UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: Towards an in-depth study for its sedative-hypnotic activity

Journal of Mass Spectrometry

Volumn 48, Issue 4, 2013, Pages 448-458

  Wei, Binbin ^a   Li, Qing ^a   Fan, Ronghua ^a   Su, Dan ^b,c   Ou, Xiuli ^a   Chen, Kelin ^a   Chen, Xiaohui ^a   Jia, Ying ^a   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine   (China)

^c Jiangxi University of Chinese Traditional Medicine   (China)

Author keywords

brain microdialysate; brain tissue homogenate; Schisandra chinensis (Turcz.) Baill; sedative and hypnotic ingredients; UFLC MS MS

Indexed keywords

BRAIN MICRODIALYSATE; BRAIN TISSUE; SCHISANDRA CHINENSIS; SEDATIVE AND HYPNOTIC INGREDIENTS; UFLC-MS/MS;

BRAIN; MASS SPECTROMETRY; PHARMACOKINETICS;

DRUG PRODUCTS;

ACETONITRILE; DEOXYSHISANDRIN; FORMIC ACID; GOMISIN; GOMISIN A; HYPNOTIC SEDATIVE AGENT; LIGNAN; SCHISANDRIN; SCHISANTHERIN A; SCHIZANDRIN C; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CEREBELLUM; CORPUS STRIATUM; DRUG ABSORPTION; DRUG DETERMINATION; DRUG DISTRIBUTION; ELUTION; HIPPOCAMPUS; HYPOTHALAMUS; LIQUID CHROMATOGRAPHY; MEDULLA OBLONGATA; MICRODIALYSIS; PREMOTOR CORTEX; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHISANDRA CHINENSIS; TANDEM MASS SPECTROMETRY; TISSUE HOMOGENATE; ULTRA FAST LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY;

ANIMALS; AREA UNDER CURVE; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; HYPNOTICS AND SEDATIVES; LIGNANS; LINEAR MODELS; MALE; MICRODIALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SCHISANDRA; SENSITIVITY AND SPECIFICITY; SLEEP INITIATION AND MAINTENANCE DISORDERS; TANDEM MASS SPECTROMETRY;

RATTUS; SCHISANDRA CHINENSIS;

EID: 84876225534     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3176     Document Type: Article

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