Inhalation injury: Epidemiology, pathology, treatment strategies

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Volumn 21, Issue 1, 2013, Pages

  Dries, David J ^a   Endorf, Frederick W ^a  

^a REGIONS HOSPITAL   (United States)

Author keywords

Bronchoscopy; Burns; Carbon monoxide; Cyanide; Smoke inhalation

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARBOXYHEMOGLOBIN; CYANIDE; HEMOGLOBIN;

ARTIFICIAL VENTILATION; BRONCHOSCOPY; BURN; CARBON MONOXIDE INTOXICATION; DRUG EFFECT; HUMAN; HYPERBARIC OXYGEN; LUNG BURN; LUNG CIRCULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; REVIEW; CARBON MONOXIDE POISONING; DRUG EFFECTS; SMOKE INHALATION INJURY;

ADRENERGIC BETA-AGONISTS; ANTI-INFLAMMATORY AGENTS; BRONCHOSCOPY; BURNS; CARBON MONOXIDE POISONING; CARBOXYHEMOGLOBIN; CYANIDES; HEMOGLOBINS; HUMANS; HYPERBARIC OXYGENATION; POSITIVE-PRESSURE RESPIRATION; PULMONARY CIRCULATION; RESPIRATION, ARTIFICIAL; SMOKE INHALATION INJURY;

EID: 84876283196     PISSN: None     EISSN: 17577241     Source Type: Journal    
DOI: 10.1186/1757-7241-21-31     Document Type: Review

References (121)

1. Park GY, Park JW, Jeong DH, Jeong SW. Prolonged airway and systemic inflammatory reactions after smoke inhalation. Chest 2003, 123:475-480. 10.1378/chest.123.2.475, 12576369.
2. Palmieri TL. Inhalation injury: research progress and needs. J Burn Care Res 2007, 28:549-554. 10.1097/BCR.0B013E318093DEF0, 17502839.
3. McCall JE, Cahill TJ. Respiratory care of the burn patient. J Burn Care Rehabil 2005, 26:200-206.
4. Navar PD, Saffle JR, Warden GD. Effect of inhalation injury on fluid resuscitation requirements after thermal injury. Am J Surg 1985, 150:716-720. 10.1016/0002-9610(85)90415-5, 4073365.
5. Shirani KZ, Pruitt BA, Mason AD. The influence of inhalation injury and pneumonia on burn mortality. Ann Surg 1987, 205:82-87. 10.1097/00000658-198701000-00015, 1492872, 3800465.
6. Sen S, Greenhalgh D, Palmieri T. Review of burn research for the year 2010. J Burn Care Res 2012, 33:577-586. 10.1097/BCR.0b013e3182644fba, 22878497.
7. Colohan SM. Predicting prognosis in thermal burns with associated inhalational injury: a systematic review of prognostic factors in adult burn victims. J Burn Care Res 2010, 31:529-539. 10.1097/BCR.0b013e3181e4d680, 20523229.
8. Hassan Z, Wong JK, Bush J, Bayat A, Dunn KW. Assessing the severity of inhalation injuries in adults. Burns 2010, 36:212-216. 10.1016/j.burns.2009.06.205, 20006445.
9. Woodson LC. Diagnosis and grading of inhalation injury. J Burn Care Res 2009, 30:143-145. 10.1097/BCR.0b013e3181923b71, 19060739.
10. Enkhbaatar P, Traber DL. Pathophysiology of acute lung injury in combined burn and smoke inhalation injury. Clin Sci 2004, 107:137-143. 10.1042/CS20040135, 15151496.
11. Sheridan RL. Respiratory issues. Burns: A Practical Approach to Immediate Treatment and Long-Term Care 2012, 48-54. London: Mason Publishing Ltd.
12. Pruitt BA, Flemma RJ, DiVincenti FC, Foley FD, Mason AD, Young WG. Pulmonary complications in burn patients. A comparative study of 697 patients. J Thorac Cardiovasc Surg 1970, 59:7-20.
13. Fein A, Leff A, Hopewell PC. Pathophysiology and management of the complications resulting from fire and the inhaled products of combustion: review of the literature. Crit Care Med 1980, 8:94-98. 10.1097/00003246-198002000-00008, 7353393.
14. Herndon DN, Thompson PB, Traber DL. Pulmonary injury in burned patients. Crit Care Clin 1985, 1:79-96.
15. Herndon DN, Traber LD, Linares H, Flynn JD, Niehaus G, Kramer G, Traber DL. Etiology of the pulmonary pathophysiology associated with inhalation injury. Resuscitation 1986, 14:43-59. 10.1016/0300-9572(86)90006-7, 3024279.
16. Pruitt BA, Erickson DR, Morris A. Progressive pulmonary insufficiency and other pulmonary complications of thermal injury. J Trauma 1975, 15:369-379.
17. Rue LW, Cioffi WG, Mason AD, McManus WF, Pruitt BA. Improved survival of burned patients with inhalation injury. Arch Surg 1993, 128:772-780. 10.1001/archsurg.1993.01420190066009, 8317959.
18. Madden MR, Finkelstein JL, Goodwin CW. Respiratory care of the burn patient. Clin Plast Surg 1986, 13:29-38.
19. Trunkey DD. Inhalation injury. Surg Clin North Am 1978, 58:1133-1140.
20. Goldbaum LR, Orellano T, Dergal E. Mechanism of the toxic action of carbon monoxide. Ann Clin Lab Sci 1976, 6:372-376.
21. Moore SJ, Ho IK, Hume AS. Severe hypoxia produced by concomitant intoxication with sublethal doses of carbon monoxide and cyanide. Toxicol Appl Pharmacol 1991, 109:412-420. 10.1016/0041-008X(91)90004-X, 1853342.
22. Palmieri TL, Gamelli RL. Diagnosis and management of inhalation injury. Handbook of Burns, Volume 1, Acute Burn Care 2012, 163-172. New York: Springer.
23. Crapo RO. Smoke inhalation injuries. JAMA 1981, 246:1694-1696. 10.1001/jama.1981.03320150042027, 7277645.
24. Grube BJ, Marvin JA, Heimbach DM. Therapeutic hyperbaric oxygen: Help or hindrance in burn patients with carbon monoxide poisoning. J Burn Care Rehabil 1988, 9:249-252.
25. Endorf FW, Gamelli RL. Inhalation injury, pulmonary perturbations, and fluid resuscitation. J Burn Care Res 2007, 28:80-83. 10.1097/BCR.0B013E31802C889F, 17211205.
26. Palmieri TL, Klein MB. Burn research state of the science: introduction. J Burn Care Res 2007, 28:544-545. 10.1097/BCR.0b013e318095a40f, 17514024.
27. Dai NT, Chen TM, Cheng TY, Chen SL, Chen SG, Chou GH, Chou TD, Wang HJ. The comparison of early fluid therapy in extensive flame burns between inhalation and noninhalation injuries. Burns 1998, 24:671-675. 10.1016/S0305-4179(98)00092-8, 9882069.
28. Brown DL, Archer SB, Greenhalgh DG, Washam MA, James LE, Warden GD. Inhalation injury severity scoring system: a quantitative method. J Burn Care Rehabil 1996, 17:552-557. 10.1097/00004630-199611000-00013, 8951544.
29. Liffner G, Bak Z, Reske A, Sjoberg F. Inhalation injury assessed by score does not contribute to the development of acute respiratory distress syndrome in burn victims. Burns 2005, 31:263-268. 10.1016/j.burns.2004.11.003, 15774279.
30. Marek K, Piotr W, Stanislaw S, Stefan G, Justyna G, Mariusz N, Andriessen A. Fiberoptic bronchoscopy in routine clinical practice in confirming the diagnosis and treatment of inhalation burns. Burns 2007, 33:554-560. 10.1016/j.burns.2006.08.030, 17376597.
31. Masanes MJ, Legendre C, Lioret N, Maillard D, Saizy R, Lebeau B. Fiberoptic bronchoscopy for the early diagnosis of subglottal inhalation injury: Comparative value in the assessment of prognosis. J Trauma 1994, 36:59-67. 10.1097/00005373-199401000-00009, 8295250.
32. Cochrane Collaboration Evidence based surgery-inhalation injury: diagnosis. J Am Coll Surg 2003, 196:306-312. Cochrane Collaboration.
33. Carr JA, Phillips BD, Bowling WM. The utility of bronchoscopy after inhalation injury complicated by pneumonia in burn patients: results from the national burn repository. J Burn Care Res 2009, 30:967-974.
34. Arakawa A, Fukamizu H, Hashizume I, Kasamatsu N, Nagayoshi M, Shinozuka N, Yasuda T, Ozawa T. Macroscopic and histological findings in the healing process of inhalation injury. Burns 2007, 33:855-859. 10.1016/j.burns.2006.10.405, 17521820.
35. Mosier MJ, Gamelli RL, Halerz MM, Silver G. Microbial contamination in burn patients undergoing urgent intubation as part of their early airway management. J Burn Care Res 2008, 29:304-310. 10.1097/BCR.0b013e318166daa5, 18354286.
36. Kealey GP. Carbon monoxide toxicity. J Burn Care Res 2009, 30:146-147. 10.1097/BCR.0b013e3181923b81, 19060737.
37. Weaver LK. Clinical practice. Carbon monoxide poisoning. N Engl J Med 2009, 360:1217-1225. 10.1056/NEJMcp0808891, 19297574.
38. Hardy KR, Thom SR. Pathophysiology and treatment of carbon monoxide poisoning. J Toxicol Clin Toxicol 1994, 32:613-629. 10.3109/15563659409017973, 7966524.
39. Jasper BW, Hopkins RO, Duker HV, Weaver LK. Affective outcome following carbon monoxide poisoning: a prospective longitudinal study. Cogn Behav Neurol 2005, 18:127-134. 10.1097/01.wnn.0000160820.07836.cf, 15970733.
40. Ernst A, Zibrak JD. Carbon monoxide poisoning. N Engl J Med 1998, 339:1603-1608. 10.1056/NEJM199811263392206, 9828249.
41. Gale SD, Hopkins RO, Weaver LK, Bigler ED, Booth EJ, Blatter DD. MRI, quantitative MRI, SPECT, and neuropsychological findings following carbon monoxide poisoning. Brain Inj 1999, 13:229-243. 10.1080/026990599121601, 10230524.
42. Choi IS. Delayed neurologic sequelae in carbon monoxide intoxication. Arch Neurol 1983, 40:433-435. 10.1001/archneur.1983.04050070063016, 6860181.
43. Weaver LK. Carbon monoxide poisoning. Crit Care Clin 1999, 15:297-317. 10.1016/S0749-0704(05)70056-7, 10331130.
44. Hampson NB, Hauff NM. Carboxyhemoglobin levels in carbon monoxide poisoning: Do they correlate with the clinical picture?. Am J Emerg Med 2008, 26:665-669. 10.1016/j.ajem.2007.10.005, 18606318.
45. Satran D, Henry CR, Adkinson C, Nicholson CI, Bracha Y, Henry TD. Cardiovascular manifestations of moderate to severe carbon monoxide poisoning. J Am Coll Cardiol 2005, 45:1513-1516. 10.1016/j.jacc.2005.01.044, 15862427.
46. Kalay N, Ozdogru I, Cetinkaya Y, Eryol NK, Dogan A, Gul I, Inanc T, Ikizceli I, Oguzhan A, Abaci A. Cardiovascular effects of carbon monoxide poisoning. Am J Cardiol 2007, 99:322-324. 10.1016/j.amjcard.2006.08.030, 17261390.
47. Thom SR. Carbon monoxide pathophysiology and treatment. Physiology and Medicine of Hyperbaric Oxygen Therapy 2008, 321-347. Philadelphia: Saunders Elsevier, Newman TS, Thom SR.
48. Thom SR, Taber RL, Mendiguren II, Clark JM, Hardy KR, Fisher AB. Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 1995, 25:474-480. 10.1016/S0196-0644(95)70261-X, 7710151.
49. Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF, Thomas FO, Morris AH. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002, 347:1057-1067. 10.1056/NEJMoa013121, 12362006.
50. Weaver LK, Valentine KJ, Hopkins RO. Carbon monoxide poisoning: risk factors for cognitive sequelae and the role of hyperbaric oxygen. Am J Respir Crit Care Med 2007, 176:491-497. 10.1164/rccm.200701-026OC, 17496229.
51. Brooks DE, Levine M, O'Connor AD, French RN, Curry SC. Toxicology in the ICU: part 2: specific toxins. Chest 2011, 140:1072-1085. 10.1378/chest.10-2726, 21972388.
52. Annane D, Chadda K, Gajdos P, Jars-Guincestre MC, Chevret S, Raphael JC. Hyperbaric oxygen therapy for acute domestic carbon monoxide poisoning: Two randomized controlled trials. Intensive Care Med 2011, 37:486-492. 10.1007/s00134-010-2093-0, 21125215.
53. Juurlink DN, Buckley NA, Stanbrook MB, Isbister GK, Bennett M, McGuigan MA. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev 2005, 1. CD002041.
54. Buckley NA, Juurlink DN, Isbister G, Bennett MH, Lavonas EJ. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev 2011, 4. CD002041.
55. Hampson NB, Rudd RA, Hauff NM. Increased long-term mortality among survivors of acute carbon monoxide poisoning. Crit Care Med 2009, 37:1941-1947. 10.1097/CCM.0b013e3181a0064f, 19384195.
56. Traber DL, Herndon DN, Enkhbaatar P, Maybauer MO, Maybauer DM. The pathophysiology of inhalation injury. Total Burn Care 2007, 248-261. Philadelphia: Saunders Elsevier, 3.
57. Barillo DJ. Diagnosis and treatment of cyanide toxicity. J Burn Care Res 2009, 30:148-152. 10.1097/BCR.0b013e3181923b91, 19060738.
58. Barillo DJ, Goode R, Esch V. Cyanide poisoning in victims of fire: analysis of 364 cases and review of the literature. J Burn Care Rehabil 1994, 15:46-57. 10.1097/00004630-199401000-00010, 8150843.
59. Berlin C. Cyanide poisoning-a challenge (editorial). Arch Intern Med 1977, 137:993-994. 10.1001/archinte.1977.03630200003003, 879954.
60. Ivankovich AD, Braverman B, Kanuru RP, Heyman HJ, Paulissian R. Cyanide antidotes and methods of their administration in dogs: a comparative study. Anesthesiology 1980, 52:210-216. 10.1097/00000542-198003000-00004, 7369507.
61. Levine MS, Radford EP. Occupational exposures to cyanide in Baltimore fire fights. J Occup Med 1978, 20:53-56. 10.1097/00043764-197801000-00011, 202686.
62. Graham DL, Laman D, Theodore J, Robin ED. Acute cyanide poisoning complicated by lactic acidosis and pulmonary edema. Arch Intern Med 1977, 137:1051-1055. 10.1001/archinte.1977.03630200055016, 879942.
63. Hall AH, Dart R, Bogdan G. Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning?. Ann Emerg Med 2007, 49:806-813. 10.1016/j.annemergmed.2006.09.021, 17098327.
64. Langford RM, Armstrong RF. Algorithm for managing injury from smoke inhalation. BMJ 1989, 299:902-905. 10.1136/bmj.299.6704.902, 1837762, 2510883.
65. Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann Emerg Med 1986, 15:1067-1074. 10.1016/S0196-0644(86)80131-7, 3526995.
66. Davies J. Challenges for the future. Respiratory injury: smoke inhalation and burns 1990, 389. New York: McGraw Hill, Haponik EF, Munster AM.
67. Hall AH, Saiers J, Baud F. Which cyanide antidote?. Crit Rev Toxicol 2009, 39:541-552. 10.1080/10408440802304944, 19650716.
68. O'Brien DJ, Walsh DW, Terriff CM, Hall AH. Empiric management of cyanide toxicity associated with smoke inhalation. Prehosp Disaster Med 2011, 26:374-382. 10.1017/S1049023X11006625, 22336184.
69. Erdman AR. Is hydroxocobalamin safe and effective for smoke inhalation? Searching for guidance in the haze. Ann Emerg Med 2007, 49:814-816. 10.1016/j.annemergmed.2007.03.006, 17512866.
70. Litovitz TL, Larkin RF, Myers RA. Cyanide poisoning treated with hyperbaric oxygen. Am J Emerg Med 1983, 1:94-101. 10.1016/0735-6757(83)90041-4, 6680611.
71. Way JL, End E, Sheehy MH, De Miranda P, Feitknecht UF, Bachand R, Gibbon SL, Burrows GE. Effect of oxygen on cyanide intoxication IV. Hyperbaric oxygen. Toxicol Appl Pharmacol 1972, 22:415-421. 10.1016/0041-008X(72)90247-5, 5041371.
72. Grube BJ. Therapeutic hyperbaric oxygen: help or hindrance in burn patients with carbon monoxide poisoning?. J Burn Care Rehabil 1989, 10:285.
73. Cohen MA, Guzzardi LJ. Inhalation of products of combustion. Ann Emerg Med 1983, 12:628-632. 10.1016/S0196-0644(83)80209-1, 6625265.
74. Mlcak RP, Suman OE, Herndon DN. Respiratory management of inhalation injury. Burns 2007, 33:2-13. 10.1016/j.burns.2006.07.007, 17223484.
75. Latenser BA. Critical care of the burn patient: the first 48 hours. Crit Care Med 2009, 37:2819-2826. 10.1097/CCM.0b013e3181b3a08f, 19707133.
76. Noah MA, Peek GJ, Finney SJ, Griffiths MJ, Harrison DA, Grieve R, Sadique MZ, Sekhon JS, McAuley DF, Firmin RK, Harvey C, Cordingley JJ, Price S, Vuylsteke A, Jenkins DP, Noble DW, Bloomfield R, Walsh TS, Perkins GD, Menon D, Taylor BL, Rowan KM. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1). JAMA 2011, 306:1659-1668. 10.1001/jama.2011.1471, 21976615.
77. Thompson JT, Molnar JA, Hines MH, Chang MC, Pranikoff T. Successful management of adult smoke inhalation with extracorporeal membrane oxygenation. J Burn Care Rehabil 2005, 26:62-66. 10.1097/01.BCR.0000150303.15345.79, 15640737.
78. Hale DF, Cannon JW, Batchinsky AI, Cancio LC, Aden JK, White CE, Renz EM, Blackbourne LH, Chung KK. Prone positioning improves oxygenation in adult burn patients with severe acute respiratory distress syndrome. J Trauma Acute Care Surg 2012, 72:1634-1639. 10.1097/TA.0b013e318247cd4f, 22695433.
79. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO, the OSCILLATE Trial Investigators High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 2013, Epub, the OSCILLATE Trial Investigators.
80. Young D, Lamb SE, Shah S, Mackenzie I, Tunnicliffe W, Lall R, Rowan K, Phil D, Cuthbertson BH, the OSCAR Study Group High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 2013, Epub, the OSCAR Study Group.
81. Malhotra A, Drazen JM. High-frequency ventilation on shaky ground. N Engl J Med 2013, Epub.
82. Dries DJ. Key questions in ventilator management of the burn-injury patient (Second of two parts). J Burn Care Res 2009, 30:211-220. 10.1097/BCR.0b013e318198a33f, 19165105.
83. Dries DJ, Marini JJ. Airway pressure release ventilation. J Burn Care Res 2009, 30:929-936.
84. Endorf FW, Dries DJ. Noninvasive ventilation in the burned patient. J Burn Care Res 2010, 31:217-228. 10.1097/BCR.0b013e3181d0f62c, 20182360.
85. Brochard L. Noninvasive ventilation for acute respiratory failure. JAMA 2002, 288:932-935. 10.1001/jama.288.8.932, 12190351.
86. Dries DJ. Permissive hypercapnia. J Trauma 1995, 39:984-989. 10.1097/00005373-199511000-00028, 7474020.
87. Gattinoni L, Presenti A, Torresin A, Baglioni S, Rivolta M, Rossi F, Scarani F, Marcolin R, Cappelletti G. Adult respiratory distress syndrome profiles by computed tomography. J Thorac Imaging 1986, 1:25-30. 10.1097/00005382-198607000-00005, 3612906.
88. West JB. Respiratory physiology-the essentials 1980, Baltimore: Williams & Wilkins.
89. Dries DJ. Key questions in ventilator management of the burn-injured patient (First of two parts). J Burn Care Res 2009, 30:128-138. 10.1097/BCR.0b013e318191fe44, 19180696.
90. Feihl F, Perret C. Permissive hypercapnia. How permissive should we be?. Am J Respir Crit Care Med 1994, 150:1722-1737. 10.1164/ajrccm.150.6.7952641, 7952641.
91. Wang Z, Su F, Bruhn A, Yang X, Vincent JL. Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock. Am J Respir Crit Care Med 2008, 177:178-183. 10.1164/rccm.200706-906OC, 17947612.
92. Ebata T, Watanabe Y, Amaha K, Hosaka Y, Takagi S. Haemodynamic changes during the apnoea test for diagnosis of brain death. Can J Anaesth 1991, 38:436-440. 10.1007/BF03007579, 1905987.
93. Malbouisson LM, Muller JC, Constantin JM, Lu Q, Puybasset L, Rouby JJ. CT Scan ARDS Study Group. Computed tomography assessment of positive end-expiratory pressure-induced alveolar recruitment in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2001, 163:1444-1450. 10.1164/ajrccm.163.6.2005001, 11371416.
94. Navalesi P, Maggiore SM. Positive end-expiratory pressure. Principles & Practice of Mechanical Ventilation 2013, 253-302. New York: McGraw-Hill, Tobin MJ, 3, 3640244, 23661883.
95. Jonson B, Richard JC, Straus C, Mancebo J, Lemaire F, Brochard L. Pressure-volume curves and compliance in acute lung injury: evidence of recruitment above the lower inflection point. Am J Respir Crit Care Med 1999, 159:1172-1178. 10.1164/ajrccm.159.4.9801088, 10194162.
96. Marini JJ. Dynamic hyperinflation and auto-positive end-expiratory pressure: lessons learned over 30 years. Am J Respir Crit Care Med 2011, 184:756-762. 10.1164/rccm.201102-0226PP, 21700908.
97. Stalcup SA, Mellins RB. Mechanical forces producing pulmonary edema in acute asthma. N Engl J Med 1977, 297:592-596. 10.1056/NEJM197709152971107, 887117.
98. Hall JJ, Hunt JL, Arnoldo BD, Purdue GF. Use of high-frequency percussive ventilation in inhalation injuries. J Burn Care Res 2007, 28:396-400. 10.1097/BCR.0B013E318053D2D6, 17438509.
99. Cioffi WG, Rue LW, Graves TA, McManus WF, Mason AD, Pruitt BA. Prophylactic use of high-frequency percussive ventilation in patients with inhalation injury. Ann Surg 1991, 213:575-582. 10.1097/00000658-199106000-00007, 1358579, 2039288.
100. Chung KK, Wolf SE, Renz EM, Allan PF, Aden JK, Merrill GA, Shelhamer MC, King BT, White CE, Bell DG, Schwacha MG, Wanek SM, Wade CE, Holcomb JB, Blackbourne LH, Cancio LC. High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial. Crit Care Med 2010, 38:1970-1977.
101. Allan PF, Osborn EC, Chung KK, Wanek SM. High-frequency percussive ventilation revisited. J Burn Care Res 2010, 31:510-520. 10.1097/BCR.0b013e3181e4d605, 20616646.
102. Lange M, Hamahata A, Traber DL, Cox RA, Kulp GA, Nakano Y, Traber LD, Herndon DN, Enkhbaatar P. Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury. Crit Care Med 2011, 39:718-724. 10.1097/CCM.0b013e318207ec52, 21263320.
103. Palmieri T, Enkhbaatar P, Bayliss R, Traber LD, Cox RA, Hawkins HK, Herndon DN, Greenhalgh DG, Traber DL. Continuous nebulized albuterol attenuates acute lung injury in an ovine model of combined burn and smoke inhalation. Crit Care Med 2006, 34:1719-1724.
104. Hamahata A, Enkhbaatar P, Sakurai H, Nozaki M, Traber DL. Effect of ablated bronchial blood flow on survival rate and pulmonary function after burn and smoke inhalation in sheep. Burns 2009, 35:802-810. 10.1016/j.burns.2008.12.013, 2739875, 19303716.
105. Hamahata A, Enkhbaatar P, Sakurai H, Nozaki M, Traber DL. Sclerosis therapy of bronchial artery attenuates acute lung injury induced by burn and smoke inhalation injury in ovine model. Burns 2010, 36:1042-1049. 10.1016/j.burns.2009.05.016, 2904424, 20381969.
106. Zamanian RT, Haddad F, Doyle RL, Weinacker AB. Management strategies for patients with pulmonary hypertension in the intensive care unit. Crit Care Med 2007, 35:2037-2050. 10.1097/01.CCM.0000280433.74246.9E, 17855818.
107. Enkhbaatar P, Kikuchi Y, Traber LD, Westphal M, Morita N, Maybauer MO, Maybauer DM, Herndon DN, Traber DL. Effect of inhaled nitric oxide on pulmonary vascular hyperpermeability in sheep following smoke inhalation. Burns 2005, 31:1013-1019. 10.1016/j.burns.2005.06.021, 16288960.
108. Qi S, Sun W. The effects of inhaled nitric oxide on cardiac pathology and energy metabolism in a canine model of smoke inhalation injury. Burns 2004, 30:65-71. 10.1016/j.burns.2003.09.017, 14693088.
109. Enkhbaatar P, Murakami K, Cox R, Westphal M, Morita N, Brantley K, Burke A, Hawkins H, Schmalstieg F, Traber L, Herndon D, Traber D. Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation. Shock 2004, 22:70-75. 10.1097/01.shk.0000129201.38588.85, 15201705.
110. Enkhbaatar P, Cox RA, Traber LD, Westphal M, Aimalohi E, Morita N, Prough DS, Herndon DN, Traber DL. Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation. Crit Care Med 2007, 35:2805-2810. 10.1097/01.CCM.0000291647.18329.83, 18074480.
111. Desai MH, Mlcak R, Richardson J, Nichols R, Herndon DN. Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin/N-acetylcystine therapy. J Burn Care Rehabil 1998, 19:210-212. 10.1097/00004630-199805000-00004, 9622463.
112. Holt J, Saffle JR, Morris SE, Cochran A. Use of inhaled heparin/N-acetylcystine in inhalation injury: does it help?. J Burn Care Res 2008, 29:192-195.
113. Chopra A, Burkey B, Calaman S. A case report of clinically significant coagulopathy associated with aerosolized heparin and acetylcysteine therapy for inhalation injury. Burns 2011, 37:e73-e75. 10.1016/j.burns.2011.07.019, 21852049.
114. Tasaki O, Mozingo DW, Dubick MA, Goodwin CW, Yantis LD, Pruitt BA. Effects of heparin and lisofylline on pulmonary function after smoke inhalation injury in an ovine model. Crit Care Med 2002, 30:637-643. 10.1097/00003246-200203000-00024, 11998809.
115. Sprague RS, Stephenson AH, Lonigro AJ. OKY-046 prevents increases in LTB4 and pulmonary edema in phorbol ester-induced lung injury in dogs. J Appl Physiol 1992, 73:2493-2498.
116. Ishitsuka Y, Moriuchi H, Hatamoto K, Yang C, Takase J, Golbidi S, Irikura M, Irie T. Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor in guinea-pigs. J Pharm Pharmacol 2004, 56:513-520. 10.1211/0022357023150, 15099446.
117. Westphal M, Noshima S, Isago T, Fujioka K, Maybauer MO, Maybauer DM, Traber LD, Flynn JT, Westphal-Varghese BB, Traber DL. Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury. Anesthesiology 2005, 102:954-961. 10.1097/00000542-200505000-00014, 15851882.
118. Yamamoto Y, Enkhbaatar P, Sousse LE, Sakurai H, Rehberg SW, Asmussen S, Kraft ER, Wright CL, Bartha E, Cox RA, Hawkins HK, Traber LD, Traber MG, Szabo C, Herndon DN, Traber DL. Nebulization with gamma-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model. Shock 2012, 37:408-414. 10.1097/SHK.0b013e3182459482, 3306540, 22266978.
119. Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol 2001, 125:129-144. 10.1016/S0034-5687(00)00209-7, 11240157.
120. Buhling F, Lieder N, Kuhlmann UC, Waldburg N, Welte T. Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro. Respir Med 2007, 101:2386-2394. 10.1016/j.rmed.2007.06.009, 17761412.
121. Jonkam C, Zhu Y, Jacob S, Rehberg S, Kraft E, Hamahata A, Nakano Y, Traber LD, Herndon DN, Traber DL, Hawkins HK, Enkhbaatar P, Cox RA. Muscarinic receptor antagonist therapy improves acute pulmonary dysfunction after smoke inhalation injury in sheep. Crit Care Med 2010, 38:2339-2344. 10.1097/CCM.0b013e3181f8557b, 20838334.