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Volumn 8, Issue , 2013, Pages 1393-1402

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Author keywords

Delivery system; Epigenetic therapy; Histone deacetylase inhibitor; Iron oxide; Microspheres; Sulforaphane

Indexed keywords

BOVINE SERUM ALBUMIN; DRUG CARRIER; HISTONE; IRON OXIDE; IRON OXIDE MICROSPHERE; MICROSPHERE; SULFORAPHANE; UNCLASSIFIED DRUG;

EID: 84876274670     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S43479     Document Type: Article
Times cited : (50)

References (50)
  • 1
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature. 2007;447(7143):396-398.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 2
    • 0242539836 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Momparler RL. Cancer epigenetics. Oncogene. 2003; 22(42): 6479-6483.
    • (2003) Oncogene , vol.22 , Issue.42 , pp. 6479-6483
    • Momparler, R.L.1
  • 3
    • 36549056015 scopus 로고    scopus 로고
    • Epigenetic changes in cancer
    • Gronbaek K, Hother C, Jones PA. Epigenetic changes in cancer. APMIS. 2007;115(10):1039-1059.
    • (2007) APMIS , vol.115 , Issue.10 , pp. 1039-1059
    • Gronbaek, K.1    Hother, C.2    Jones, P.A.3
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006;5(9):769-784.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 6
    • 84859174608 scopus 로고    scopus 로고
    • Histone-modifying enzymes: Regulators of developmental decisions and drivers of human disease
    • Butler JS, Koutelou E, Schibler AC, Dent SY. Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease. Epigenomics. 2012;4(2):163-177.
    • (2012) Epigenomics , vol.4 , Issue.2 , pp. 163-177
    • Butler, J.S.1    Koutelou, E.2    Schibler, A.C.3    Dent, S.Y.4
  • 7
    • 84864434739 scopus 로고    scopus 로고
    • Emerging epigenetic targets and therapies in cancer medicine
    • Popovic R, Licht JD. Emerging epigenetic targets and therapies in cancer medicine. Cancer Discov. 2012;2(5):405-413.
    • (2012) Cancer Discov , vol.2 , Issue.5 , pp. 405-413
    • Popovic, R.1    Licht, J.D.2
  • 8
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429(6990):457-463.
    • (2004) Nature , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 9
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JP, Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood. 2004; 103(5):1635-1640.
    • (2004) Blood , vol.103 , Issue.5 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3
  • 10
    • 77953329903 scopus 로고    scopus 로고
    • Improved tumor-targeting drug delivery and therapeutic efficacy by cationic liposome modified with truncated bFGF peptide
    • Chen X, Wang X, Wang Y, et al. Improved tumor-targeting drug delivery and therapeutic efficacy by cationic liposome modified with truncated bFGF peptide. J Control Release. 145(1):17-25.
    • J Control Release , vol.145 , Issue.1 , pp. 17-25
    • Chen, X.1    Wang, X.2    Wang, Y.3
  • 11
    • 29244489232 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
    • Mamot C, Drummond DC, Noble CO, et al. Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo. Cancer Res. 2005; 65(24):11631-11638.
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11631-11638
    • Mamot, C.1    Drummond, D.C.2    Noble, C.O.3
  • 12
    • 42049110950 scopus 로고    scopus 로고
    • Application of nanotechnology in cancer therapy and imaging
    • Wang X, Yang L, Chen ZG, Shin DM. Application of nanotechnology in cancer therapy and imaging. CA Cancer J Clin. 2008;58(2):97-110.
    • (2008) CA Cancer J Clin , vol.58 , Issue.2 , pp. 97-110
    • Wang, X.1    Yang, L.2    Chen, Z.G.3    Shin, D.M.4
  • 13
    • 79551629919 scopus 로고    scopus 로고
    • Magnetic iron oxide nanoparticles for tumor-targeted therapy
    • Chen B, Wu W, Wang X. Magnetic iron oxide nanoparticles for tumor-targeted therapy. Curr Cancer Drug Targets. 2011;11(2): 184-189.
    • (2011) Curr Cancer Drug Targets , vol.11 , Issue.2 , pp. 184-189
    • Chen, B.1    Wu, W.2    Wang, X.3
  • 14
    • 84861123819 scopus 로고    scopus 로고
    • Biological applications of magnetic nanoparticles
    • Colombo M, Carregal-Romero S, Casula MF, et al. Biological applications of magnetic nanoparticles. Chem Soc Rev. 2012;41(11): 4306-4334.
    • (2012) Chem Soc Rev , vol.41 , Issue.11 , pp. 4306-4334
    • Colombo, M.1    Carregal-Romero, S.2    Casula, M.F.3
  • 15
    • 84857250783 scopus 로고    scopus 로고
    • Gold nanoparticles as novel agents for cancer therapy
    • Jain S, Hirst DG, O'Sullivan JM. Gold nanoparticles as novel agents for cancer therapy. Br J Radiol. 2012;85(1010):101-113.
    • (2012) Br J Radiol , vol.85 , Issue.1010 , pp. 101-113
    • Jain, S.1    Hirst, D.G.2    O'Sullivan, J.M.3
  • 16
    • 80053629789 scopus 로고    scopus 로고
    • Promising approaches in using magnetic nanoparticles in oncology
    • Mikhaylov G, Vasiljeva O. Promising approaches in using magnetic nanoparticles in oncology. Biol Chem. 2011;392(11):955-960.
    • (2011) Biol Chem , vol.392 , Issue.11 , pp. 955-960
    • Mikhaylov, G.1    Vasiljeva, O.2
  • 17
    • 84858615014 scopus 로고    scopus 로고
    • Iron oxide nanoparticles for targeted cancer imaging and diagnostics
    • Rosen JE, Chan L, Shieh DB, Gu FX. Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomedicine. 2012; 8(3):275-290.
    • (2012) Nanomedicine , vol.8 , Issue.3 , pp. 275-290
    • Rosen, J.E.1    Chan, L.2    Shieh, D.B.3    Gu, F.X.4
  • 18
    • 84857860947 scopus 로고    scopus 로고
    • Nanoparticles for cancer therapy using magnetic forces
    • Tietze R, Lyer S, Durr S, Alexiou C. Nanoparticles for cancer therapy using magnetic forces. Nanomedicine (Lond). 2012;7(3):447-457.
    • (2012) Nanomedicine (Lond) , vol.7 , Issue.3 , pp. 447-457
    • Tietze, R.1    Lyer, S.2    Durr, S.3    Alexiou, C.4
  • 19
    • 0028937013 scopus 로고
    • Effective targeting of magnetic radioactive 90Y-microspheres to tumor cells by an externally applied magnetic field. Preliminary in vitro and in vivo results
    • Hafeli UO, Sweeney SM, Beresford BA, Humm JL, Macklis RM. Effective targeting of magnetic radioactive 90Y-microspheres to tumor cells by an externally applied magnetic field. Preliminary in vitro and in vivo results. Nucl Med Biol. 1995;22(2):147-155.
    • (1995) Nucl Med Biol , vol.22 , Issue.2 , pp. 147-155
    • Hafeli, U.O.1    Sweeney, S.M.2    Beresford, B.A.3    Humm, J.L.4    Macklis, R.M.5
  • 20
    • 42549152143 scopus 로고    scopus 로고
    • Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats
    • Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm. 2008;5(2):316-327.
    • (2008) Mol Pharm , vol.5 , Issue.2 , pp. 316-327
    • Jain, T.K.1    Reddy, M.K.2    Morales, M.A.3    Leslie-Pelecky, D.L.4    Labhasetwar, V.5
  • 22
    • 0035747112 scopus 로고    scopus 로고
    • Clinical applications of magnetic drug targeting
    • Lubbe AS, Alexiou C, Bergemann C. Clinical applications of magnetic drug targeting. J Surg Res. 2001;95(2):200-206.
    • (2001) J Surg Res , vol.95 , Issue.2 , pp. 200-206
    • Lubbe, A.S.1    Alexiou, C.2    Bergemann, C.3
  • 23
    • 52449120699 scopus 로고    scopus 로고
    • Preparation and characterization of interferon-loaded magnetic biodegradable microspheres
    • Zhou S, Sun J, Sun L, et al. Preparation and characterization of interferon-loaded magnetic biodegradable microspheres. J Biomed Mater Res B Appl Biomater. 2008;87(1):189-196.
    • (2008) J Biomed Mater Res B Appl Biomater , vol.87 , Issue.1 , pp. 189-196
    • Zhou, S.1    Sun, J.2    Sun, L.3
  • 24
    • 0028486124 scopus 로고
    • Magnetically directed poly(lactic acid) 90Y-microspheres: Novel agents for targeted intracavitary radiotherapy
    • Hafeli UO, Sweeney SM, Beresford BA, Sim EH, Macklis RM. Magnetically directed poly(lactic acid) 90Y-microspheres: novel agents for targeted intracavitary radiotherapy. J Biomed Mater Res. 1994; 28(8):901-908.
    • (1994) J Biomed Mater Res , vol.28 , Issue.8 , pp. 901-908
    • Hafeli, U.O.1    Sweeney, S.M.2    Beresford, B.A.3    Sim, E.H.4    Macklis, R.M.5
  • 25
    • 57149125463 scopus 로고    scopus 로고
    • Optimizing magnetic nanoparticle design for nanothermotherapy
    • Gazeau F, Levy M, Wilhelm C. Optimizing magnetic nanoparticle design for nanothermotherapy. Nanomeicine (Lond). 2008;3(6):831-844.
    • (2008) Nanomeicine (Lond) , vol.3 , Issue.6 , pp. 831-844
    • Gazeau, F.1    Levy, M.2    Wilhelm, C.3
  • 26
    • 2442683843 scopus 로고    scopus 로고
    • Magnetically modulated therapeutic systems
    • Hafeli UO. Magnetically modulated therapeutic systems. Int J Pharm. 2004;277(1-2):19-24.
    • (2004) Int J Pharm , vol.277 , Issue.1-2 , pp. 19-24
    • Hafeli, U.O.1
  • 28
    • 74149084423 scopus 로고    scopus 로고
    • Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy
    • Do DP, Pai SB, Rizvi SA, D'Souza MJ. Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. Int J Pharm. 2010;386(1-2):114-121.
    • (2010) Int J Pharm , vol.386 , Issue.1-2 , pp. 114-121
    • Do, D.P.1    Pai, S.B.2    Rizvi, S.A.3    D'Souza, M.J.4
  • 29
    • 84863863368 scopus 로고    scopus 로고
    • Update on the current state of melanoma incidence
    • Little EG, Eide MJ. Update on the current state of melanoma incidence. Dermatol Clin. 2012;30(3):355-361.
    • (2012) Dermatol Clin , vol.30 , Issue.3 , pp. 355-361
    • Little, E.G.1    Eide, M.J.2
  • 30
    • 72249122960 scopus 로고    scopus 로고
    • Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    • Ho E, Clarke JD, Dashwood RH. Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr. 2009;139(12): 2393-2396.
    • (2009) J Nutr , vol.139 , Issue.12 , pp. 2393-2396
    • Ho, E.1    Clarke, J.D.2    Dashwood, R.H.3
  • 31
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • Myzak MC, Karplus PA, Chung FL, Dashwood RH. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. 2004;64(16):5767-5774.
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 32
    • 34548539541 scopus 로고    scopus 로고
    • Pro-inflammatory cytokine inhibition in the primate using microencapsulated antisense oligomers to NF-kappaB
    • Oettinger CW, D'Souza MJ, Akhavein N, Peer GT, Taylor FB, Kinasewitz GT. Pro-inflammatory cytokine inhibition in the primate using microencapsulated antisense oligomers to NF-kappaB. J Microencapsul. 2007;24(4):337-348.
    • (2007) J Microencapsul , vol.24 , Issue.4 , pp. 337-348
    • Oettinger, C.W.1    D'Souza, M.J.2    Akhavein, N.3    Peer, G.T.4    Taylor, F.B.5    Kinasewitz, G.T.6
  • 34
    • 84864797376 scopus 로고    scopus 로고
    • The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A
    • Escribese MM, Sierra-Filardi E, Nieto C, et al. The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A. J Immunol. 2012;189(4):1946-1954.
    • (2012) J Immunol , vol.189 , Issue.4 , pp. 1946-1954
    • Escribese, M.M.1    Sierra-Filardi, E.2    Nieto, C.3
  • 35
    • 36649024121 scopus 로고    scopus 로고
    • Cellular level loading and heating of superparamagnetic iron oxide nanoparticles
    • Kalambur VS, Longmire EK, Bischof JC. Cellular level loading and heating of superparamagnetic iron oxide nanoparticles. Langmuir. 2007;23(24):12329-12336.
    • (2007) Langmuir , vol.23 , Issue.24 , pp. 12329-12336
    • Kalambur, V.S.1    Longmire, E.K.2    Bischof, J.C.3
  • 36
    • 56449091115 scopus 로고    scopus 로고
    • Formulation and evaluation of albumin microspheres and its enteric coating using a spray-dryer
    • Bejugam NK, Uddin AN, Gayakwad SG, D'Souza MJ. Formulation and evaluation of albumin microspheres and its enteric coating using a spray-dryer. J Microencapsul. 2008;25(8):577-583.
    • (2008) J Microencapsul , vol.25 , Issue.8 , pp. 577-583
    • Bejugam, N.K.1    Uddin, A.N.2    Gayakwad, S.G.3    D'Souza, M.J.4
  • 37
    • 70449558745 scopus 로고    scopus 로고
    • Formulation and in vitro characterization of spray-dried antisense oligonucleotide to NF-kappaB encapsulated albumin microspheres
    • Gayakwad SG, Bejugam NK, Akhavein N, Uddin NA, Oettinger CE, D'Souza MJ. Formulation and in vitro characterization of spray-dried antisense oligonucleotide to NF-kappaB encapsulated albumin microspheres. J Microencapsul. 2009;26(8):692-700.
    • (2009) J Microencapsul , vol.26 , Issue.8 , pp. 692-700
    • Gayakwad, S.G.1    Bejugam, N.K.2    Akhavein, N.3    Uddin, N.A.4    Oettinger, C.E.5    D'Souza, M.J.6
  • 38
    • 34147174882 scopus 로고    scopus 로고
    • In-vitro anti-microbial effect of encapsulated vancomycin on internalized Staph. aureus within endothelial cells
    • Nettey H, Haswani D, D'Souza M, Oettinger C. In-vitro anti-microbial effect of encapsulated vancomycin on internalized Staph. aureus within endothelial cells. Drug Dev Ind Pharm. 2007;33(2):133-139.
    • (2007) Drug Dev Ind Pharm , vol.33 , Issue.2 , pp. 133-139
    • Nettey, H.1    Haswani, D.2    D'Souza, M.3    Oettinger, C.4
  • 39
    • 84855850311 scopus 로고    scopus 로고
    • Impact of albumin on drug delivery-new applications on the horizon
    • Elsadek B, Kratz F. Impact of albumin on drug delivery-new applications on the horizon. J Control Release. 2012;157(1):4-28.
    • (2012) J Control Release , vol.157 , Issue.1 , pp. 4-28
    • Elsadek, B.1    Kratz, F.2
  • 40
    • 0037133126 scopus 로고    scopus 로고
    • Targeting to macrophages: Role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages
    • Ahsan F, Rivas IP, Khan MA, Torres Suarez AI. Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages. J Control Release. 2002;79(1-3):29-40.
    • (2002) J Control Release , vol.79 , Issue.1-3 , pp. 29-40
    • Ahsan, F.1    Rivas, I.P.2    Khan, M.A.3    Torres Suarez, A.I.4
  • 41
    • 3042545961 scopus 로고    scopus 로고
    • Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: Effects of molecular weight and composition of PLGA on release of rifampicin
    • Makino K, Nakajima T, Shikamura M, et al. Efficient intracellular delivery of rifampicin to alveolar macrophages using rifampicin-loaded PLGA microspheres: effects of molecular weight and composition of PLGA on release of rifampicin. Colloids Surf B Biointerfaces. 2004;36(1):35-42.
    • (2004) Colloids Surf B Biointerfaces , vol.36 , Issue.1 , pp. 35-42
    • Makino, K.1    Nakajima, T.2    Shikamura, M.3
  • 42
    • 46749119051 scopus 로고    scopus 로고
    • Role of particle size in phagocytosis of polymeric microspheres
    • Champion JA, Walker A, Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres. Pharm Res. 2008;25(8): 1815-1821.
    • (2008) Pharm Res , vol.25 , Issue.8 , pp. 1815-1821
    • Champion, J.A.1    Walker, A.2    Mitragotri, S.3
  • 43
    • 0141989515 scopus 로고    scopus 로고
    • Magnetic drug targeting-biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment
    • Alexiou C, Jurgons R, Schmid RJ, et al. Magnetic drug targeting-biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment. J Drug Target. 2003;11(3):139-149.
    • (2003) J Drug Target , vol.11 , Issue.3 , pp. 139-149
    • Alexiou, C.1    Jurgons, R.2    Schmid, R.J.3
  • 44
    • 78650044241 scopus 로고    scopus 로고
    • Magnetic nanoparticle transport within flowing blood and into surrounding tissue
    • Nacev A, Beni C, Bruno O, Shapiro B. Magnetic nanoparticle transport within flowing blood and into surrounding tissue. Nanomedicine (Lond). 2010;5(9):1459-1466.
    • (2010) Nanomedicine (Lond) , vol.5 , Issue.9 , pp. 1459-1466
    • Nacev, A.1    Beni, C.2    Bruno, O.3    Shapiro, B.4
  • 45
    • 0030781225 scopus 로고    scopus 로고
    • Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: Identification of phase I metabolites and glutathione conjugates
    • Kassahun K, Davis M, Hu P, Martin B, Baillie T. Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem Res Toxicol. 1997;10(11):1228-1233.
    • (1997) Chem Res Toxicol , vol.10 , Issue.11 , pp. 1228-1233
    • Kassahun, K.1    Davis, M.2    Hu, P.3    Martin, B.4    Baillie, T.5
  • 46
    • 33846153232 scopus 로고    scopus 로고
    • Induction of GST and NQO1in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    • Zhang Y, Munday R, Jobson HE, et al. Induction of GST and NQO1in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts. J Agric Food Chem. 2006; 54(25):9370-9376.
    • (2006) J Agric Food Chem , vol.54 , Issue.25 , pp. 9370-9376
    • Zhang, Y.1    Munday, R.2    Jobson, H.E.3
  • 47
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    • Myzak MC, Dashwood WM, Orner GA, Ho E, Dashwood RH. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J. 2006;20(3):506-508.
    • (2006) FASEB J , vol.20 , Issue.3 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3    Ho, E.4    Dashwood, R.H.5
  • 48
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
    • Pledgie-Tracy A, Sobolewski MD, Davidson NE. Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther. 2007;6(3):1013-1021.
    • (2007) Mol Cancer Ther , vol.6 , Issue.3 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 49
    • 34249708966 scopus 로고    scopus 로고
    • Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres
    • Jia WJ, Liu JG, De Zhang Y, et al. Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres. J Drug Target. 2007;15(2):140-145.
    • (2007) J Drug Target , vol.15 , Issue.2 , pp. 140-145
    • Jia, W.J.1    Liu, J.G.2    De Zhang, Y.3
  • 50
    • 84870020025 scopus 로고    scopus 로고
    • Poly(acrylic acid)-modified Fe3O4microspheres for magnetic-targeted and pH-triggered anticancer drug delivery
    • Kang XJ, Dai YL, Ma PA, et al. Poly(acrylic acid)-modified Fe3O4microspheres for magnetic-targeted and pH-triggered anticancer drug delivery. Chemistry. 18(49):15676-15682.
    • Chemistry , vol.18 , Issue.49 , pp. 15676-15682
    • Kang, X.J.1    Dai, Y.L.2    Ma, P.A.3


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