Divergent modulation of clinical measures of volitional and reflexive motor behaviors following serotonergic medications in human incomplete spinal cord injury

Journal of Neurotrauma

Volumn 30, Issue 6, 2013, Pages 498-502

  Thompson, Christopher K ^a,b   Hornby, T George ^a,b,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b REHABILITATION INSTITUTE OF CHICAGO   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

5 HT; SCI; spasm; spasticity; strength

Indexed keywords

CYPROHEPTADINE; ESCITALOPRAM;

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INCOMPLETE SPINAL CORD INJURY; LOCOMOTION; MALE; MOTOR PERFORMANCE; MUSCLE SPASM; MUSCLE STRENGTH; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; REFLEX; SPASTICITY; SPINAL CORD INJURY; SPINAL CORD NERVE CELL; TREATMENT RESPONSE; WALKING;

ADULT; CERVICAL VERTEBRAE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE SPASTICITY; MUSCLE STRENGTH; REFLEX; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SPINAL CORD INJURIES; THORACIC VERTEBRAE; VOLITION; WALKING;

EID: 84876218777     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2515     Document Type: Article

References (24)

1. Heckman, C.J., Lee, R.H., and Brownstone, R.M. (2003). Hyper-excitable dendrites in motoneurons and their neuromodulatory control during motor behavior. Trends Neurosci. 26, 688-695.
2. Gorassini, M.A., Knash, M.E., Harvey, P.J., Bennett, D.J., and Yang, J.F. (2004). Role of motoneurons in the generation of muscle spasms after spinal cord injury. Brain 127, 2247-2258.
3. Murray, K.C., Nakae, A., Stephens, M.J., Rank, M., D'Amico, J., Harvey, P.J., Li, X., Harris, R.L., Ballou, E.W., Anelli, R., Heckman, C.J., Mashimo, T., Vavrek, R., Sanelli, L., Gorassini, M.A., Bennett, D.J., and Fouad K. (2010). Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat. Med. 16, 694-700.
4. Bennett, D.J., Gorassini, M., Fouad K, Sanelli L, Han Y and Cheng J. (1999). Spasticity in rats with sacral spinal cord injury. J Neurotrauma 16, 69-84.
5. Stolp-Smith, K.A., and Wainberg, M.C. (1999). Antidepressant exacerbation of spasticity. Arch. Phys. Med. Rehabil. 80, 339-342.
6. Gerin, C., Becquet, D., and Privat, A. (1995). Direct evidence for the link between monoaminergic descending pathways and motor activity. I. A study with microdialysis probes implanted in the ventral funiculus of the spinal cord. Brain Res. 704, 191-201.
7. Veasey, S.C., Fornal, C.A., Metzler, C.W., and Jacobs, B.L. (1995). Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J. Neurosci. 15, 5346-5359.
8. Thomas, C.K., and del Valle, A. (2001). The role of motor unit rate modulation versus recruitment in repeated submaximal voluntary contractions performed by control and spinal cord injured subjects. J. Electromyogr. Kinesiol. 11, 217-229.
9. Hornby, T.G., Lewek, M.D., Thompson, C.K., and Heitz, R. (2009). Repeated maximal volitional effort contractions in human spinal cord injury: Initial torque increases and reduced fatigue. Neurorehabil. Neural Repair 23, 928-938.
10. Thompson, C.K., Lewek, M.D., Jayaraman, A., and Hornby, T.G. (2011). Central excitability contributes to supramaximal volitional contractions in human incomplete spinal cord injury. J. Physiol. 589, 3739-3752.
11. Barbeau, H., Richards, C.L., and Bedard, P.J. (1982). Action of cy-proheptadine in spastic paraparetic patients. J. Neurol. Neurosurg. Psychiatry 45, 923-926.
12. Thompson, C.K., Jayaraman, A., Kinnaird, C., and Hornby, T.G. (2011). Methods to quantify pharmacologically induced alterations in motor function in human incomplete sci. J. Vis. Exp. Apr 18 (50). pii: 2148. doi: 10.3791/2148.
13. Hornby, T.G., Schmit, B.D., and Theiss, R.D. (2006). Serotonergic modulation of motor function in human spinal cord injury. Program No. 146.20. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006.
14. Wainberg, M., Barbeau, H., and Gauthier, S. (1990). The effects of cyproheptadine on locomotion and on spasticity in patients with spinal cord injuries. J. Neurol. Neurosurg. Psychiatry 53, 754-763.
15. Norman, K.E., Pepin, A., and Barbeau, H. (1998). Effects of drugs on walking after spinal cord injury. Spinal Cord 36, 699-715.
16. Dam, M., Tonin, P., De Boni, A., Pizzolato, G., Casson, S., Ermani, M., Freo, U., Piron, L., and Battistin, L. (1996). Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy. Stroke 27, 1211-1214.
17. Pariente, J., Loubinoux, I., Carel, C., Albucher, J.F., Leger, A., Manelfe, C., Rascol, O., and Chollet, F. (2001). Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann. Neurol. 50, 718-729.
18. Chollet, F., Tardy, J., Albucher, J.F., Thalamas, C., Berard, E., Lamy, C., Bejot, Y., Deltour, S., Jaillard, A., Niclot, P., Guillon, B., Moulin, T., Marque, P., Pariente, J., Arnaud, C., and Loubinoux, I. (2011). Fluoxetine for motor recovery after acute ischaemic stroke (flame): A randomised placebo-controlled trial. Lancet Neurol. 10, 123-130.
19. Weeks, D.L., Greer, C.L., Bray, B.S., Schwartz, C.R., and White, J.R., Jr. (2011). Association of antidepressant medication therapy with in-patient rehabilitation outcomes for stroke, traumatic brain injury, or traumatic spinal cord injury. Arch. Phys. Med. Rehabil. 92, 683-695.
20. Kemp, B.J., and Krause, J.S. (1999). Depression and life satisfaction among people ageing with post-polio and spinal cord injury. Disabil. Rehabil. 21, 241-249.
21. Smith, B.M., Weaver, F.M., and Ullrich, P.M. (2007). Prevalence of depression diagnoses and use of antidepressant medications by veterans with spinal cord injury. Am. J. Phys. Med. Rehabil. 86, 662-671.
22. Krause, J.S., Zhai, Y., Saunders, L.L., and Carter, R.E. (2009). Risk of mortality after spinal cord injury: An 8-year prospective study. Arch. Phys. Med. Rehabil. 90, 1708-1715.
23. Kohout, R.K., Saunders, L.L., and Krause, J.S. (2011). The relationship between prescription medication use and ability to ambulate distances after spinal cord injury. Arch. Phys. Med. Rehabil. 92, 1246-1249.
24. Krause, J.S. (2010). Risk for subsequent injuries after spinal cord injury: A 10-year longitudinal analysis. Arch. Phys. Med. Rehabil. 91, 1741-1746.