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Volumn 97, Issue 2, 2013, Pages 115-131

Identification and analysis of two novel sites of rat GnRH receptor gene promoter activity: The pineal gland and retina

Author keywords

GnRH receptor; Gonadotrope; hPLAP; OTX2; Pineal gland; Pituitary; Retina; Transcription factors; Transgenesis

Indexed keywords

ALKALINE PHOSPHATASE PLACENTA ISOENZYME; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GONADORELIN RECEPTOR; PROP1 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ISL1; TRANSCRIPTION FACTOR LHX3; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG;

EID: 84876284236     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000337661     Document Type: Article
Times cited : (8)

References (58)
  • 2
    • 0025241805 scopus 로고
    • GnRH receptors in rat brain, pituitary and testis; Modulation following surgical and gonadotropin-releasing hormone agonist-induced castration
    • Ban E, Crumeyrolle-Arias M, Latouche J, Leblanc P, Heurtier JF, Drieu K, Fillion G, Haour F: GnRH receptors in rat brain, pituitary and testis; modulation following surgical and gonadotropin-releasing hormone agonist-induced castration. Mol Cell Endocrinol 1990; 26: 99-107.
    • (1990) Mol Cell Endocrinol , vol.26 , pp. 99-107
    • Ban, E.1    Crumeyrolle-Arias, M.2    Latouche, J.3    Leblanc, P.4    Heurtier, J.F.5    Drieu, K.6    Fillion, G.7    Haour, F.8
  • 3
    • 0030630196 scopus 로고    scopus 로고
    • Brain gonadotropin releasing hormone receptors: Localization and regulation
    • Jennes L, Eyigor O, Janovick JA, Conn PM: Brain gonadotropin releasing hormone receptors: localization and regulation. Recent Prog Horm Res 1997; 52: 475-490.
    • (1997) Recent Prog Horm Res , vol.52 , pp. 475-490
    • Jennes, L.1    Eyigor, O.2    Janovick, J.A.3    Conn, P.M.4
  • 5
    • 0028300686 scopus 로고
    • Nucleotide sequence analysis of mRNAs predicts that rat pituitary and gonadal gonadotropinreleasing hormone receptor proteins have identical primary structure
    • Moumni M, Kottler ML, Counis R: Nucleotide sequence analysis of mRNAs predicts that rat pituitary and gonadal gonadotropinreleasing hormone receptor proteins have identical primary structure. Biochem Biophys Res Commun 1994; 200: 1359-1366.
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 1359-1366
    • Moumni, M.1    Kottler, M.L.2    Counis, R.3
  • 7
    • 11244260381 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone and its receptor in normal and malignant cells
    • Harrison GS, Wierman ME, Nett TM, Glode LM: Gonadotropin-releasing hormone and its receptor in normal and malignant cells. Endocr Relat Cancer 2004; 11: 725-748.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 725-748
    • Harrison, G.S.1    Wierman, M.E.2    Nett, T.M.3    Glode, L.M.4
  • 8
    • 0033015566 scopus 로고    scopus 로고
    • Human peripheral blood mononuclear cells express gonadotropin-releasing hormone (GnRH), GnRH receptor, and interleukin-2 receptor alpha; -chain messenger ribonucleic acids that are regulated by GnRH in vitro
    • Chen HF, Jeung EB, Stephenson M, Leung PC: Human peripheral blood mononuclear cells express gonadotropin-releasing hormone (GnRH), GnRH receptor, and interleukin-2 receptor alpha; -chain messenger ribonucleic acids that are regulated by GnRH in vitro. J Clin Endocrinol Metab 1999; 84: 743-750.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 743-750
    • Chen, H.F.1    Jeung, E.B.2    Stephenson, M.3    Leung, P.C.4
  • 9
    • 0030923675 scopus 로고    scopus 로고
    • The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer
    • Kottler ML, Starzec A, Carre MC, Lagarde JP, Martin A, Counis R: The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer. Int J Cancer 1997; 71: 595-599.
    • (1997) Int J Cancer , vol.71 , pp. 595-599
    • Kottler, M.L.1    Starzec, A.2    Carre, M.C.3    Lagarde, J.P.4    Martin, A.5    Counis, R.6
  • 10
    • 10744233163 scopus 로고    scopus 로고
    • The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues
    • Granger A, Ngô-Muller V, Bleux C, Guigon C, Pincas H, Magre S, Daegelen D, Tixier-Vidal A, Counis R, Laverrière JN: The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues. Endocrinology 2004; 145: 983-993.
    • (2004) Endocrinology , vol.145 , pp. 983-993
    • Granger, A.1    Ngô-Muller, V.2    Bleux, C.3    Guigon, C.4    Pincas, H.5    Magre, S.6    Daegelen, D.7    Tixier-Vidal, A.8    Counis, R.9    Laverrière, J.N.10
  • 14
    • 33747824859 scopus 로고    scopus 로고
    • The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropinreleasing hormone receptor gene promoter
    • Granger A, Bleux C, Kottler ML, Rhodes SJ, Counis R, Laverrière JN: The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropinreleasing hormone receptor gene promoter. Mol Endocrinol 2006; 20: 2093-2108.
    • (2006) Mol Endocrinol , vol.20 , pp. 2093-2108
    • Granger, A.1    Bleux, C.2    Kottler, M.L.3    Rhodes, S.J.4    Counis, R.5    Laverrière, J.N.6
  • 16
    • 0038386025 scopus 로고    scopus 로고
    • Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors
    • Lee SK, Pfaff SL: Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 2003; 38: 731-745.
    • (2003) Neuron , vol.38 , pp. 731-745
    • Lee, S.K.1    Pfaff, S.L.2
  • 17
    • 38149033662 scopus 로고    scopus 로고
    • Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina
    • Fischer AJ, Foster S, Scott MA, Sherwood P: Transient expression of LIM-domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina. J Comp Neurol 2008; 506: 584-603.
    • (2008) J Comp Neurol , vol.506 , pp. 584-603
    • Fischer, A.J.1    Foster, S.2    Scott, M.A.3    Sherwood, P.4
  • 18
    • 36248950219 scopus 로고    scopus 로고
    • Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells
    • Elshatory Y, Everhart D, Deng M, Xie X, Barlow RB, Gan L: Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci 2007; 27: 12707-12720.
    • (2007) J Neurosci , vol.27 , pp. 12707-12720
    • Elshatory, Y.1    Everhart, D.2    Deng, M.3    Xie, X.4    Barlow, R.B.5    Gan, L.6
  • 20
    • 57349103617 scopus 로고    scopus 로고
    • A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency
    • Diaczok D, Romero C, Zunich J, Marshall I, Radovick S: A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. J Clin Endocrinol Metab 2008; 93: 4351-4359.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4351-4359
    • Diaczok, D.1    Romero, C.2    Zunich, J.3    Marshall, I.4    Radovick, S.5
  • 21
    • 58149383817 scopus 로고    scopus 로고
    • OTX2 loss of function mutation causes anophthalmia and combined pituitary hormone deficiency with a small anterior and ectopic posterior pituitary
    • Tajima T, Ohtake A, Hoshino M, Amemiya S, Sasaki N, Ishizu K, Fujieda K: OTX2 loss of function mutation causes anophthalmia and combined pituitary hormone deficiency with a small anterior and ectopic posterior pituitary. J Clin Endocrinol Metab 2009; 94: 314-319.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 314-319
    • Tajima, T.1    Ohtake, A.2    Hoshino, M.3    Amemiya, S.4    Sasaki, N.5    Ishizu, K.6    Fujieda, K.7
  • 24
    • 3242713077 scopus 로고    scopus 로고
    • The 2004 Aschoff/Pittendrigh lecture: Theory of the origin of the pineal gland - A tale of conflict and resolution
    • Klein DC: The 2004 Aschoff/Pittendrigh lecture: theory of the origin of the pineal gland -a tale of conflict and resolution. J Biol Rhythms 2004; 19: 264-279.
    • J Biol Rhythms , vol.2004 , Issue.19 , pp. 264-279
    • Klein, D.C.1
  • 25
    • 33645307718 scopus 로고    scopus 로고
    • Expression of the Otx2 homeobox gene in the developing mammalian brain: Embryonic and adult expression in the pineal gland
    • Rath MF, Muñoz E, Ganguly S, Morin F, Shi Q, Klein DC, Møller M: Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J Neurochem 2006; 97: 556-566.
    • (2006) J Neurochem , vol.97 , pp. 556-566
    • Rath, M.F.1    Muñoz, E.2    Ganguly, S.3    Morin, F.4    Shi, Q.5    Klein, D.C.6    Møller, M.7
  • 27
  • 28
    • 0032749223 scopus 로고    scopus 로고
    • Retinopathy and attenuated circadian entrainment in Crx-deficient mice
    • Furukawa T, Morrow EM, Li T, Davis FC, Cepko CL: Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet 1999; 23: 466-470.
    • (1999) Nat Genet , vol.23 , pp. 466-470
    • Furukawa, T.1    Morrow, E.M.2    Li, T.3    Davis, F.C.4    Cepko, C.L.5
  • 29
    • 0035193550 scopus 로고    scopus 로고
    • The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ
    • Estivill-Torrús G, Vitalis T, Fernández-Llebrez P, Price DJ: The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ. Mech Dev 2001; 109: 215-224.
    • (2001) Mech Dev , vol.109 , pp. 215-224
    • Estivill-Torrús, G.1    Vitalis, T.2    Fernández-Llebrez, P.3    Price, D.J.4
  • 32
    • 67649660558 scopus 로고    scopus 로고
    • Development of gonadotropin-releasing hormone-1 secretion in mouse nasal explants
    • Constantin S, Caraty A, Wray S, Duittoz AH: Development of gonadotropin-releasing hormone-1 secretion in mouse nasal explants. Endocrinology 2009; 150: 3221-3227.
    • (2009) Endocrinology , vol.150 , pp. 3221-3227
    • Constantin, S.1    Caraty, A.2    Wray, S.3    Duittoz, A.H.4
  • 33
    • 58649119076 scopus 로고    scopus 로고
    • The influence of catecholamine on the migration of gonadotropin-releasing hormone-producing neurons in the rat foetuses
    • Izvolskaia M, Duittoz AH, Tillet Y, Ugrumov MV: The influence of catecholamine on the migration of gonadotropin-releasing hormone-producing neurons in the rat foetuses. Brain Struct Funct 2009; 213: 289-300.
    • (2009) Brain Struct Funct , vol.213 , pp. 289-300
    • Izvolskaia, M.1    Duittoz, A.H.2    Tillet, Y.3    Ugrumov, M.V.4
  • 34
    • 0035968180 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide and cyclic adenosine 3′ ,5′ -monophosphate stimulate the promoter activity of the rat gonadotropin-releasing hormone receptor gene via a bipartite response element in gonadotrope-derived cells
    • Pincas H, Laverrière JN, Counis R: Pituitary adenylate cyclase-activating polypeptide and cyclic adenosine 3′ ,5′ -monophosphate stimulate the promoter activity of the rat gonadotropin-releasing hormone receptor gene via a bipartite response element in gonadotrope-derived cells. J Biol Chem 2001; 276: 23562-23571.
    • (2001) J Biol Chem , vol.276 , pp. 23562-23571
    • Pincas, H.1    Laverrière, J.N.2    Counis, R.3
  • 35
    • 0035147034 scopus 로고    scopus 로고
    • Proximal cis -acting elements, including steroidogenic factor 1, mediate the efficiency of a distal enhancer in the promoter of the rat gonadotropin-releasing hormone receptor gene
    • Pincas H, Amoyel K, Counis R, Laverrière JN: Proximal cis -acting elements, including steroidogenic factor 1, mediate the efficiency of a distal enhancer in the promoter of the rat gonadotropin-releasing hormone receptor gene. Mol Endocrinol 2001; 15: 319-337.
    • (2001) Mol Endocrinol , vol.15 , pp. 319-337
    • Pincas, H.1    Amoyel, K.2    Counis, R.3    Laverrière, J.N.4
  • 38
    • 33645510778 scopus 로고    scopus 로고
    • Role of Prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty
    • Vesper AH, Raetzman LT, Camper SA: Role of Prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology 2006; 147: 1654-1663.
    • (2006) Endocrinology , vol.147 , pp. 1654-1663
    • Vesper, A.H.1    Raetzman, L.T.2    Camper, S.A.3
  • 40
    • 0038070656 scopus 로고    scopus 로고
    • Expression of the mouse gonadotropin-releasing hormone receptor gene inα T3-1 gonadotrope cells is stimulated by cyclic 3′ ,5′ -adenosine monophosphate and protein kinase A, and is modulated by steroidogenic factor-1 and Nur77
    • Sadie H, Styger G, Hapgood J: Expression of the mouse gonadotropin-releasing hormone receptor gene inα T3-1 gonadotrope cells is stimulated by cyclic 3′ ,5′ -adenosine monophosphate and protein kinase A, and is modulated by steroidogenic factor-1 and Nur77. Endocrinology 2003; 144: 1958-1971.
    • (2003) Endocrinology , vol.144 , pp. 1958-1971
    • Sadie, H.1    Styger, G.2    Hapgood, J.3
  • 41
    • 80053914021 scopus 로고    scopus 로고
    • Candidate genes for panhypopituitarism identified by gene expression profiling
    • Mortensen AH, Macdonald JW, Ghosh D, Camper SA: Candidate genes for panhypopituitarism identified by gene expression profiling. Physiol Genomics 2011; 43: 1105-1116.
    • (2011) Physiol Genomics , vol.43 , pp. 1105-1116
    • Mortensen, A.H.1    Macdonald, J.W.2    Ghosh, D.3    Camper, S.A.4
  • 42
    • 0033866686 scopus 로고    scopus 로고
    • Expression of synaptic vesicle trafficking proteins in the developing rat pineal gland
    • Redecker P: Expression of synaptic vesicle trafficking proteins in the developing rat pineal gland. Cell Tissue Res 2000;301: 255-265.
    • (2000) Cell Tissue Res , vol.301 , pp. 255-265
    • Redecker, P.1
  • 43
    • 79955734857 scopus 로고    scopus 로고
    • Circadian melatonin production develops faster in birds than in mammals
    • Zeman M, Herichová I: Circadian melatonin production develops faster in birds than in mammals. Gen Comp Endocrinol 2011; 172: 23-30.
    • (2011) Gen Comp Endocrinol , vol.172 , pp. 23-30
    • Zeman, M.1    Herichová, I.2
  • 45
    • 20544477472 scopus 로고    scopus 로고
    • Two visual processing pathways are targeted by gonadotropin-releasing hormone in the retina
    • Grens KE, Greenwood AK, Fernaldab RD: Two visual processing pathways are targeted by gonadotropin-releasing hormone in the retina. Brain Behav Evol 2005; 66: 1-9.
    • (2005) Brain Behav Evol , vol.66 , pp. 1-9
    • Grens, K.E.1    Greenwood, A.K.2    Fernaldab, R.D.3
  • 46
    • 33947520455 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone and receptor distributions in the visual processing regions of four coral reef fishes
    • Maruska KP, Tricas TC: Gonadotropin-releasing hormone and receptor distributions in the visual processing regions of four coral reef fishes. Brain Behav Evol 2007; 70: 40-56.
    • (2007) Brain Behav Evol , vol.70 , pp. 40-56
    • Maruska, K.P.1    Tricas, T.C.2
  • 48
    • 0037144138 scopus 로고    scopus 로고
    • Vole retina is a target for gonadotropin-releasing hormone
    • Wirsig-Wiechmann CR, Wiechmann AF: Vole retina is a target for gonadotropin-releasing hormone. Brain Res 2002; 950: 210-217.
    • (2002) Brain Res , vol.950 , pp. 210-217
    • Wirsig-Wiechmann, C.R.1    Wiechmann, A.F.2
  • 49
    • 1942444510 scopus 로고    scopus 로고
    • Cloning and expression of gonadotropin-releasing hormone receptor in the brain and pituitary of the European sea bass: An in situ hybridization study
    • González-Martínez D, Madigou T, Mañanos E, Cerdá-Reverter JM, Zanuy S, Kah O, Muñoz-Cueto JA: Cloning and expression of gonadotropin-releasing hormone receptor in the brain and pituitary of the European sea bass: an in situ hybridization study. Biol Reprod 2004; 70: 1380-1391.
    • (2004) Biol Reprod , vol.70 , pp. 1380-1391
    • González-Martínez, D.1    Madigou, T.2    Mañanos, E.3    Cerdá-Reverter, J.M.4    Zanuy, S.5    Kah, O.6    Muñoz-Cueto, J.A.7
  • 50
    • 77953163638 scopus 로고    scopus 로고
    • The Highly conserved gonadotropin-releasing hormone-2 form acts as a melatonin-releasing factor in the pineal of a teleost fish, the European sea bass Dicentrarchus labrax
    • Servili A, Lethimonier C, Lareyre JJ, López-Olmeda JF, Sánchez-Vázquez FJ, Kah O, Muñoz-Cueto JA: The Highly conserved gonadotropin-releasing hormone-2 form acts as a melatonin-releasing factor in the pineal of a teleost fish, the European sea bass Dicentrarchus labrax . Endocrinology 2010; 151: 2265-2275.
    • (2010) Endocrinology , vol.151 , pp. 2265-2275
    • Servili, A.1    Lethimonier, C.2    Lareyre, J.J.3    López-Olmeda, J.F.4    Sánchez-Vázquez, F.J.5    Kah, O.6    Muñoz-Cueto, J.A.7
  • 51
    • 0038292986 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone increases melatonin release in the pineal gland of the female rat in vitro
    • Itoh MT, Hosaka T, Mimuro T, Hamada N, Ishizuka B: Gonadotropin-releasing hormone increases melatonin release in the pineal gland of the female rat in vitro. Horm Metab Res 2003; 35: 153-157.
    • (2003) Horm Metab Res , vol.35 , pp. 153-157
    • Itoh, M.T.1    Hosaka, T.2    Mimuro, T.3    Hamada, N.4    Ishizuka, B.5
  • 52
    • 0029062213 scopus 로고
    • Characterization of gonadotropin-releasing hormone-immunoreactive protein in the rat pineal gland
    • Park MK, Kogo H, Kawashima S, Wakabayashi K: Characterization of gonadotropin-releasing hormone-immunoreactive protein in the rat pineal gland. J Neurosci Res 1995; 41: 386-393.
    • (1995) J Neurosci Res , vol.41 , pp. 386-393
    • Park, M.K.1    Kogo, H.2    Kawashima, S.3    Wakabayashi, K.4
  • 53
    • 0030729196 scopus 로고    scopus 로고
    • Simultaneous measurement of gonadotropin-releasing hormone in the third ventricular cerebrospinal fluid and hypophyseal portal blood of the ewe
    • Skinner DC, Caraty A, Malpaux B, Evans NP: Simultaneous measurement of gonadotropin-releasing hormone in the third ventricular cerebrospinal fluid and hypophyseal portal blood of the ewe. Endocrinology 1997; 138: 4699-4704.
    • (1997) Endocrinology , vol.138 , pp. 4699-4704
    • Skinner, D.C.1    Caraty, A.2    Malpaux, B.3    Evans, N.P.4
  • 54
    • 53349121028 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone in third ventricular cerebrospinal fluid: Endogenous distribution and exogenous uptake
    • Caraty A, Skinner DC: Gonadotropin-releasing hormone in third ventricular cerebrospinal fluid: endogenous distribution and exogenous uptake. Endocrinology 2008; 149: 5227-5234.
    • (2008) Endocrinology , vol.149 , pp. 5227-5234
    • Caraty, A.1    Skinner, D.C.2
  • 55
    • 34347356449 scopus 로고    scopus 로고
    • Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat
    • Rath MF, Morin F, Shi Q, Klein DC, Møller M: Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat. Exp Eye Res 2007; 85: 65-73.
    • (2007) Exp Eye Res , vol.85 , pp. 65-73
    • Rath, M.F.1    Morin, F.2    Shi, Q.3    Klein, D.C.4    Møller, M.5
  • 56
    • 34447518530 scopus 로고    scopus 로고
    • Molecular physiology of pituitary development: Signaling and transcriptional networks
    • Zhu X, Gleiberman AS, Rosenfeld MG: Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev 2007; 87: 933-963.
    • (2007) Physiol Rev , vol.87 , pp. 933-963
    • Zhu, X.1    Gleiberman, A.S.2    Rosenfeld, M.G.3
  • 57
    • 67650527155 scopus 로고    scopus 로고
    • Otx2: Induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors
    • Larder R, Mellon PL: Otx2: induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem 2009; 284: 16966-16978.
    • (2009) J Biol Chem , vol.284 , pp. 16966-16978
    • Larder, R.1    Mellon, P.L.2
  • 58
    • 0038621817 scopus 로고    scopus 로고
    • Generation of the melatonin endocrine message in mammals: A review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters
    • Simonneaux V, Ribelayga C: Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 2003; 55: 325-395.
    • (2003) Pharmacol Rev , vol.55 , pp. 325-395
    • Simonneaux, V.1    Ribelayga, C.2


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