Xanthorrhizol induces apoptosis through ROS-mediated MAPK activation in human oral squamous cell carcinoma cells and inhibits DMBA-induced oral carcinogenesis in hamsters

Phytotherapy Research

Volumn 27, Issue 4, 2013, Pages 493-498

  Kim, Ju Yeon ^a   An, Jeong Mi ^a   Chung, Won Yoon ^a   Park, Kwang Kyun ^a   Hwang, Jae Kwan ^b   Kim, Du Sik ^a   Seo, Su Ryeon ^c   Seo, Jeong Taeg ^a  

^a Yonsei University College of Dentistry   (South Korea)

^b Yonsei University   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

caspases; MAPKs; oral squamous cell carcinoma cells; PARP; ROS; xanthorrhizol

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; CALCIUM; CASPASE INHIBITOR; DIMETHYLBENZ[A]ANTHRACENE; EGTAZIC ACID; GLUTATHIONE; HYDROXYL RADICAL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NORPHENAZONE; REACTIVE OXYGEN METABOLITE; SESQUITERPENOID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; XANTHORRHIZOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CARCINOMA CELL; CELL STRAIN; CELL STRAIN SCC 15; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME DEGRADATION; HAMSTER; HUMAN; HUMAN CELL; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN; SURVIVAL RATE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE INHIBITORS; CELL LINE, TUMOR; CELL SURVIVAL; CRICETINAE; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MOUTH NEOPLASMS; NEOPLASMS, EXPERIMENTAL; PHENOLS; REACTIVE OXYGEN SPECIES;

CRICETINAE; CURCUMA XANTHORRHIZA;

EID: 84876283265     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4746     Document Type: Article

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