Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: The clot burden score

International Journal of Stroke

Volumn 3, Issue 4, 2008, Pages 230-236

  Puetz, Volker ^a,b   Dzialowski, Imanuel ^a,b   Hill, Michael D ^a   Subramaniam, Suresh ^a   Sylaja, P N ^a,c   Krol, Andrea ^d   O'Reilly, Christine ^d   Hudon, Mark E ^a   Hu, William Y ^a   Coutts, Shelagh B ^a   Barber, Philip A ^a   Watson, Timothy ^a   Roy, Jayanta ^a,e   Demchuk, Andrew M ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c Ananthapuri Hospitals and Research Institute   (India)

^d FOOTHILLS HOSPITAL   (Canada)

^e National Neurosciences Centre   (India)

Author keywords

Acute ischemic stroke; Computed tomography; CT angiography; Outcome; Thrombus

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BRAIN HEMATOMA; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; CEREBROVASCULAR ACCIDENT; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; FEMALE; HUMAN; IMAGE ANALYSIS; INTERNAL CAROTID ARTERY; INTERRATER RELIABILITY; INTRACRANIAL THROMBUS; INTRARATER RELIABILITY; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SCORING SYSTEM; SYMPTOM; THROMBUS;

AGED; BRAIN INFARCTION; CEREBRAL ANGIOGRAPHY; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INTRACRANIAL THROMBOSIS; MALE; RECOVERY OF FUNCTION; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, X-RAY COMPUTED;

EID: 52249123068     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2008.00221.x     Document Type: Article

References (32)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581-7.
2. Rha JH, Saver JL: The impact of recanalization on ischemic stroke outcome: A meta-analysis. Stroke 2007; 38:967-73.
3. Molina CA, Alexandrov AV, Demchuk AM, Saqqur M, Uchino K, Alvarez-Sabin J: Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 2004; 35:151-6.
4. Wunderlich MT, Goertler M, Postert T et al. Recanalization after intravenous thrombolysis: Does a recanalization time window exist? Neurology 2007; 68:1364-8.
5. Mattle HP: Intravenous or intra-arterial thrombolysis? It's time to find the right approach for the right patient. Stroke 2007; 38:2038-40.
6. von Kummer R, Holle R, Rosin L, Forsting M, Hacke W: Does arterial recanalization improve outcome in carotid territory stroke? Stroke 1995; 26:581-7.
7. del Zoppo GJ, Poeck K, Pessin MS et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 1992; 32:78-86.
8. Saqqur M, Uchino K, Demchuk AM et al. Site of arterial occlusion identified by transcranial doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007; 38:948-54.
9. Lee KY, Han SW, Kim SH et al. Early recanalization after intravenous administration of recombinant tissue plasminogen activator as assessed by pre- and post-thrombolytic angiography in acute ischemic stroke patients. Stroke 2007; 38:192-3.
10. Linfante I, Llinas RH, Selim M et al. Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator. Stroke 2002; 33:2066-71.
11. Jansen O, von Kummer R, Forsting M, Hacke W, Sartor K: Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation. AJNR Am J Neuroradiol 1995; 16:1977-86.
12. Sims JR, Rordorf G, Smith EE, Koroshetz WJ, Lev MH, Buonanno F, Schwamm LH: Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment. AJNR Am J Neuroradiol 2005; 26:246-51.
13. Krol AL, Dzialowski I, Roy J, Puetz V, Subramaniam S, Coutts SB, Demchuk AM: Incidence of radiocontrast nephropathy in patients undergoing acute stroke computed tomography angiography. Stroke 2007; 38:2364-6.
14. Lev MH, Farkas J, Rodriguez VR et al. CT angiography in the rapid triage of patients with hyperacute stroke to intraarterial thrombolysis: accuracy in the detection of large vessel thrombus. J Comput Assist Tomogr 2001; 25:520-8.
15. Ritter MA, Poeplau T, Schaefer A et al. CT angiography in acute stroke: does it provide additional information on occurrence of infarction and functional outcome after 3 months? Cerebrovasc Dis 2006; 22:362-7.
16. Goldstein LB, Chilukuri V: Retrospective assessment of initial stroke severity with the Canadian Neurological Scale. Stroke 1997; 28:1181-4.
17. Adams HP, Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE III: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of org 10172 in acute stroke treatment. Stroke 1993; 24:35-41.
18. Barber PA, Demchuk AM, Zhang J, Buchan AM: Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS study group. Alberta Stroke Programme Early CT Score. Lancet 2000; 355:1670-4.
19. Barber PA, Hill MD, Eliasziw M et al. Imaging of the brain in acute ischaemic stroke: Comparison of computed tomography and magnetic resonance diffusion-weighted imaging. J Neurol Neurosurg Psychiatry 2005; 76:1528-33.
20. Hacke W, Kaste M, Fieschi C et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study investigators. Lancet 1998; 352:1245-51.
21. Brotman DJ, Walker E, Lauer MS, O'Brien RG: In search of fewer independent risk factors. Arch Intern Med 2005; 165:138-45.
22. Kraemer HC, Stice E, Kazdin A, Offord D, Kupfer D: How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. Am J Psychiatry 2001; 158:848-56.
23. Eliasziw M, Young SL, Woodbury MG, Fryday-Field K: Statistical methodology for the concurrent assessment of interrater and intrarater reliability: Using goniometric measurements as an example. Phys Ther 1994; 74:777-88.
24. Mohammad Y, Xavier AR, Christoforidis G, Bourekas E, Slivka A: Qureshi grading scheme for angiographic occlusions strongly correlates with the initial severity and in-hospital outcome of acute ischemic stroke. J Neuroimaging 2004; 14:235-41.
25. Qureshi AI: New grading system for angiographic evaluation of arterial occlusions and recanalization response to intra-arterial thrombolysis in acute ischemic stroke. Neurosurgery 2002; 50:1405-14; discussion 1414-1405.
26. Khatri P, Hill MD, Palesch YY et al. Methodology of the Interventional Management of Stroke III trial. Int J Stroke 2008; 3:130-7.
27. http://www.combatstroke.org/. Accessed on September 21, 2007.
28. Barak ER, Nogueira RG, Lev M et al. Assessing the effect of clot location and burden on outcome in patients with anterior circulation infarction treated with intraarterial therapy. ASNR Proceedings 2007; 145 (abstract 271).
29. Alexandrov AV, Black SE, Ehrlich LE, Caldwell CB, Norris JW: Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke. Stroke 1997; 28:1198-202.
30. Dzialowski I, Hill MD, Coutts SB, Demchuk AM, Kent DM, Wunderlich O, von Kummer R: Extent of early ischemic changes on computed tomography (CT) before thrombolysis, prognostic value of the Alberta Stroke Program Early CT Score in ECASS II. Stroke 2006; 37:973-8.
31. Kucinski T, Koch C, Eckert B et al. Collateral circulation is an independent radiological predictor of outcome after thrombolysis in acute ischaemic stroke. Neuroradiology 2003; 45:11-8.
32. Christoforidis GA, Mohammad Y, Kehagias D, Avutu B, Slivka AP: Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 2005; 26:1789-97.