Use of inhaled heparin/N-acetylcystine in inhalation injury: Does it help?

Journal of Burn Care and Research

Volumn 29, Issue 1, 2008, Pages 192-195

  Holt, Joshua ^a   Saffle, Jeffrey R ^a   Morris, Stephen E ^a   Cochran, Amalia ^a,b  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; HEPARIN; SALBUTAMOL;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DATA BASE; FEMALE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; LUNG BURN; LUNG MECHANICS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; OXYGEN TENSION; RETROSPECTIVE STUDY; TIME SERIES ANALYSIS;

ADULT; BURN UNITS; CYSTINE; DATABASES AS TOPIC; FEMALE; HEPARIN; HUMANS; INCIDENCE; LENGTH OF STAY; MALE; SEVERITY OF ILLNESS INDEX; SICKNESS IMPACT PROFILE; SMOKE INHALATION INJURY; TREATMENT OUTCOME;

EID: 38049048042     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e31815f596b     Document Type: Article

References (8)

1. Desai M, Mlcak R, Richardson J, Nichols R, Herndon D. Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin/acetylcystine therapy. J Burn Care Rehabil 1998;19:210-2.
2. Linares H, Herndon D, Traber D. Sequence of morphologic events in experimental smoke inhalation. J Burn Care Rehabil 1989;27-37.
3. Isago T, Noshima S, Traber L, Herndon D, Traber D. Analysis of pulmonary microvascular permeability after smoke inhalation. J Appl Physiol 1991;71:1403-8.
4. Herndon D, Thompson P, Traber D, et al. Diagnosis, pathophysiology and treatment of inhalation injury: the art and science of burn care. Baltimore: University Press; 1987.
5. De Maestro R, Thaw L, Bjork T, et al. Free radicals as mediators of tissue injury. Acta Physiol Scand 1980;192(suppl):13-57.
6. Cox C, Zwischenberger J, Traber D, Traber L, Haque A, Herndon D. Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model. Surg Gynecol Obstet 1993;176:339-49.
7. Brown M, Desai M, Traber L, Herndon D, Traber D. Dimethyl sulfoxide with heparin in the treatment of smoke inhalation injury. J Burn Care Rehabil 1988;9:22-3.
8. Cuzzocrea S, Mazzon E, Dugo L, et al. Protective effects of N-acetylcystine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J 2001;15:1187-200.