    • (2004) Ann Neurol , vol.55 , pp. 105-112
    • Chalela, J.A.1    Kang, D.W.2    Luby, M.3    Ezzeddine, M.4    Latour, L.L.5    Todd, J.W.6
  • 11
    • 35649009853 scopus 로고    scopus 로고
    • Lesion volume change after treatment with tissue plasminogen activator can discriminate clinical responders from nonresponders
    • Merino JG, Latour LL, Todd JW, Luby M, Schellinger PD, Kang DW, et al. Lesion volume change after treatment with tissue plasminogen activator can discriminate clinical responders from nonresponders. Stroke. 2007;38:2919-2923.
    • (2007) Stroke , vol.38 , pp. 2919-2923
    • Merino, J.G.1    Latour, L.L.2    Todd, J.W.3    Luby, M.4    Schellinger, P.D.5    Kang, D.W.6
  • 12
    • 19944426190 scopus 로고    scopus 로고
    • The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    • Hacke W, Albers G, Al-Rawi Y, Bogousslavsky J, Davalos A, Eliasziw M, et al. The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke. 2005;36:66-73.
    • (2005) Stroke , vol.36 , pp. 66-73
    • Hacke, W.1    Albers, G.2    Al-Rawi, Y.3    Bogousslavsky, J.4    Davalos, A.5    Eliasziw, M.6
  • 13
    • 33646705400 scopus 로고    scopus 로고
    • Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): Evidence of safety and efficacy 3 to 9 hours after stroke onset
    • Furlan AJ, Eyding D, Albers GW, Al-Rawi Y, Lees KR, Rowley HA, et al. Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke. 2006;37:1227-1231.
    • (2006) Stroke , vol.37 , pp. 1227-1231
    • Furlan, A.J.1    Eyding, D.2    Albers, G.W.3    Al-Rawi, Y.4    Lees, K.R.5    Rowley, H.A.6
  • 14
    • 58249134578 scopus 로고    scopus 로고
    • Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): A prospective, randomised, double-blind, placebo-controlled study
    • Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8:141-150.
    • (2009) Lancet Neurol , vol.8 , pp. 141-150
    • Hacke, W.1    Furlan, A.J.2    Al-Rawi, Y.3    Davalos, A.4    Fiebach, J.B.5    Gruber, F.6
  • 15
    • 33845298309 scopus 로고    scopus 로고
    • Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study
    • Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol. 2006;60: 508-517.
    • (2006) Ann Neurol , vol.60 , pp. 508-517
    • Albers, G.W.1    Thijs, V.N.2    Wechsler, L.3    Kemp, S.4    Schlaug, G.5    Skalabrin, E.6
  • 16
    • 40949161352 scopus 로고    scopus 로고
    • Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial
    • Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008;7:299-309.
    • (2008) Lancet Neurol , vol.7 , pp. 299-309
    • Davis, S.M.1    Donnan, G.A.2    Parsons, M.W.3    Levi, C.4    Butcher, K.S.5    Peeters, A.6
  • 18
    • 41249088909 scopus 로고    scopus 로고
    • How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET
    • Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke. 2008;39:870-877.
    • (2008) Stroke , vol.39 , pp. 870-877
    • Takasawa, M.1    Jones, P.S.2    Guadagno, J.V.3    Christensen, S.4    Fryer, T.D.5    Harding, S.6
  • 19
    • 0034839778 scopus 로고    scopus 로고
    • Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient
    • Røhl L, Ostergaard L, Simonsen CZ, Vestergaard-Poulsen P, Andersen G, et al. Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient. Stroke. 2001;32:1140-1146.
    • (2001) Stroke , vol.32 , pp. 1140-1146
    • Røhl, L.1    Ostergaard, L.2    Simonsen, C.Z.3    Vestergaard-Poulsen, P.4    Andersen, G.5
  • 20
    • 36448984002 scopus 로고    scopus 로고
    • Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: Effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes
    • Kane I, Carpenter T, Chappell F, Rivers C, Armitage P, Sandercock P, et al. Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. Stroke. 2007;38:3158-3164.
    • (2007) Stroke , vol.38 , pp. 3158-3164
    • Kane, I.1    Carpenter, T.2    Chappell, F.3    Rivers, C.4    Armitage, P.5    Sandercock, P.6
  • 22
    • 33845415008 scopus 로고    scopus 로고
    • Intra-and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI
    • Luby M, Bykowski JL, Schellinger PD, Merino JG, Warach S. Intra-and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI. Stroke. 2006;37:2951-2956.
    • (2006) Stroke , vol.37 , pp. 2951-2956
    • Luby, M.1    Bykowski, J.L.2    Schellinger, P.D.3    Merino, J.G.4    Warach, S.5
  • 24
    • 66849106746 scopus 로고    scopus 로고
    • Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis
    • Christensen S, Mouridsen K, Wu O, Hjort N, Karstoft H, Thomalla G, et al. Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis. Stroke. 2009;40:2055-2061.
    • (2009) Stroke , vol.40 , pp. 2055-2061
    • Christensen, S.1    Mouridsen, K.2    Wu, O.3    Hjort, N.4    Karstoft, H.5    Thomalla, G.6
  • 25
    • 32344440764 scopus 로고    scopus 로고
    • The association between neurological deficit in acute ischemic stroke and mean transit time: Comparison of four different perfusion MRI algorithms
    • Schellinger PD, Latour LL, Wu CS, Chalela JA, Warach S. The association between neurological deficit in acute ischemic stroke and mean transit time: comparison of four different perfusion MRI algorithms. Neuroradiology. 2006;48:69-77.
    • (2006) Neuroradiology , vol.48 , pp. 69-77
    • Schellinger, P.D.1    Latour, L.L.2    Wu, C.S.3    Chalela, J.A.4    Warach, S.5
  • 26
    • 0036235007 scopus 로고    scopus 로고
    • Which MR-derived perfusion parameters are the best predictors of infarct growth in hyperacute stroke? Comparative study between relative and quantitative measurements
    • Grandin CB, Duprez TP, Smith AM, Oppenheim C, Peeters A, Robert AR, et al. Which MR-derived perfusion parameters are the best predictors of infarct growth in hyperacute stroke? Comparative study between relative and quantitative measurements. Radiology. 2002;223:361-370.
    • (2002) Radiology , vol.223 , pp. 361-370
    • Grandin, C.B.1    Duprez, T.P.2    Smith, A.M.3    Oppenheim, C.4    Peeters, A.5    Robert, A.R.6
  • 27
    • 79952186957 scopus 로고    scopus 로고
    • Susceptibility of Tmax to tracer delay on perfusion analysis: Quantitative evaluation of various deconvolution algorithms using digital phantoms
    • Kudo K, Sasaki M, Østergaard L, Christensen S, Uwano I, Suzuki M, et al. Susceptibility of Tmax to tracer delay on perfusion analysis: quantitative evaluation of various deconvolution algorithms using digital phantoms. J Cereb Blood Flow Metab. 2011;31:908-912.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 908-912
    • Kudo, K.1    Sasaki, M.2    Østergaard, L.3    Christensen, S.4    Uwano, I.5    Suzuki, M.6
  • 28
    • 79958253393 scopus 로고    scopus 로고
    • RAPID automated patient selection for reperfusion therapy: A pooled analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study
    • Lansberg MG, Lee J, Christensen S, Straka M, De Silva DA, Mlynash M, et al. RAPID automated patient selection for reperfusion therapy: a pooled analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study. Stroke. 2011;42: 1608-1614.
    • (2011) Stroke , vol.42 , pp. 1608-1614
    • Lansberg, M.G.1    Lee, J.2    Christensen, S.3    Straka, M.4    De Silva, D.A.5    Mlynash, M.6
  • 30
    • 84861580849 scopus 로고    scopus 로고
    • Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase
    • Fiebach JB, Al-Rawi Y, Wintermark M, Furlan AJ, Rowley HA, Lindsten A, et al. Vascular occlusion enables selecting acute ischemic stroke patients for treatment with desmoteplase. Stroke. 2012;43:1561-1566.
    • (2012) Stroke , vol.43 , pp. 1561-1566
    • Fiebach, J.B.1    Al-Rawi, Y.2    Wintermark, M.3    Furlan, A.J.4    Rowley, H.A.5    Lindsten, A.6
  • 31
    • 77953128781 scopus 로고    scopus 로고
    • Pretreatment diffusion-and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis
    • Parsons MW, Christensen S, McElduff P, Levi CR, Butcher KS, De Silva DA, et al. Pretreatment diffusion-and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab. 2010;30:1214-1225.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1214-1225
    • Parsons, M.W.1    Christensen, S.2    McElduff, P.3    Levi, C.R.4    Butcher, K.S.5    De Silva, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.