Solubility of paracetamol and polyvinylpyrrolidone in mixtures of carbon dioxide, ethanol, and acetone at elevated pressures

Journal of Chemical and Engineering Data

Volumn 58, Issue 4, 2013, Pages 1054-1061

  Varona, Salima ^a   Fernández, Jennifer ^a   Rossmann, Matthias ^a   Braeuer, Andreas ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-SOLVENTS; ELEVATED PRESSURE; MOLAR FRACTIONS; MULTI PHASE SYSTEMS; POLY VINYL PYRROLIDONE; SATURATION SOLUBILITY; SINGLE-PHASE SYSTEMS; SOLUBILITY BEHAVIOR;

ACETONE; CARBON DIOXIDE; ETHANOL; MIXTURES; MOLECULAR WEIGHT;

SOLUBILITY;

EID: 84876248723     PISSN: 00219568     EISSN: 15205134     Source Type: Journal    
DOI: 10.1021/je400062w     Document Type: Article

References (29)

1. Horter, D.; Dressman, J. B. Influence of physicochemical properties of drug in the gastrointestinal tract Adv. Drug Delivery Rev. 2012, 46 (1) 75-87
2. Mura, P.; Faucci, M. T.; Manderioli, A.; Bramanti, G.; Parrini, P. Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersions Drug Dev. Ind. Pharm. 1999, 25, 257-264
3. El-Gazayerly, O. N. Characterization and evaluation of tenoxicam coprecipitates Drug Dev. Ind. Pharm. 2000, 26, 925-930
4. Folttmann, H.; Quadir, A. Polyvinylpyrrolidone (PVP)-One of the Most Widely Used Excipients in Pharmaceuticals: An Overview Drug Delivery Technol. 2008, 8 (6) 22-27
5. Galicia-Luna, L. A.; Elizalde-Solis, O. New Apparatus for Solubility Measurements of Solids in Carbon Dioxide Ind. Eng. Chem. Res. 2011, 50 (1) 207-212
6. Park, H. J.; Kim, M.; Lee, S.; Kim, J.; Woo, J.; Park, J.; Hwang, S. Recrystallization of fluconazole using the supercritical antisolvent (SAS) process Int. J. Pharm. 2007, 328, 152-160
7. Yeo, S. D.; Kim, M. S.; Lee, J. C. Recrystallization of sulfathiazole and chlor-propamide using the supercritical fluid anti-solvent process J. Supercrit. Fluids 2003, 25, 143-154
8. Steckel, H.; Thies, J.; Müller, B. W. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide Int. J. Pharm. 1997, 152, 99-110
9. Kim, M. S.; Lee, S.; Park, J. S.; Woo, J. S.; Hwang, S. J. Micronization of cilostazol using supercritical anti-solvent (SAS) process: effect of process parameters Powder Technol. 2007, 177, 64-70
10. Kumar, S. K.; Chhabria, S. P.; Reid, R. C.; Suter, U. W. Solubility of Polystyrene in Supercritical Fluids Macromolecules 1987, 20, 2550-2557
11. Garay, I.; Pocheville, A.; Madariaga, L. Polymeric microparticles prepared by supercritical antisolvent precipitation Powder Technol. 2010, 197, 211-217
12. Rossmann, M.; Braeuer, A.; Dowy, S.; Gallinger, T. G.; Leipertz, A.; Schluecker, E. Solute solubility as criterion for the appearance of amorphous particle precipitation or crystallization in the supercritical antisolvent (SAS) process J. Supercrit. Fluids 2012, 66, 350-358
13. Costa, M. S.; Duarte, A. R. C.; Cardoso, M. M.; Duarte, C. M. M. Supercritical antisolvent precipitation of PHBV microparticles Int. J. Pharm. 2007, 328, 72-77
14. Kluge, J.; Fusaro, F.; Mazzotti, M.; Muhrer, G. Production of PLGA micro- and nanocomposites by supercritical fluid extraction of emulsions: II. Encapsulation of Ketoprofen J. Supercrit. Fluids 2009, 50, 336-343
15. Mattea, F.; Martín, á.; Matías-Gago, A.; Cocero, M. J. Supercritical antisolvent precipitation from an emulsion: β-Carotene nanoparticle formation J. Supercrit. Fluids 2009, 51 (2) 238-247
16. Gokhale, A.; Khusid, B.; Dave, R. N.; Pfeffer, R. Effect of solvent strength and operating pressure on the formation of submicrometer polymer particles in supercritical microjets J. Supercrit. Fluids 2007, 43 (2) 341-356
17. Chang, S.-C.; Lee, M.-J.; Lin, H.-M. Role of phase behavior in micronization of lysozyme via a supercritical anti-solvent process Chem. Eng. J. 2008, 139, 416-425
18. Braeuer, A.; Dowy, S.; Torino, E.; Rossmann, M.; Luther, S. K.; Schluecker, E.; Leipertz, A.; Reverchon, E. Analysis of the supercritical antisolvent mechanisms governing particles precipitation and morphology by in situ laser scattering techniques Chem. Eng. J. 2001, 173, 258-266
19. Dowy, S.; Braeuer, A.; Reinhold-López, K.; Leipertz, A. Laser analyses of mixture formation and the influence of solute on particle precipitation in the SAS process J. Supercrit. Fluids 2009, 50, 265-275
20. Braeuer, A.; Dowy, S.; Torino, E.; Rossmann, M.; Luther, S. K.; Schluecker, E.; Leipertz, A.; Reverchon, E. Analysis of the supercritical antisolvent mechanisms governing particles precipitation and morphology by in situ laser scattering techniques Chem. Eng. J. 2011, 173, 258-266
21. Dowy, S.; Torino, E.; Luther, S. K.; Rossmann, M.; Braeuer, A. Imaging the Supersaturation in High-Pressure Systems for Particle Generation Chem. Eng. J. 2011, 168, 896-902
22. Sabet, J. K.; Ghotbi, C.; Dorkoosh, F.; Striolo, A. Solubilities of acetaminophen in supercritical carbon dioxide with and without menthol cosolvent: Measurement and correlation Sci. Iran. 2012, 19 (3) 619-625
23. Wubbolts, F. E.; Bruinsma, O. S. L.; van Rosmalen, G. M. Measurement and modelling of the solubility of solids in mixtures of common solvents and compressed gases J. Supercrit. Fluids 2004, 32, 79-87
24. Muntó, M.; Ventosa, N.; Sala, S.; Veciana, J. Solubility behaviors of ibuprofen and naproxen drugs in liquid "CO2-oraganic solvent" mixtures J. Supercrit. Fluids 2008, 47, 147-153
25. Pérez, Y.; Wubbolts, F. E.; Witkamp, G. J.; Jansens, P. J. Improved PCA Process for the Production of Nano- and Microparticles of polymers AIChE J. 2004, 50, 2408-2416
26. Span, R.; Wanger, W. Equations of State for Technical Applications. I. Simultaneously Optimized Functional Forms for Nonpolar and Polar Fluids Int. J. Thermophys. 2003, 24 (1) 1-39
27. Malavolta, L.; Oliveira, E.; Cilli, E. M.; Nakaie, C. R. Solvation of polymers as model for solvent effect investigation: proposition of a novel polarity scale Tetrahedron 2002, 58 (22) 4383-4394
28. Granberg, R. A.; Rasmuson, A. C. Solubility of Paracetamol in Pure Solvents J. Chem. Eng. Data 1999, 44, 1391-1395
29. Reverchon, E.; Torino, E.; Dowy, S.; Braeuer, A.; Leipertz, A. Interactions of jet fluid dynamics, phase equilibria and mass transfer during supercritical antisolvent micronization Chem. Eng. J. 2010, 156, 446-458