Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 5, 2013, Pages 2272-2280

  Richie, Daryl L ^a   Thompson, Katherine V ^a   Studer, Christian ^b   Prindle, Vivian C ^a   Aust, Thomas ^b   Riedl, Ralph ^b   Estoppey, David ^b   Tao, Jianshi ^a   Sexton, Jessica A ^a   Zabawa, Thomas ^a   Drumm, Joseph ^a   Cotesta, Simona ^b   Eichenberger, Jürg ^b   Schuierer, Sven ^b   Hartmann, Nicole ^b   Movva, N Rao ^b   Tallarico, John A ^a   Ryder, Neil S ^a   Hoepfner, Dominic ^b  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOLACTATE SYNTHASE INHIBITOR; AMINO ACID; ANTIFUNGAL AGENT; PUROMYCIN; PZ 0005; SULFONAMIDE; TRIAZOLOPYRIMIDINE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CRYSTAL STRUCTURE; DRUG SCREENING; GENE MUTATION; GENOME ANALYSIS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ACETOLACTATE SYNTHASE; AMINO ACIDS, BRANCHED-CHAIN; ANTIFUNGAL AGENTS; CATALYTIC DOMAIN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MUTATION; PROTEIN BINDING; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERUM; SULFONAMIDES; SULFONYLUREA COMPOUNDS;

EID: 84876220593     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01809-12     Document Type: Article

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