Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Kong, Lingbo ^a   Yang, Chongfei ^a   Yu, Lifeng ^a   Smith, Wanli ^b   Zhu, Shu ^a   Zhu, Jinyu ^a   Zhu, Qingsheng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; PYRROLOQUINOLINEQUINONE; QUININE; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BONE EROSION; BONE MARROW CELL; CALVARIA; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN EXPRESSION; RAT;

ACID PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CELL DEATH; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; ISOENZYMES; MICE; MICE, INBRED C57BL; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; OSTEOGENESIS; OSTEOLYSIS; POLYETHYLENES; PROTO-ONCOGENE PROTEINS C-FOS; PYRROLES; QUININE; QUINOLINES; RANK LIGAND; RNA, MESSENGER; SKULL; X-RAY MICROTOMOGRAPHY;

MURINAE; MUS;

EID: 84876279937     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061013     Document Type: Article

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