Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10- anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells

Pharmazie

Volumn 68, Issue 4, 2013, Pages 293-299

  Zeng, Guang Zhi ^a   Fan, Jun Ting ^a   Xu, Jun Ju ^a   Li, Yan ^a   Tan, Ning Hua ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 1,3,6 TRIHYDROXY 9,10 ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; PLANT EXTRACT; PROTEIN BAX; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CYTOSOL; CYTOTOXICITY; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRION; RUBIA; RUBIA YUNNANENSIS; UTERINE CERVIX CANCER;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; G2 PHASE; GLUCOSIDES; HELA CELLS; HUMANS; RUBIA;

EID: 84876212580     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2013.2808     Document Type: Article

References (43)

1. Abrahamson JLA, Lee JM, Bernstein A (1995) Regulation of p53-mediated apoptosis and cell cycle arrest by steel factor. Mol Cell Biol 15: 6953-6960.
2. Aressy B,DucommunB(2008) Cell cycle control by the Cdc25 phosphatase. Anti-Cancer Agents Med Chem 8: 818-824.
3. Basu A, Haldar S (1998) The relationship between Bcl2, Bax and p53: Consequences for cell cycle progression and cell death. Mol Hum Reprod 4: 1099-1109.
4. Blankenberg FG(2009) Apoptosis imaging: Anti-cancer agents in medicinal chemistry. Anticancer Agents Med Chem 9: 944-951.
5. Bucher N, Britten CD (2008) G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer 98: 523-528.
6. Buolamwini JK (2000) Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Design 6: 379-392.
7. Chulu JLC, Liu HJ (2009) Recent patents cell cycle regulatory proteins. Recent Patents on Biotechnol 3: 1-9.
8. Chung MI, Jou SJ, Cheng TH, Lin CN,Ko FN, TengCM(1994) Antiplatelet constituents of Formosan Rubia akane. J Nat Prod 57: 313-316.
9. Collins I, Garrett MD (2005) Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr Opin Pharmacol 5: 366-373.
10. Collins K, Jacks T, Pavletich N (1997) The cell cycle and cancer. Pro Natl Acad Sci USA 94: 2776-2778.
11. Fan JT,Kuang B, Zeng GZ, Zhao SM, Ji CJ, Zhang YM, TanNH(2011) Biologically active arborinane-type triterpenoids and anthraquinones from Rubia yunnanensis. J Nat Prod 74: 2069-2080.
12. Fan JT, Su J, Peng YM, LiY, Li J, Zhou YB, Zeng GZ,YanH, TanNH(2010) Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-B activation. Bioorg Med Chem 18: 8226-8234.
13. Hermeking H, Benzinger A (2006) 14-3-3 Proteins in cell cycle regulation. Semin Cancer Biol 16: 183-192.
14. Itokawa H, Takeya K, Mori N, Hamanaka T, Sonobe T, Mihara K (1984a) Isolation and antitumor activity of cyclic hexapeptides isolated from Rubiae radix. Chem Pharm Bull 32: 284-290.
15. Itokawa H, Takeya K, Mori N, Sonobe T, Serisawa N, Hamanaka T, Mihashi S (1984b) Studies on antitumor cyclic hexapeptides RA obtained from Rubiae Radix, Rubiaceae. III. On derivatives of RA-V and their in vivo activities. Chem Pharm Bull 32: 3216-3226.
16. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95: 4997-5002.
17. Lan M (1976) Dian Nan Ben Cao, 2nd ed. Kunming, Yunnan People's Press.
18. Liu Y, Kulesz-Martin M (2001) p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequencespecific DMA binding. Carcinogenesis 22: 851-860.
19. Manion MK, Hockenbery DM (2003) Targeting Bcl-2 related proteins in cancer therapy. Cancer Biol Ther 2: S105-S114.
20. Martinou JC, Youle RJ (2011) Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 21: 92-101.
21. Maxime H, Tremblay ML, Meng TC (2007) Protein tyrosine phosphatases: Emerging regulators of apoptosis. Cell Cycle 6: 2773-2781.
22. Moon MK, Han YM, Lee YJ, Lee LH, Yang JH, Kwon BM, Kim DK (2010) Inhibitory activities of anthraquinones from Rubia akane on phosphatase regenerating liver-3. Arch Pharm Res 33: 1747-1757.
23. Narita M, Shimizu S, Ito T, Chittenden T, Luta RJ, Matsuda H, Tsujimoto Y (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA 95: 14681-14686.
24. NourNM(2009) Cervical cancer: A preventable death. Rev Obstet Gynecol 2: 240-244.
25. Ola MS, Nawaz M, Ahsan H (2011) Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 351: 41-58.
26. Pines J, Hunter T (1989) Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell 58: 833-846.
27. Schiffman M,Wentzensen N,Wacholder S, KinneyW, Gage JC, Castle PE (2011) Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst 103: 368-383.
28. Schuler M, Bossy-Wetzel E, Goldstein JC, Fitzgerald P, Green DR (2000) P53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem 275: 7337-7342.
29. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D,Warren JT, Bokesc H, Kenney S, BoydMR (1990) New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst 82: 1107-1112.
30. Smits VAJ, Medema RH (2001) Checking out the G2/M transition. Biochim Biophys Acta 1519: 1-12.
31. Soengas MS, Alarcon RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW, Lowe SW (1999) Apaf-1 and caspase 9 in p53-dependent apoptosis and tumor inhibition. Science 284: 156-159.
32. Straten P, Andersen MH (2010) The anti-apoptotic members of the Bcl-2 family are attractive tumor-associated antigens. Oncotarget 1: 239-245.
33. Tan NH, Zhou J (2006) Plant cyclopeptides. Chem Rev 106: 840-895.
34. Tao J, Morikawa T, Ando S, Matsuda H,YoshikawaM(2003) Bioactive constituents from Chinese natural medicines. XI. Inhibitors onNOproduction and degranulation in RBL-2H3 from Rubia yunnanensis: Structures of rubianosides II, III, and IV, rubianol-g, and rubianthraquinone. Chem Pharm Bull 51: 654-662.
35. Weiss RH (2003) p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer cell 4: 425-429.
36. Wohlbold L, Fisher RP (2009) Behind the wheel and under the hood: Functions of cyclin-dependent kinases in response to DNA damage. DNA Repair 8: 1018-1024.
37. Wu TS, Lin DM, Shi LS, Damu AG, Kuo PC, Kuo YH (2003) Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne. Chem Pharm Bull 51: 948-950.
38. Yang SL, Liu F (1997) Rubia: Pharmacological actions and applications. Int J Oriental Med 22: 157-160.
39. Yang Y (2000) Clinical use of Rubia yunnanensi (in Chinese). Chin J Ethnomed Ethnopharm 43: 119-120.
40. Yue GGL, Fan JT, Lee JKM, Zeng GZ, Ho TWF, Fung KP, Leung PC, Tan NH, Lau CBS (2011) Cyclopeptide RA-V inhibits angiogenesis by downregulating extracellular signal-regulated kinase 1/2 phosphorylation in HUVECand HMEC-1 endothelial cells. Br J Pharmacol 164: 1883-1898.
41. Zeng GZ, Tan NH, Ji CJ, Fan JT, Huang HQ, Han HJ, Zhou GB (2009) Apoptosis inducement of bigelovin from Inula helianthus-aquatica on human leukemia U937 cells. Phytother Res 23: 885-891.
42. Zinkel S, Gross A, Yang E (2006) Bcl-2 family in DNA damage and cell cycle control. Cell Death Differ 13: 1351-359.
43. Zivny J, Klener jr. P, Pytlik R, Andera L (2010) The role of apoptosis in cancer development and treatment: Focusing on the development and treatment of hematologic malignancies. Curr Pharm Design 16: 11-33.