메뉴 건너뛰기




Volumn 43, Issue 4, 2012, Pages 562-569

A phase II study of capecitabine, oxaliplatin, and cetuximab with or without bevacizumab as frontline therapy for metastatic colorectal cancer. A fox chase extramural research study

Author keywords

Epidermal growth factor receptor (EGFR); Metastatic colon cancer; Vascular endothelial growth factor (VEGF)

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; OXALIPLATIN;

EID: 84876288831     PISSN: 19416628     EISSN: 19416636     Source Type: Journal    
DOI: 10.1007/s12029-012-9368-3     Document Type: Article
Times cited : (25)

References (27)
  • 1
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • 14665611 10.1200/JCO.2004.09.046 1:CAS:528:DC%2BD2cXpsVKitbY%3D
    • Goldberg RM, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004;22(1):23-30.
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 23-30
    • Goldberg, R.M.1
  • 2
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
    • 15169795 10.1200/JCO.2004.11.069 1:CAS:528:DC%2BD2cXpsVWlsL8%3D
    • Cassidy J, et al. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol. 2004;22(11):2084-91.
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2084-2091
    • Cassidy, J.1
  • 3
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
    • 11689577
    • Van Cutsem E, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol. 2001;19(21):4097-106.
    • (2001) J Clin Oncol , vol.19 , Issue.21 , pp. 4097-4106
    • Van Cutsem, E.1
  • 4
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • 11304782 1:CAS:528:DC%2BD3MXjsFeqsrw%3D
    • Hoff PM, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol. 2001;19(8):2282-92.
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2282-2292
    • Hoff, P.M.1
  • 5
    • 42949150908 scopus 로고    scopus 로고
    • Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer
    • 18421053 10.1200/JCO.2007.14.9898 1:CAS:528:DC%2BD1cXlvFaqs7s%3D
    • Cassidy J, et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol. 2008;26(12):2006-12.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2006-2012
    • Cassidy, J.1
  • 6
    • 33750344252 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of metastatic colorectal cancer: Safety profile and management of adverse events
    • 17145522 10.1053/j.seminoncol.2006.08.001 1:CAS:528:DC%2BD28Xhtlajt7vM
    • Hurwitz H, Saini S. Bevacizumab in the treatment of metastatic colorectal cancer: safety profile and management of adverse events. Semin Oncol. 2006;33(5 Suppl 10):S26-34.
    • (2006) Semin Oncol , vol.33 , Issue.5 SUPPL. 10 , pp. 26-34
    • Hurwitz, H.1    Saini, S.2
  • 7
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • 17442997 10.1200/JCO.2006.09.6305 1:CAS:528:DC%2BD2sXlsVyntbc%3D
    • Giantonio BJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25(12):1539-44.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1
  • 8
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • 18421054 10.1200/JCO.2007.14.9930 1:CAS:528:DC%2BD1cXlvFaqs7g%3D
    • Saltz LB, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26(12):2013-9.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1
  • 9
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • 14993230 10.1200/JCO.2004.10.182 1:CAS:528:DC%2BD2cXpsVGktLw%3D
    • Saltz LB, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol. 2004;22(7):1201-8.
    • (2004) J Clin Oncol , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1
  • 10
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • 15269313 10.1056/NEJMoa033025 1:CAS:528:DC%2BD2cXlvFGitbk%3D
    • Cunningham D, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med. 2004;351(4):337-45.
    • (2004) N Engl J Med , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1
  • 11
    • 36749067866 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
    • 18024868 10.1200/JCO.2007.13.2183 1:CAS:528:DC%2BD2sXhsVKnsbzI
    • Tabernero J, et al. Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2007;25(33):5225-32.
    • (2007) J Clin Oncol , vol.25 , Issue.33 , pp. 5225-5232
    • Tabernero, J.1
  • 12
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
    • Bokemeyer C et al. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol. 2011;22(7):1535-46.
    • (2011) Ann Oncol , vol.22 , Issue.7 , pp. 1535-1546
    • Bokemeyer, C.1
  • 13
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • 20921465 10.1200/JCO.2009.27.4860 1:CAS:528:DC%2BC3cXhsF2rtLzI
    • Douillard JY, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010;28(31):4697-705.
    • (2010) J Clin Oncol , vol.28 , Issue.31 , pp. 4697-4705
    • Douillard, J.Y.1
  • 14
    • 71449100773 scopus 로고    scopus 로고
    • A meta-analysis of the CRYSTAL and OPUS studies combining cetuximab with chemotherapy (CT) as 1st-line treatment for patients (pts) with metastatic colorectal cancer (mCRC): Results according to KRAS and BRAF mutation status
    • 10.1016/S1359-6349(09)71172-3 Abstract # P-6077
    • Van Cutsem E, et al. A meta-analysis of the CRYSTAL and OPUS studies combining cetuximab with chemotherapy (CT) as 1st-line treatment for patients (pts) with metastatic colorectal cancer (mCRC): results according to KRAS and BRAF mutation status. Eur J Cancer Suppl. 2009;7(2):345. Abstract # P-6077.
    • (2009) Eur J Cancer Suppl , vol.7 , Issue.2 , pp. 345
    • Van Cutsem, E.1
  • 15
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • 18946061 10.1056/NEJMoa0804385 1:CAS:528:DC%2BD1cXht12nu77J
    • Karapetis CS, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008;359(17):1757-65.
    • (2008) N Engl J Med , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1
  • 16
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • 10999768 1:CAS:528:DC%2BD3cXntFCitrk%3D
    • Ciardiello F, et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res. 2000;6(9):3739-47.
    • (2000) Clin Cancer Res , vol.6 , Issue.9 , pp. 3739-3747
    • Ciardiello, F.1
  • 17
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • 17876013 10.1200/JCO.2007.12.0949 1:CAS:528:DC%2BD2sXht1yhsr%2FM
    • Saltz LB, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol. 2007;25(29):4557-61.
    • (2007) J Clin Oncol , vol.25 , Issue.29 , pp. 4557-4561
    • Saltz, L.B.1
  • 18
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • 10655437 10.1093/jnci/92.3.205 1:STN:280:DC%2BD3c7it1Gitg%3D%3D
    • Therasse P. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92(3):205-16.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.3 , pp. 205-216
    • Therasse, P.1
  • 19
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • 19196673 10.1056/NEJMoa0808268 1:CAS:528:DC%2BD1MXhsFyitrw%3D
    • Tol J, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360(6):563-72.
    • (2009) N Engl J Med , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1
  • 20
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • 19114685 10.1200/JCO.2008.19.8135 1:CAS:528:DC%2BD1MXjsVCjs74%3D
    • Hecht JR, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27(5):672-80.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1
  • 21
    • 79851496674 scopus 로고    scopus 로고
    • A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer
    • 21273607 1:CAS:528:DC%2BC3MXisVams78%3D
    • Wong NS, et al. A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer. Anticancer Res. 2011;31(1):255-61.
    • (2011) Anticancer Res , vol.31 , Issue.1 , pp. 255-261
    • Wong, N.S.1
  • 22
    • 57449096129 scopus 로고    scopus 로고
    • Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741
    • 19001325 10.1200/JCO.2008.17.7147 1:CAS:528:DC%2BD1MXotFemtg%3D%3D
    • Sanoff HK, et al. Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741. J Clin Oncol. 2008;26(35):5721-7.
    • (2008) J Clin Oncol , vol.26 , Issue.35 , pp. 5721-5727
    • Sanoff, H.K.1
  • 23
    • 75649085336 scopus 로고    scopus 로고
    • More is less - Combining targeted therapies in metastatic colorectal cancer
    • 19942926 10.1038/nrclinonc.2009.168 1:CAS:528:DC%2BD1MXhsVynur3P
    • Punt CJ, Tol J. More is less - combining targeted therapies in metastatic colorectal cancer. Nat Rev Clin Oncol. 2009;6(12):731-3.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.12 , pp. 731-733
    • Punt, C.J.1    Tol, J.2
  • 24
    • 73449100517 scopus 로고    scopus 로고
    • Vascular endothelial growth factor plus epidermal growth factor receptor dual targeted therapy in metastatic colorectal cancer: Synergy or antagonism?
    • 20016807 10.1155/2009/937305
    • Marshall JL. Vascular endothelial growth factor plus epidermal growth factor receptor dual targeted therapy in metastatic colorectal cancer: synergy or antagonism? J Oncol. 2009;2009:937305.
    • (2009) J Oncol , vol.2009 , pp. 937305
    • Marshall, J.L.1
  • 25
    • 37849049198 scopus 로고    scopus 로고
    • Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis
    • 18178171 10.1016/j.bcp.2007.09.029 1:CAS:528:DC%2BD1cXlvVOhtw%3D%3D
    • Selvakumaran M, et al. Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis. Biochem Pharmacol. 2008;75(3):627-38.
    • (2008) Biochem Pharmacol , vol.75 , Issue.3 , pp. 627-638
    • Selvakumaran, M.1
  • 26
    • 49849084552 scopus 로고    scopus 로고
    • Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab
    • 18483308 10.1158/1535-7163.MCT-07-2187 1:CAS:528:DC%2BD1cXlvFamsro%3D
    • Li X, et al. Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab. Mol Cancer Ther. 2008;7(5):1207-17.
    • (2008) Mol Cancer Ther , vol.7 , Issue.5 , pp. 1207-1217
    • Li, X.1
  • 27
    • 77955179588 scopus 로고    scopus 로고
    • Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells
    • 20532039 10.1371/journal.pone.0010966
    • Zeng M, et al. Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells. PLoS One. 2010;5(6):e10966.
    • (2010) PLoS One , vol.5 , Issue.6 , pp. 10966
    • Zeng, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.