Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture

Oncology Reports

Volumn 29, Issue 5, 2013, Pages 1714-1720

  Roomi, M Waheed ^a   Kalinovsky, Tatiana ^a   Roomi, Nusrath W ^a   Niedzwiecki, Aleksandra ^a   Rath, Matthias ^a  

^a Dr Rath Research Institute   (United States)

Author keywords

Apoptosis; MMP 2; MMP 9; Neuroblastoma; SK N MC; Tumor growth

Indexed keywords

ASCORBIC ACID; GELATINASE A; GELATINASE B; GREEN TEA EXTRACT; LYSINE; MATRIGEL; NUTRACEUTICAL; PROLINE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CELL INVASION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIET SUPPLEMENTATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; METASTASIS; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; NUTRIENT SOLUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERAPY EFFECT; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ZYMOGRAPHY;

ANIMALS; APOPTOSIS; ASCORBIC ACID; CELL LINE, TUMOR; CELL SURVIVAL; DIETARY SUPPLEMENTS; GELATINASES; HUMANS; LYSINE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, NUDE; NEUROBLASTOMA; PLANT EXTRACTS; PROLINE; RANDOM ALLOCATION; TEA; TISSUE INHIBITOR OF METALLOPROTEINASE-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84876223777     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2307     Document Type: Article

References (31)

1. American Cancer Society: Neuroblastoma: What are the key statistics about neuroblastoma? http://www.cancer.org/Cancer/Neuroblastoma/DetailedGuide/ neuroblastoma-key-statistics. Accessed Dec 6, 2012.
2. Reynolds CP and Seeger RC: Neuroblastoma. In: Cancer Treatment. Haskell CM (ed). W.B. Saunders, Philadelphia, PA, pp860-871, 1994.
3. Matthay KK, Villablanca JG, Seeger RC, Stram DO, Harris RE, Ramsay NK, Swift P, Shimada H, Black CT, Brodeur GM, Gerbing RB and Reynolds CP: Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation and 13-cis-retinoic acid. Children's Cancer Group. N Engl J Med 341: 1165-1173, 1999. (Pubitemid 29480654)
4. Roy Choudhury S, Karmakar S, Banik NL and Ray SK: Targeting angiogenesis for controlling neuroblastoma. J Oncol 2012: 782020, 2012. doi: 10.1155/2012/82020.
5. Ara T, Kusafuka T, Inoue M, Kuroda S, Fukuzawa M and Okada A: Determination of imbalance between MMP-2 and TIMP-2 in human neuroblastoma by reverse-transcription polymerase chain reaction and its correlation with tumor progression. J Pediatr Surg 35: 432-437, 2000. (Pubitemid 30131605)
6. Sugiura Y, Shimada H, Seeger RC, Laug WE and DeClerck YA: Matrix metalloproteinases-2 and-9 are expressed in human neuroblastoma: contribution of stromal cells to their production and correlation with metastasis. Cancer Res 58: 2209-2216, 1998. (Pubitemid 28232910)
7. Roomi MW, Roomi N, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: Inhibitory effect of a mixture containing ascorbic acid, lysine, proline and green tea extract on critical parameters in angiogenesis. Oncol Rep 14: 807-815, 2005.
8. Roomi MW, Roomi N, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: Inhibition of pulmonary metastasis of melanoma B16FO cells in C57BL/6 mice by a nutrient mixture consisting of ascorbic acid, lysine, proline, arginine, and green tea extract. Exp Lung Res 32: 517-530, 2006. (Pubitemid 44973608)
9. Niedzwiecki A, Roomi MW, Kalinovsky T and Rath M: Micronutrient synergy - a new tool in effective control of metastasis and other key mechanisms of cancer. Cancer Metastasis Rev 29: 529-542, 2010.
10. Ribatti D, Marimpietri D, Pastorino F, Brignole C, Nico B, Vacca A and Ponzoni M: Angiogenesis in neuroblastoma. Ann NY Acad Sci 1028: 133-142, 2004. (Pubitemid 40361817)
11. Ribatti D, Vacca A, Nico B, De Falco G, Montaldo GP and Pnzoni M: Angiogenesis and anti-angiogenesis in neuroblastoma. Eur J Cancer 38: 750-757, 2002. (Pubitemid 34280318)
12. Rath M and Pauling L: Plasmin-induced proteolysis and the role of apoprotein(a), lysine and synthetic analogs. J Orthomolecular Med 7: 17-23, 1992.
13. Sun Z, Chen YH, Wang P, Zhang J, Gurewich V, Zhang P and Liu JN: The blockage of high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochem Biophys Acta 1596: 182-192, 2002. (Pubitemid 34455046)
14. Valcic S, Timmermann BN, Alberts DS, Wachter GA, Krutzsch M, Wymer J and Guillen JM: Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. Anticancer Drugs 7: 461-468, 1996. (Pubitemid 26249199)
15. Mukhtar H and Ahmad N: Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 71 (Suppl 6): S1698-S1704, 2000.
16. Yang GY, Liao J, Kim K, Yurtow EJ and Yang CS: Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 19: 611-616, 1998. (Pubitemid 28376804)
17. Taniguchi S, Fujiki H, Kobayashi H, Go H, Miyado K, Sadano H and Shimokawa R: Effect of (-) epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. Cancer Lett 65: 51-54, 1992.
18. Hara Y: Green Tea: Health Benefits and Applications. Marcel Dekker, Inc., New York, Basel, 2001.
19. Kawakami S, Kageyama Y, Fujii Y, Kihara K and Oshima H: Inhibitory effects of N-acetyl cysteine on invasion and MMP-9 production of T24 human bladder cancer cells. Anticancer Res 21: 213-219, 2001.
20. Morini M, Cai T, Aluigi MG, Noonan DM, Masiello L, De Floro S, D'Agostinin F, Albini A and Fassima G: The role of the thiol N-acetyl cysteine in the prevention of tumor invasion and angiogenesis. Int J Biol Markers 14: 268-271, 1999. (Pubitemid 30064181)
21. Yoon SO, Kim MM and Chung AS: Inhibitory effects of selenite on invasion of HT1080 tumor cells. J Biol Chem 276: 20085-20092, 2001.
22. Carosio R, Zuccari G, Orienti I, Mangraviti S and Montaldo PG: Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake. Mol Cancer 6: 55, 2007.
23. Maramag C, Menon M, Balaji KC, Reddy PG and Laxmanan S: Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability and DNA synthesis. Prostate 32: 188-195, 1997. (Pubitemid 27337953)
24. Naidu KA, Karl RC, Naidu KA and Coppola D: Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor. Dig Dis Sci 48: 230-237, 2003. (Pubitemid 36232786)
25. Koh WS, Lee SJ, Lee H, Park C, Park MH, Kim WS, Yoon SS, Park K, Hong SI, Chung MH and Park CH: Differential effects and transport kinetics of ascorbate derivatives in leukemic cell lines. Anticancer Res 18: 2487-2493, 1998. (Pubitemid 28386538)
26. Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E and Levine M: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA 102: 13604-13609, 2005. (Pubitemid 41420895)
27. Kurbacher CM, Wagner U, Kolster B, Andreotti PE, Krebs D and Bruckner HW: Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett 103: 183-189, 1996. (Pubitemid 26147697)
28. Anthony HM and Schorah CJ: Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance. Br J Cancer 46: 354-367, 1982. (Pubitemid 12029882)
29. Nunez C, Ortiz de Apodaca Y and Ruiz A: Ascorbic acid in the plasma and blood cells of women with breast cancer. The effect of consumption of food with an elevated content of this vitamin. Nutr Hosp 10: 368-372, 1995 (In Spanish).
30. Cooke JP and Dzau VJ: Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48: 489-509, 1997. (Pubitemid 27101848)
31. Roomi MW, Ivanov V, Netke SP, Niedzwiecki A and Rath M: Serum markers of the liver, heart, and kidney and lipid profile and histopathology in ODS rats treated with nutrient synergy. J Am Coll Nutr 22: 477, 2003.